Gene
nr2f5
- ID
- ZDB-GENE-990415-253
- Name
- nuclear receptor subfamily 2, group F, member 5
- Symbol
- nr2f5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Acts upstream of or within cranial skeletal system development and response to retinoic acid. Predicted to be located in nucleus. Is expressed in several structures, including anterior neural keel; hindbrain neural keel; mesoderm; nervous system; and pharyngeal arch.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- x70300 (34 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Okeke et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ci3000 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| el611 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | TALEN | |
| la019819Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nr2f5 | Xu et al., 2020 | |
| CRISPR2-nr2f5 | Xu et al., 2020 | |
| CRISPR3-nr2f5 | Okeke et al., 2022 | |
| CRISPR4-nr2f5 | Okeke et al., 2022 | |
| MO1-nr2f5 | N/A | (2) |
| TALEN1-nr2f5 | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR050274 | Nuclear hormone receptor family NR2 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR2 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:B3DI15 | InterPro | 403 | ||||||
| UniProtKB:Q06726 | InterPro | 403 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(UAS:nr2f5,cryaa:Cerulean) |
|
| 2 | Barske et al., 2018 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-347H1 | ZFIN Curated Data | |
| Contains | SNP | rs3728813 | Stickney et al., 2002 | |
| Contains | SNP | rs3728814 | Stickney et al., 2002 | |
| Encodes | EST | x70300 | Bertrand et al., 2007 | |
| Encodes | cDNA | MGC:194399 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194439 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131186 (1) | 3096 nt | ||
| Genomic | GenBank:BX537142 (1) | 176055 nt | ||
| Polypeptide | UniProtKB:B3DI15 (1) | 403 aa |
No data available
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Okeke, C., Paulding, D., Riedel, A., Paudel, S., Phelan, C., Teng, C.S., Barske, L. (2022) Control of cranial ectomesenchyme fate by Nr2f nuclear receptors. Development (Cambridge, England). 149(23):
- Ma, X., Zhu, P., Ding, Y., Zhang, H., Qiu, Q., Dvornikov, A.V., Wang, Z., Kim, M., Wang, Y., Lowerison, M., Yu, Y., Norton, N., Herrmann, J., Ekker, S.C., Hsiai, T.K., Lin, X., Xu, X. (2020) Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity. Science advances. 6:eaay2939
- Xu, B., Tang, X., Jin, M., Zhang, H., Du, L., Yu, S., He, J. (2020) Unifying Developmental Programs for Embryonic and Post-Embryonic Neurogenesis in the Zebrafish Retina. Development (Cambridge, England). 147(12):
- Dohn, T.E., Ravisankar, P., Tirera, F.T., Martin, K.E., Gafranek, J.T., Duong, T.B., VanDyke, T.L., Touvron, M., Barske, L.A., Crump, J.G., Waxman, J.S. (2019) Nr2f-dependent allocation of ventricular cardiomyocyte and pharyngeal muscle progenitors. PLoS Genetics. 15:e1007962
- Turner, K.J., Hoyle, J., Valdivia, L.E., Cerveny, K.L., Hart, W., Mangoli, M., Geisler, R., Rees, M., Houart, C., Poole, R.J., Wilson, S.W., Gestri, G. (2019) Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits. PLoS One. 14:e0211073
- Barske, L., Rataud, P., Behizad, K., Del Rio, L., Cox, S.G., Crump, J.G. (2018) Essential Role of Nr2f Nuclear Receptors in Patterning the Vertebrate Upper Jaw. Developmental Cell. 44(3):337-347.e5
- Duong, T.B., Ravisankar, P., Song, Y.C., Gafranek, J.T., Rydeen, A.B., Dohn, T.E., Barske, L.A., Crump, J.G., Waxman, J.S. (2017) Nr2f1a balances atrial chamber and atrioventricular canal size via BMP signaling-independent and -dependent mechanisms. Developmental Biology. 434(1):7-14
- Valdivia, L.E., Lamb, D.B., Horner, W., Wierzbicki, C., Tafessu, A., Williams, A.M., Gestri, G., Krasnow, A.M., Vleeshouwer-Neumann, T.S., Givens, M., Young, R.M., Lawrence, L.M., Stickney, H.L., Hawkins, T.A., Schwarz, Q.P., Cavodeassi, F., Wilson, S.W., Cerveny, K.L. (2016) Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish. Development (Cambridge, England). 143(7):1087-98
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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