FIGURE

Fig. 4

ID

ZDB-FIG-210318-16

Publication

Inderbinen et al., 2020 - Species-specific differences in the inhibition of 11β-hydroxysteroid dehydrogenase 2 by itraconazole and posaconazole

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Fig. 4

Effect of the substitution of the C-terminal region of human and mouse 11β-HSD2 on azole fungicide-mediated inhibition. Lysates of HEK-293 cells expressing the indicated 11β-HSD2 construct were incubated for 10 min (human, chimera B) or 20 min (mouse, chimera A) with 50 nM cortisol, 500 μM NAD+ and 1 μM or 10 μM of test substances. Substrate conversion was normalized to vehicle control (0.4% DMSO). Data from three independent experiments represent mean ± SD. Two-way ANOVA with Bonferroni's post hoc test, p values: * < 0.05, **** < 0.0001 and ns (not significant), n.d. (not detected).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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