Gene
sox10
- ID
- ZDB-GENE-011207-1
- Name
- SRY-box transcription factor 10
- Symbol
- sox10 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in olfactory bulb development. Acts upstream of or within with a positive effect on iridophore differentiation; melanocyte differentiation; and xanthophore differentiation. Acts upstream of or within several processes, including glial cell differentiation; inner ear development; and mesenchymal cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including embryonic structure; glioblast; head; nervous system; and neural crest. Used to study Hirschsprung's disease and Waardenburg syndrome. Human ortholog(s) of this gene implicated in Kallmann syndrome; PCWH syndrome; Waardenburg syndrome type 2E; and Waardenburg syndrome type 4C. Orthologous to human SOX10 (SRY-box transcription factor 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 289 figures from 191 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 81 figures from 36 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| baz1 | Allele with one point mutation | Unknown | Missense | ENU | |
| ci3020 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| m241 | unknown | Unknown | Unknown | ENU | |
| m618 | Allele with one point mutation | Unknown | Missense | ENU | |
| sox10_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| t3 | Allele with one insertion | Unknown | Unknown | ENU | |
| tw2 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tw11 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| utr13e1 | unknown | Unknown | Unknown | not specified | |
| zf3259Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| PCWH syndrome | Alliance | PCWH syndrome | 609136 |
| Waardenburg syndrome type 2E | Alliance | Waardenburg syndrome, type 2E, with or without neurologic involvement | 611584 |
| Waardenburg syndrome type 4C | Alliance | Waardenburg syndrome, type 4C | 613266 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Waardenburg syndrome | sox10t3/t3 | standard conditions | Dutton et al., 2001 |
| Waardenburg syndrome | sox10m618/m618 (AB) | standard conditions | Dutton et al., 2001 |
| Hirschsprung's disease | sox10t3/t3 | control | Rolig et al., 2017 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | High mobility group box domain | High mobility group box domain superfamily | Sox developmental protein N-terminal | SOX Transcription Factors |
|---|---|---|---|---|---|---|
| UniProtKB:Q90XD1 | InterPro | 485 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-4.7sox10:GFP) |
|
| 3 | (21) | |
| Tg(-4.9sox10:EGFP) |
|
| 1 | (149) | |
| Tg(-7.2sox10:EGFP) |
|
| 1 | (32) | |
| Tg(sox10:mRFP) |
|
| 2 | (135) | |
| Tg(-1.25sox10:GFP) |
|
| 1 | (5) | |
| Tg1(sox10:mCherry-CAAX) |
|
| 1 | Zebrafish Nomenclature Committee | |
| Tg2(sox10:EGFP) |
|
| 1 | Cunningham et al., 2021 | |
| Tg2(sox10:GAL4-VP16) |
|
| 1 | (3) | |
| Tg2(sox10:Hsa.PDGFRA) |
|
| 1 | Ki et al., 2017 | |
| Tg2(sox10:Kaede) |
|
| 1 | Okada et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-201F15 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:100757 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195295 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195310 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131875 (1) | 3231 nt | ||
| Genomic | GenBank:CR394546 (1) | 174132 nt | ||
| Polypeptide | UniProtKB:Q90XD1 (1) | 485 aa |
- Gjorcheska, S., Paudel, S., McLeod, S., Paulding, D., Snape, L., Sosa, K.C., Duan, C., Kelsh, R., Barske, L. (2025) Sox10 is required for systemic initiation of bone mineralization. Development (Cambridge, England). 152(2):
- Korzeniwsky, K.G., de Mello, P.L.H., Liang, Y., Feltes, M., Farber, S.A., Parichy, D.M. (2025) Dominant Negative Mitf Allele Impacts Melanophore and Xanthophore Development and Reveals Collaborative Interactions With Tfec in Zebrafish Chromatophore Lineages. Pigment cell & melanoma research. 38:e70009e70009
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Ahuja, S., Adjekukor, C., Li, Q., Kocha, K.M., Rosin, N., Labit, E., Sinha, S., Narang, A., Long, Q., Biernaskie, J., Huang, P., Childs, S.J. (2024) The development of brain pericytes requires expression of the transcription factor nkx3.1 in intermediate precursors. PLoS Biology. 22:e3002590e3002590
- Bailon-Zambrano, R., Keating, M.K., Sales, E.C., Nichols, A.R., Gustafson, G.E., Hopkins, C.A., Kocha, K.M., Huang, P., Barske, L., Nichols, J.T. (2024) The sclerotome is the source of the dorsal and anal fin skeleton and its expansion is required for median fin development. Development (Cambridge, England). 151(24):
- Bromley-Coolidge, S., Iruegas, D., Appel, B. (2024) Cspg4 sculpts oligodendrocyte precursor cell morphology. Differentiation; research in biological diversity. 140:100819100819
- Caetano da Silva, C., Macias Trevino, C., Mitchell, J., Murali, H., Tsimbal, C., Dalessandro, E., Carroll, S.H., Kochhar, S., Curtis, S.W., Cheng, C.H.E., Wang, F., Kutschera, E., Carstens, R.P., Xing, Y., Wang, K., Leslie, E.J., Liao, E.C. (2024) Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis. Communications biology. 7:10401040
- Cero, C., House, J.S., Verdi, V., Ferguson, J.L., Jima, D.D., Selmek, A.A., Patania, O.M., Dwyer, J.E., Wei, B.R., Lloyd, D.T., Shive, H.R. (2024) Profiling the cancer-prone microenvironment in a zebrafish model for MPNST. Oncogene. 44(3):179-191
- Chen, Y.C., Martins, T.A., Marchica, V., Panula, P. (2024) Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. Frontiers in Cellular Neuroscience. 17:12897941289794
- Desingu Rajan, A.R., Huang, Y., Stundl, J., Chu, K., Irodi, A., Yang, Z., Applegate, B.E., Bronner, M.E. (2024) Generation of a zebrafish neurofibromatosis model via inducible knockout of nf2. Disease models & mechanisms. 17(12):
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