Gene
nr2f1b
- ID
- ZDB-GENE-040426-1438
- Name
- nuclear receptor subfamily 2, group F, member 1b
- Symbol
- nr2f1b Nomenclature History
- Previous Names
-
- nr2f1l
- COUPTFalpha-B (1)
- zgc:65854
- zgc:77353
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in angioblast cell migration. Acts upstream of or within brain segmentation; camera-type eye development; and venous blood vessel development. Predicted to be located in nucleus. Is expressed in several structures, including basal plate midbrain region; midbrain neural keel; nervous system; pharyngeal arch; and vasculature. Human ortholog(s) of this gene implicated in Bosch-Boonstra-Schaaf optic atrophy syndrome. Orthologous to human NR2F1 (nuclear receptor subfamily 2 group F member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65854 (30 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nr2f1b | Buono et al., 2021 | |
| CRISPR2-nr2f1b | Buono et al., 2021 | |
| CRISPR3-nr2f1b | Chowdhury et al., 2024 | |
| MO1-nr2f1b | N/A | Samarut et al., 2014 |
| MO2-nr2f1b | N/A | (2) |
| MO3-nr2f1b | N/A | (2) |
| MO4-nr2f1b | N/A | (3) |
| TALEN1-nr2f1b | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bosch-Boonstra-Schaaf optic atrophy syndrome | Alliance | Bosch-Boonstra-Schaaf optic atrophy syndrome | 615722 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR050274 | Nuclear hormone receptor family NR2 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR2 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QGF2 | InterPro | 388 | ||||||
| UniProtKB:Q6PH18 | InterPro | 389 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nr2f1b-201
(1)
|
Ensembl | 2,786 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-33D3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65854 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:77353 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200592 (1) | 2792 nt | ||
| Genomic | GenBank:CT583727 (1) | 165752 nt | ||
| Polypeptide | UniProtKB:Q6PH18 (1) | 389 aa |
- Chowdhury, G., Umeda, K., Ohyanagi, T., Nasu, K., Yamasu, K. (2024) Involvement of nr2f genes in brain regionalization and eye development during early zebrafish development. Development, growth & differentiation. 66(2):145-160
- England, S.J., Campbell, P.C., Banerjee, S., Bates, R.L., Grieb, G., Fancher, W.F., Lewis, K.E. (2024) Transcriptional regulators with broad expression in the zebrafish spinal cord. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(11):1036-1055
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Wang, Y.S., Chen, Y.T., Wu, C.Y. (2023) Functional characterization of stap2b in zebrafish vascular development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e23053e23053
- Li, R.F., Wang, Y.S., Lu, F.I., Huang, Y.S., Chiu, C.C., Tai, M.H., Wu, C.Y. (2022) Identification of Novel Vascular Genes Downstream of Islet2 and Nr2f1b Transcription Factors. Biomedicines. 10(6)
- Okeke, C., Paulding, D., Riedel, A., Paudel, S., Phelan, C., Teng, C.S., Barske, L. (2022) Control of cranial ectomesenchyme fate by Nr2f nuclear receptors. Development (Cambridge, England). 149(23):
- Wang, Y.S., Huang, Y.S., Chiu, C.C., Wu, T.Y., Zhou, J.Q., Liang, S.R., Tai, M.H., Wu, C.Y. (2022) Interaction of transcription factors Islet2 and Nr2f1b to control vascular patterning during zebrafish development. Biochemical and Biophysical Research Communications. 604:123-129
- Buono, L., Corbacho, J., Naranjo, S., Almuedo-Castillo, M., Moreno-Marmol, T., de la Cerda, B., Sanbria-Reinoso, E., Polvillo, R., Díaz-Corrales, F.J., Bogdanovic, O., Bovolenta, P., Martínez-Morales, J.R. (2021) Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish. Nature communications. 12:3866
- Mitchell, J.M., Sucharov, J., Pulvino, A.T., Brooks, E.P., Gillen, A.E., Nichols, J.T. (2021) The alx3 gene shapes the zebrafish neurocranium by regulating frontonasal neural crest cell differentiation timing. Development (Cambridge, England). 148(7):
- Espino-Saldaña, A.E., Durán-Ríos, K., Olivares-Hernandez, E., Rodríguez-Ortiz, R., Arellano-Carbajal, F., Martínez-Torres, A. (2020) Temporal and spatial expression of zebrafish mctp genes and evaluation of frameshift alleles of mctp2b. Gene. 738:144371
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