Gene
nr2f2
- ID
- ZDB-GENE-990415-252
- Name
- nuclear receptor subfamily 2, group F, member 2
- Symbol
- nr2f2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Acts upstream of with a positive effect on venous endothelial cell fate commitment. Acts upstream of or within brain segmentation and circulatory system development. Predicted to be located in nucleus. Is expressed in several structures, including brain; head; hindbrain neural keel; midbrain neural tube; and neural crest cell. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5. Orthologous to human NR2F2 (nuclear receptor subfamily 2 group F member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- s80986 (32 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ci3005 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| el506 | Allele with one deletion | Exon 1 | Premature Stop | TALEN | |
| hu10330 | Allele with one insertion | Unknown | Frameshift, Premature Stop | TALEN | |
| la020341Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027933Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa18083 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sud23 | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nr2f2 | Okeke et al., 2022 | |
| CRISPR2-nr2f2 | Okeke et al., 2022 | |
| CRISPR3-nr2f2 | Chowdhury et al., 2024 | |
| MO1-nr2f2 | N/A | (4) |
| MO2-nr2f2 | N/A | (2) |
| MO3-nr2f2 | N/A | Swift et al., 2014 |
| MO4-nr2f2 | N/A | Seifinejad et al., 2019 |
| MO5-nr2f2 | N/A | Wang et al., 2022 |
| MO6-nr2f2 | N/A | Wang et al., 2022 |
| TALEN1-nr2f2 | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| 46,XX sex reversal 5 | Alliance | 46XX sex reversal 5 | 618901 |
| Congenital heart defects, multiple types, 4 | 615779 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR050274 | Nuclear hormone receptor family NR2 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR2 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q91430 | InterPro | 422 | ||||||
| UniProtKB:A0AB32T5U5 | InterPro | 428 | ||||||
| UniProtKB:A0AB32T6C1 | InterPro | 280 |
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Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-208H1 | ZFIN Curated Data | |
| Contained in | BAC | CH211-247G11 | ZFIN Curated Data | |
| Encodes | EST | fc94g08 | ZFIN Curated Data | |
| Encodes | EST | s80986 | (2) | |
| Encodes | EST | wz4759 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193590 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131183 (1) | 4272 nt | ||
| Genomic | GenBank:BX569787 (2) | 214158 nt | ||
| Polypeptide | UniProtKB:A0AB32T5U5 (1) | 428 aa |
- Chowdhury, G., Umeda, K., Ohyanagi, T., Nasu, K., Yamasu, K. (2024) Involvement of nr2f genes in brain regionalization and eye development during early zebrafish development. Development, growth & differentiation. 66(2):145-160
- Gafranek, J.T., D'Aniello, E., Ravisankar, P., Thakkar, K., Vagnozzi, R.J., Lim, H.W., Salomonis, N., Waxman, J.S. (2023) Sinus venosus adaptation models prolonged cardiovascular disease and reveals insights into evolutionary transitions of the vertebrate heart. Nature communications. 14:55095509
- Okeke, C., Paulding, D., Riedel, A., Paudel, S., Phelan, C., Teng, C.S., Barske, L. (2022) Control of cranial ectomesenchyme fate by Nr2f nuclear receptors. Development (Cambridge, England). 149(23):
- Owen, N., Toms, M., Young, R.M., Eintracht, J., Sarkar, H., Brooks, B.P., Moosajee, M., Genomics England Research Consortium (2022) Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis. Genetics in medicine : official journal of the American College of Medical Genetics. 24(5):1073-1084
- Wang, Y.S., Huang, Y.S., Chiu, C.C., Wu, T.Y., Zhou, J.Q., Liang, S.R., Tai, M.H., Wu, C.Y. (2022) Interaction of transcription factors Islet2 and Nr2f1b to control vascular patterning during zebrafish development. Biochemical and Biophysical Research Communications. 604:123-129
- Hoffmann, S., Schmitteckert, S., Raedecke, K., Rheinert, D., Diebold, S., Roeth, R., Weiss, B., Granzow, M., Niesler, B., Griesbeck, A., Eckstein, V., Zimmermann, W.H., Just, S., Rappold, G.A. (2021) Network-driven discovery yields new insight into Shox2-dependent cardiac rhythm control. Biochimica et biophysica acta. Gene regulatory mechanisms. 1864(4-5):194702
- Jerafi-Vider, A., Bassi, I., Moshe, N., Tevet, Y., Hen, G., Splittstoesser, D., Shin, M., Lawson, N.D., Yaniv, K. (2021) VEGFC/FLT4-induced cell-cycle arrest mediates sprouting and differentiation of venous and lymphatic endothelial cells. Cell Reports. 35:109255
- Espino-Saldaña, A.E., Durán-Ríos, K., Olivares-Hernandez, E., Rodríguez-Ortiz, R., Arellano-Carbajal, F., Martínez-Torres, A. (2020) Temporal and spatial expression of zebrafish mctp genes and evaluation of frameshift alleles of mctp2b. Gene. 738:144371
- Lawson, N.D., Li, R., Shin, M., Grosse, A., Yukselen, O., Stone, O.A., Kucukural, A., Zhu, L. (2020) An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes. eLIFE. 9:
- Dohn, T.E., Ravisankar, P., Tirera, F.T., Martin, K.E., Gafranek, J.T., Duong, T.B., VanDyke, T.L., Touvron, M., Barske, L.A., Crump, J.G., Waxman, J.S. (2019) Nr2f-dependent allocation of ventricular cardiomyocyte and pharyngeal muscle progenitors. PLoS Genetics. 15:e1007962
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