Gene
dlx2a
- ID
- ZDB-GENE-980526-212
- Name
- distal-less homeobox 2a
- Symbol
- dlx2a Nomenclature History
- Previous Names
-
- dlx-2
- dlx2
- zgc:110518
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including neural crest cell development; pharyngeal system development; and skeletal system development. Predicted to be active in nucleus. Is expressed in several structures, including brain; cranial cartilage; neural crest; pectoral fin bud; and pharyngeal arch. Orthologous to human DLX2 (distal-less homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 443 figures from 301 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu96 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dlx2a | (2) | |
| CRISPR2-dlx2a | (2) | |
| MO1-dlx2a | N/A | (3) |
| MO2-dlx2a | N/A | (3) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Distal-less homeobox transcription factors | Distal-less-like homeobox protein, N-terminal domain | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F6NKE2 | InterPro | 274 | |||||||
| UniProtKB:P50574 | InterPro | 270 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Xia, X., Song, W., Zhang, F., Fan, Y., Zhang, B., Chen, X. (2025) ctdsp2 Knockout Induces Zebrafish Craniofacial Dysplasia via p53 Signaling Activation. International Journal of Molecular Sciences. 26:
- Chowdhury, G., Umeda, K., Ohyanagi, T., Nasu, K., Yamasu, K. (2024) Involvement of nr2f genes in brain regionalization and eye development during early zebrafish development. Development, growth & differentiation. 66(2):145-160
- Ding, S., Aziz, T., Meng, A., Jia, S. (2024) Aagab is required for zebrafish larval development by regulating neural activity. Journal of genetics and genomics = Yi chuan xue bao. 51(6):630-641
- Guo, X., Yang, L., Wang, Y., Yuan, M., Zhang, W., He, X., Wang, Q. (2024) Wnt2bb signaling promotes pharyngeal chondrogenic precursor proliferation and chondrocyte maturation by activating Yap expression in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. :
- Lawir, D.F., Soza-Ried, C., Iwanami, N., Siamishi, I., Bylund, G.O., O Meara, C., Sikora, K., Kanzler, B., Johansson, E., Schorpp, M., Cauchy, P., Boehm, T. (2024) Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish. Communications biology. 7:3131
- Li, D., Tian, Y., Vona, B., Yu, X., Lin, J., Ma, L., Lou, S., Li, X., Zhu, G., Wang, Y., Du, M., Wang, L., Pan, Y. (2024) A TAF11 variant contributes to non-syndromic cleft lip only through modulating neural crest cell migration. Human molecular genetics. :
- Niu, X., Zhang, F., Gu, W., Zhang, B., Chen, X. (2024) FBLN2 is associated with Goldenhar syndrome and is essential for cranial neural crest cell development. Annals of the New York Academy of Sciences. 1537(1):113-128
- Raterman, S.T., Wagener, F.A.D.T.G., Zethof, J., Cuijpers, V., Klaren, P.H.M., Metz, J.R., Von den Hoff, J.W. (2024) foxe1 mutant zebrafish show indications of a hypothyroid phenotype and increased sensitivity to ethanol for craniofacial malformations. Developmental Dynamics : an official publication of the American Association of Anatomists. :
- Roychaudhury, A., Lee, Y.R., Choi, T.I., Thomas, M.G., Kahn, T.N., Yousaf, H., Skinner, C., Maconachie, G., Crosier, M., Horak, H., Constantinescu, C.S., Kim, T.Y., Lee, K.H., Kyung, J.J., Wang, T., Ku, B., Chodirker, B.N., Hammer, M.F., Gottlob, I., Norton, W.H.J., Gorlei, R., Kim, H.G., Graziano, C., Pippucci, T., Lovino, E., Montanari, F., Severi, G., Toro, C., Boerkoel, C.F., Cha, H.S., Choi, C.Y., Kim, S., Yoon, J.Y., Gilmore, K., Vora, N.L., Davis, E.E., Chudley, A.E., Schwartz, C.E., and Kim, C.H. (2024) SRPK3 Is Essential for Cognitive and Ocular Development in Humans and Zebrafish, Explaining X-Linked Intellectual Disability. Annals of neurology. 96(5):914-931
- Song, W., Xia, X., Fan, Y., Zhang, B., Chen, X. (2024) Functional and Genetic Analyses Unveil the Implication of CDC27 in Hemifacial Microsomia. International Journal of Molecular Sciences. 25(9):
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