Gene
cxcr4b
- ID
- ZDB-GENE-010614-1
- Name
- chemokine (C-X-C motif), receptor 4b
- Symbol
- cxcr4b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables G protein-coupled chemoattractant receptor activity. Involved in Kupffer's vesicle development and localization of cell. Acts upstream of or within several processes, including nervous system development; posterior lateral line neuromast primordium migration; and regulation of chemotaxis. Located in plasma membrane. Is expressed in several structures, including anterior neural keel; immature eye; mesoderm; nervous system; and neurogenic placode. Human ortholog(s) of this gene implicated in several diseases, including WHIM syndrome 1; bone disease (multiple); hematologic cancer (multiple); pancreatic adenocarcinoma; and prostate cancer. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 117 figures from 85 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb403 (56 images)
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 18 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| WHIM syndrome 1 | Alliance | Myelokathexis, isolated | 193670 |
| WHIM syndrome 1 | Alliance | WHIM syndrome 1 | 193670 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR017452 | GPCR, rhodopsin-like, 7TM |
| Family | IPR000276 | G protein-coupled receptor, rhodopsin-like |
| Family | IPR000355 | Chemokine receptor family |
| Family | IPR001277 | CXC chemokine receptor 4/atypical chemokine receptor 2 |
| Family | IPR050119 | C-C chemokine receptor type 1-9-like |
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Domain Details Per Protein
| Protein | Additional Resources | Length | C-C chemokine receptor type 1-9-like | Chemokine receptor family | CXC chemokine receptor 4/atypical chemokine receptor 2 | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q9PTF7 | InterPro | 353 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cxcr4b-201
(1)
|
Ensembl | 1,674 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cxcr4b | monoclonal | Mouse |
|
2 |
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Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1(-8mpx:cxcr4b-EGFP) |
|
| 1 | (10) | |
| Tg(-8.4neurog1:cxcr4b-mCherry) |
|
| 1 | Aguillon et al., 2020 | |
| Tg(-8mpx:cxcr4b-EGFP) |
|
| 1 | (2) | |
| TgBAC2(cxcr4b:LEXPR,LEXOP:C3-2A-h2az2a-Cerulean) |
|
| 1 | Qian et al., 2023 | |
| TgBAC(cxcr4b:Cerulean-CAAX) |
|
| 1 | Lau et al., 2020 | |
| TgBAC(cxcr4b:cxcr4a) |
|
| 1 | Colak-Champollion et al., 2019 | |
| TgBAC(cxcr4b:cxcr4b-Citrine) |
|
|
| 1 | Lau et al., 2020 |
| TgBAC(cxcr4b:cxcr4b-EGFP-IRES-mKate2-CAAX,cryaa:DsRed) |
|
| 2 | (6) | |
| TgBAC(cxcr4b:cxcr4b-GFP) |
|
|
| 1 | (5) |
| TgBAC(cxcr4b:cxcr4b_I7E_I8E-mKate2-IRES-EGFP-CAAX) |
|
| 1 | Lau et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-406F3 | ZFIN Curated Data | |
| Encodes | EST | cb403 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:109863 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192953 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131834 (1) | 1651 nt | ||
| Genomic | GenBank:CU694482 (2) | 35104 nt | ||
| Polypeptide | UniProtKB:Q9PTF7 (1) | 353 aa |
- Borges, A., Pinto-Teixeira, F., Wibowo, I., Pogoda, H.M., Hammerschmidt, M., Kawakami, K., López-Schier, H., Miranda-Rodríguez, J.R. (2024) Incoherent collective cell chemotaxis underlies organ dysmorphia in a model of branchio-oto-renal syndrome. microPublication. Biology. 2024:
- Gimenez, G., Kalev-Zylinska, M.L., Morison, I., Bohlander, S.K., Horsfield, J.A., Antony, J. (2024) Cohesin rad21 mutation dysregulates erythropoiesis and granulopoiesis output within the whole kidney marrow of adult zebrafish. American journal of physiology. Cell physiology. 328(1):C9-C19
- Leiba, J., Sipka, T., Begon-Pescia, C., Bernardello, M., Tairi, S., Bossi, L., Gonzalez, A.A., Mialhe, X., Gualda, E., Loza-Alvarez, P., Blanc-Potard, A., Lutfalla, G., Nguyen-Chi, M.E. (2024) Dynamics of macrophage polarization support Salmonella persistence in a whole living organism. eLIFE. 13:
- Park, G., Foster, C.A., Malone-Perez, M., Hasan, A., Macias, J.J., Frazer, J.K. (2024) Diverse Epithelial Lymphocytes in Zebrafish Revealed Using a Novel Scale Biopsy Method. Journal of immunology (Baltimore, Md. : 1950). 213(12):1902-1914
- Peterson, E.A., Sun, J., Chen, X., Wang, J. (2024) Neutrophils facilitate the epicardial regenerative response after zebrafish heart injury. Developmental Biology. 508:93-106
- Wright, K., Han, D.J., Song, R., de Silva, K., Plain, K.M., Purdie, A.C., Shepherd, A., Chin, M., Hortle, E., Wong, J.J., Britton, W.J., Oehlers, S.H. (2024) Zebrafish tsc1 and cxcl12a increase susceptibility to mycobacterial infection. Life science alliance. 7(4):
- Collier, A.D., Yasmin, N., Karatayev, O., Abdulai, A.R., Yu, B., Khalizova, N., Fam, M., Leibowitz, S.F. (2023) Neuronal chemokine concentration gradients mediate effects of embryonic ethanol exposure on ectopic hypocretin/orexin neurons and behavior in zebrafish. Scientific Reports. 13:14471447
- Qian, W., Yamaguchi, N., Lis, P., Cammer, M., Knaut, H. (2023) Pulses of RhoA signaling stimulate actin polymerization and flow in protrusions to drive collective cell migration. Current biology : CB. 34(2):245-259.e8
- Shi, T., Beaulieu, M.O., Saunders, L.M., Fabian, P., Trapnell, C., Segil, N., Crump, J.G., Raible, D.W. (2023) Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes. eLIFE. 12:
- Sobah, M.L., Scott, A.C., Laird, M., Koole, C., Liongue, C., Ward, A.C. (2023) Socs3b regulates the development and function of innate immune cells in zebrafish. Frontiers in immunology. 14:11197271119727
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