PUBLICATION
Essential Role of Nr2f Nuclear Receptors in Patterning the Vertebrate Upper Jaw
- Authors
- Barske, L., Rataud, P., Behizad, K., Del Rio, L., Cox, S.G., Crump, J.G.
- ID
- ZDB-PUB-180124-2
- Date
- 2018
- Source
- Developmental Cell 44(3): 337-347.e5 (Journal)
- Registered Authors
- Barske, Lindsey, Crump, Gage DeKoeyer
- Keywords
- COUP-TF, Endothelin1, Nr2f1, Nr2f2, Nr2f5, bone, cartilage, jaw, nuclear receptor, pharyngeal arches
- Datasets
- GEO:GSE101719
- MeSH Terms
-
- Maxilla/embryology*
- Maxilla/physiology
- DNA-Binding Proteins/genetics
- DNA-Binding Proteins/metabolism*
- Mutation
- PubMed
- 29358039 Full text @ Dev. Cell
Abstract
The jaw is central to the extensive variety of feeding and predatory behaviors across vertebrates. The bones of the lower but not upper jaw form around an early-developing cartilage template. Whereas Endothelin1 patterns the lower jaw, the factors that specify upper-jaw morphology remain elusive. Here, we identify Nuclear Receptor 2f genes (Nr2fs) as enriched in and required for upper-jaw formation in zebrafish. Combinatorial loss of Nr2fs transforms maxillary components of the upper jaw into lower-jaw-like structures. Conversely, nr2f5 misexpression disrupts lower-jaw development. Genome-wide analyses reveal that Nr2fs repress mandibular gene expression and early chondrogenesis in maxillary precursors. Rescue of lower-jaw defects in endothelin1 mutants by reducing Nr2f dosage further demonstrates that Nr2f expression must be suppressed for normal lower-jaw development. We propose that Nr2fs shape the upper jaw by protecting maxillary progenitors from early chondrogenesis, thus preserving cells for later osteogenesis.
Genes / Markers
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping