Figure 4.

Displacement sensitivity and time course of step-evoked transduction currents in each zone were not strongly affected by Gpr156 deletion.

(A–F) Exemplar I_MET recordings from voltage-clamped HCs of different genotype, HC type (columns), and epithelial zone (rows). I_MET current families (averages of 3) evoked by 3 of many iterated bundle displacements (E, F), bottom: negatively and positively saturating stimuli plus the step closest to the midpoint (X_1/2) of the G(X) relation. X_max: 1.08–1.32 µm. X_min: –0.2 to –0.45 µm. Red traces, fits of current decay with Equations 2 or 3 (Methods). Holding potentials, –94 mV (type I) and –84 mV (type II). (G–H) Averaged peak (onset) G_MET(X) relations for type I (G) and type II (H) HCs. Data from 5 to 9 HCs of each type were fitted with the Boltzmann functions, which were averaged to produce mean curves shown (± SEM). X_1/2 values (filled circles) are given. I Mean maximum G_MET of type I HCs was larger in MES than in LES or striola, but there was not a significant effect of genotype. Black circles, 2 striolar type I HCs from CD1 mice.