FIGURE

Fig. 1

ID

ZDB-FIG-210318-13

Publication

Inderbinen et al., 2020 - Species-specific differences in the inhibition of 11β-hydroxysteroid dehydrogenase 2 by itraconazole and posaconazole

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Fig. 1

Inhibition of human, mouse, rat and zebrafish 11β-HSD2 activity. Lysates of HEK-293 cells expressing recombinant 11β-HSD2 of the respective species were incubated for 10 min (human) or 20 min (mouse, rat, zebrafish) in the presence of 50 nM cortisol, 500 μM NAD⁺ and increasing concentrations of posaconazole (A), itraconazole (B) or OHI (C). Substrate conversion was normalized to that of the vehicle control (DMSO; 0.3% for posaconazole, 0.6% for itraconazole and 1.2% for OHI). Inhibition curves were fitted and analyzed by non-linear regression. Data shown are from at least three independent experiments and represent mean ± SD.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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