FIGURE

Fig 9

ID

ZDB-FIG-260118-142

Publication

Flannery et al., 2026 - Impact of maternal compensation on developmental phenotypes in a zebrafish model of severe congenital muscular dystrophy

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Fig 9

Variable metabolic differences in progeny of Heterozygous and ZKO females.

A. Changes in glucose metabolism quantified via qPCR Qiagen RT² Profiler arrays show a switch between gck and hk2 expression in glucose phosphorylation in MZKO and an increase in enzymes involved in gluconeogenesis in both MHet and MZKO. B. Multiple changes in the pentose phosphate pathway are also noted mostly in MZKO. rpe which is involved in protection from oxidative stress is upregulated in both ZKO and MZKO but downregulated in MHet. C.b2m is upregulated in both MHet and MZKO. D. Model of maternal disruption affecting both MHet and MZKO at different levels. Created in BioRender. Manzini, M.C. (2026) https://BioRender.com/3rj87ca.

Expression Data

Genes:	b2m fbp2 g6pc1a.1 gck hk1 hk2 prps1b rbks rpe taldo1 tktb
Fish:	EKW pomgnt2^nj14/nj14 (EKW) pomgnt2^nj14/+ (EKW)
Anatomical Term:	whole organism
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pomgnt2^nj14/nj14 (EKW) pomgnt2^nj14/+ (EKW)
Observed In:	whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

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