Gene
nr2f1a
- ID
- ZDB-GENE-980526-115
- Name
- nuclear receptor subfamily 2, group F, member 1a
- Symbol
- nr2f1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Acts upstream of or within several processes, including brain segmentation; circulatory system development; and endothelial cell proliferation. Predicted to be located in nucleus. Is expressed in several structures, including basal plate midbrain region; brain; cardiovascular system; head; and mesoderm. Human ortholog(s) of this gene implicated in Bosch-Boonstra-Schaaf optic atrophy syndrome. Orthologous to human NR2F1 (nuclear receptor subfamily 2 group F member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 29 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:76864 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ci1009 | Allele with one deletion | Exon 2 | Premature Stop | CRISPR | |
| ci1017 | Allele with one delins | 5' UTR | Unknown | ENU | |
| el512 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | TALEN | |
| sa11358 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14691 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20527 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40551 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45227 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sud21 | Allele with one deletion | Exon 1 | Unknown | CRISPR |
1 - 9 of 9
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nr2f1a | (3) | |
| CRISPR2-nr2f1a | Buono et al., 2021 | |
| CRISPR3-nr2f1a | Buono et al., 2021 | |
| CRISPR4-nr2f1a | Chowdhury et al., 2024 | |
| MO1-nr2f1a | N/A | Samarut et al., 2014 |
| MO2-nr2f1a | N/A | Wu et al., 2014 |
| MO3-nr2f1a | N/A | Wu et al., 2014 |
| TALEN1-nr2f1a | (4) |
1 - 8 of 8
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bosch-Boonstra-Schaaf optic atrophy syndrome | Alliance | Bosch-Boonstra-Schaaf optic atrophy syndrome | 615722 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR050274 | Nuclear hormone receptor family NR2 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR2 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q06725 | InterPro | 411 | ||||||
| UniProtKB:A0A8M9Q2V3 | InterPro | 235 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nr2f1a-201
(1)
|
Ensembl | 2,994 nt |
1 - 1 of 1
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-nr2f1a | polyclonal | Rabbit |
|
1 |
1 - 1 of 1
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-10A3 | ZFIN Curated Data | |
| Encodes | EST | fc10d05 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65769 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76864 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131180 (1) | 2937 nt | ||
| Genomic | GenBank:CR751602 (2) | 65729 nt | ||
| Polypeptide | UniProtKB:Q06725 (1) | 411 aa |
- Chowdhury, G., Umeda, K., Ohyanagi, T., Nasu, K., Yamasu, K. (2024) Involvement of nr2f genes in brain regionalization and eye development during early zebrafish development. Development, growth & differentiation. 66(2):145-160
- Coppola, U., Saha, B., Kenney, J., Waxman, J.S. (2024) A Foxf1-Wnt-Nr2f1 cascade promotes atrial cardiomyocyte differentiation in zebrafish. PLoS Genetics. 20:e1011222e1011222
- Umeda, K., Tanaka, K., Chowdhury, G., Nasu, K., Kuroyanagi, Y., Yamasu, K. (2024) Evolutionarily conserved roles of foxg1a in the developing subpallium of zebrafish embryos. Development, growth & differentiation. 66(3):219-234
- Gafranek, J.T., D'Aniello, E., Ravisankar, P., Thakkar, K., Vagnozzi, R.J., Lim, H.W., Salomonis, N., Waxman, J.S. (2023) Sinus venosus adaptation models prolonged cardiovascular disease and reveals insights into evolutionary transitions of the vertebrate heart. Nature communications. 14:55095509
- Martin, K.E., Ravisankar, P., Beerens, M., MacRae, C.A., Waxman, J.S. (2023) Nr2f1a maintains atrial nkx2.5 expression to repress pacemaker identity within venous atrial cardiomyocytes of zebrafish. eLIFE. 12:
- Okeke, C., Paulding, D., Riedel, A., Paudel, S., Phelan, C., Teng, C.S., Barske, L. (2022) Control of cranial ectomesenchyme fate by Nr2f nuclear receptors. Development (Cambridge, England). 149(23):
- Song, M., Yuan, X., Racioppi, C., Leslie, M., Stutt, N., Aleksandrova, A., Christiaen, L., Wilson, M.D., Scott, I.C. (2022) GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate. Science advances. 8:eabg0834
- Buono, L., Corbacho, J., Naranjo, S., Almuedo-Castillo, M., Moreno-Marmol, T., de la Cerda, B., Sanbria-Reinoso, E., Polvillo, R., Díaz-Corrales, F.J., Bogdanovic, O., Bovolenta, P., Martínez-Morales, J.R. (2021) Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish. Nature communications. 12:3866
- Casey, M.A., Hill, J.T., Hoshijima, K., Bryan, C.D., Gribble, S.L., Brown, J.T., Chien, C.B., Yost, H.J., Kwan, K.M. (2021) Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. G3 (Bethesda). 12(3):
- den Broeder, M.J., Ballangby, J., Kamminga, L.M., Aleström, P., Legler, J., Lindeman, L.C., Kamstra, J.H. (2020) Inhibition of methyltransferase activity of enhancer of zeste 2 leads to enhanced lipid accumulation and altered chromatin status in zebrafish. Epigenetics & chromatin. 13:5
1 - 10 of 41
Show