FIGURE

Fig. 8.

ID

ZDB-FIG-250422-106

Publication

Laverde et al., 2025 - Zebrafish ETS transcription factor Fli1b functions upstream of Scl/Tal1 during embryonic hematopoiesis

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Fig. 8.

A proposed model for the role of fli1b during the emergence of hematopoietic lineages. (A) fli1b is expressed in the common precursor of vascular endothelial cells and erythrocytes, the hemangioblast, where it upregulates scl expression. After the angioblast and erythroid lineages separate, fli1b is maintained only in angioblast/vascular endothelial progenitor cells, where it promotes endothelial differentiation together with etv2, whereas scl promotes the erythroid differentiation program. (B) The role of fli1b in myeloid differentiation. fli1b is required for spi1b expression in the earliest myeloid progenitors, which emerge from the anterior lateral plate mesoderm (ALPM) prior to the 15-somite stage. At approximately 24 hpf, the second wave of myeloid cells emerges from the endocardium. Endocardial-derived myelopoiesis is increased in fli1b mutants.

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Acknowledgments

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