FIGURE

Fig 2

ID

ZDB-FIG-260118-135

Publication

Flannery et al., 2026 - Impact of maternal compensation on developmental phenotypes in a zebrafish model of severe congenital muscular dystrophy

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Fig 2

Developmental phenotypes caused by elimination of maternal pomgnt2.

A: qPCR analysis showing high pomgnt2 mRNA expression in oocytes and increasing zygotic expression between 24 and 96 hpf. (***p < 0.001) B: Immunofluorescent staining of muscle showing that ZKOs have residual α-DG glycosylation due to maternally provided pomgnt2, but this is depleted in MZKOs without maternal pomgnt2 (10X magnification, scale bar: 100 µm). C: Survival analysis showing that MZKOs begin to deviate from the Mendelian 50/50 survival ratio between 10-14 dpf, with most MZKOs dead by 28 dpf. D: Body length measurements showing a trend toward reduction in MZKOs at 14 dpf and a significant reduction at 28 dpf (***p < 0.001).

Expression Data

Gene:	pomgnt2
Fish:	EKW
Anatomical Term:	whole organism
Stage Range:	1-cell to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pomgnt2^nj14/nj14 (EKW)
Observed In:	glycoprotein biosynthetic process whole organism
Stage Range:	Days 7-13 to Days 21-29

Phenotype Detail

Acknowledgments

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