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Flannery et al., 2026 - Impact of maternal compensation on developmental phenotypes in a zebrafish model of severe congenital muscular dystrophy

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Fig 9 Variable metabolic differences in progeny of Heterozygous and ZKO females.

A. Changes in glucose metabolism quantified via qPCR Qiagen RT² Profiler arrays show a switch between gck and hk2 expression in glucose phosphorylation in MZKO and an increase in enzymes involved in gluconeogenesis in both MHet and MZKO. B. Multiple changes in the pentose phosphate pathway are also noted mostly in MZKO. rpe which is involved in protection from oxidative stress is upregulated in both ZKO and MZKO but downregulated in MHet. C.b2m is upregulated in both MHet and MZKO. D. Model of maternal disruption affecting both MHet and MZKO at different levels. Created in BioRender. Manzini, M.C. (2026) https://BioRender.com/3rj87ca.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.