Gene

cxcr4b

ID
ZDB-GENE-010614-1
Name
chemokine (C-X-C motif), receptor 4b
Symbol
cxcr4b Nomenclature History
Previous Names
  • drCXCR4b1 (1)
  • cb403 (1)
  • ody
  • odysseus
  • zgc:109863
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Enables G protein-coupled chemoattractant receptor activity. Involved in Kupffer's vesicle development and localization of cell. Acts upstream of or within several processes, including nervous system development; posterior lateral line neuromast primordium migration; and regulation of chemotaxis. Located in plasma membrane. Is expressed in several structures, including anterior neural keel; immature eye; mesoderm; nervous system; and neurogenic placode. Human ortholog(s) of this gene implicated in several diseases, including WHIM syndrome 1; bone disease (multiple); hematologic cancer (multiple); pancreatic adenocarcinoma; and prostate cancer. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
117 figures from 85 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
25 figures from 18 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ioz106Allele with one deletionUnknownUnknownCRISPR
szy206Allele with one deletionExon 2Unknownnot specified
t26035Allele with one point mutationUnknownPremature Stopnot specified
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Sequence Targeting Reagents
Human Disease
Associated With cxcr4b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
WHIM syndrome 1 Alliance Myelokathexis, isolated 193670
WHIM syndrome 1 Alliance WHIM syndrome 1 193670
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Associated With cxcr4b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000355 Chemokine receptor family
Family IPR001277 CXC chemokine receptor 4/atypical chemokine receptor 2
Family IPR050119 C-C chemokine receptor type 1-9-like
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Domain Details Per Protein
Protein Additional Resources Length C-C chemokine receptor type 1-9-like Chemokine receptor family CXC chemokine receptor 4/atypical chemokine receptor 2 GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:Q9PTF7 InterPro 353
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 9
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cxcr4b-201 (1) Ensembl 1,674 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cxcr4b monoclonal Mouse
2
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Plasmids
Constructs
1 - 10 of 41
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inFosmidCH1073-406F3ZFIN Curated Data
EncodesESTcb403Thisse et al., 2001
EncodescDNAMGC:109863ZFIN Curated Data
EncodescDNAMGC:192953ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanCXCR42
Amino acid sequence comparison (3)
Conserved genome location (synteny) (1)
MouseCxcr41
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
Coincident expression (1)
Citations
1 - 10 of 221
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