Gene
h2az2a
- ID
- ZDB-GENE-020717-1
- Name
- H2A.Z variant histone 2a
- Symbol
- h2az2a Nomenclature History
- Previous Names
-
- H2A.F/Z (1)
- h2afv
- h2afva
- h2afz
- h2aza
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of chromatin. Acts upstream of or within positive regulation of melanocyte differentiation. Predicted to be located in chromosome. Predicted to be part of nucleosome. Predicted to be active in nucleus. Is expressed in ovarian follicle. Orthologous to human H2AZ2 (H2A.Z variant histone 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6908759 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Raja et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-h2az2a | Raja et al., 2020 | |
| CRISPR2-h2az2a | Raja et al., 2020 | |
| CRISPR3-h2az2a | Raja et al., 2020 | |
| CRISPR4-h2az2a | Raja et al., 2020 | |
| MO1-h2az2a | N/A | (2) |
| MO2-h2az2a | N/A | Raja et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Histone-fold | Histone H2A | Histone H2A conserved site | Histone H2A, C-terminal domain | Histone H2A/H2B/H3 |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BCB5 | InterPro | 137 | |||||
| UniProtKB:Q71PD7 | InterPro | 128 | |||||
| UniProtKB:A2BFY9 | InterPro | 128 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
h2afva-201
(1)
|
Ensembl | 831 nt | ||
| mRNA |
h2afva-202
(1)
|
Ensembl | 766 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(h2az2a:h2az2a-GFP) |
|
| 4 | (104) | |
| Tg(-1.7col2a1a:h2az2a-mCherry) |
|
| 1 | Unlu et al., 2020 | |
| Tg2(actb2:h2az2a-mCherry) |
|
| 1 | (2) | |
| Tg2(UAS:h2az2a-mCherry) |
|
| 1 | (3) | |
| Tg(4xUAS:h2az2a-23xG-EGFP) |
|
| 1 | (2) | |
| Tg(4xUAS:MYR-Tomato-h2az2a-23xG-EGFP) |
| 1 | (2) | ||
| Tg(-7.2sox10:h2az2a-Eos) |
|
| 1 | (2) | |
| Tg(actb2:h2az2a-mCherry) |
|
| 1 | (11) | |
| Tg(actc1b:h2az2a-mCherry) |
|
| 1 | (3) | |
| TgBAC2(cxcr4b:LEXPR,LEXOP:C3-2A-h2az2a-Cerulean) |
| 1 | Qian et al., 2023 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-230G14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-202N14 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6908759 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:56421 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174833 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_153644 (1) | 833 nt | ||
| Genomic | GenBank:BX322550 (2) | 158410 nt | ||
| Polypeptide | UniProtKB:A0A8M2BCB5 (1) | 137 aa |
- Casey, M.J., Chan, P.P., Li, Q., Zu, J.F., Jette, C.A., Kohler, M., Myers, B.R., Stewart, R.A. (2024) A simple and scalable zebrafish model of Sonic hedgehog medulloblastoma. Cell Reports. 43:114559114559
- Engel-Pizcueta, C., Hevia, C.F., Voltes, A., Livet, J., Pujades, C. (2024) Her9 controls the stemness properties of hindbrain boundary cells. Development (Cambridge, England). 152(1):
- Becker, C.J., Cigliola, V., Gillotay, P., Rich, A., De Simone, A., Han, Y., Di Talia, S., Poss, K.D. (2023) In toto imaging of glial JNK signaling during larval zebrafish spinal cord regeneration. Development (Cambridge, England). 150(24):
- Chen, H.J., Barske, L., Talbot, J.C., Dinwoodie, O.M., Roberts, R.R., Farmer, D.T., Jimenez, C., Merrill, A.E., Tucker, A.S., Crump, J.G. (2023) Nuclear receptor Nr5a2 promotes diverse connective tissue fates in the jaw. Developmental Cell. 58(6):461-473.e7
- Qian, W., Yamaguchi, N., Lis, P., Cammer, M., Knaut, H. (2023) Pulses of RhoA signaling stimulate actin polymerization and flow in protrusions to drive collective cell migration. Current biology : CB. 34(2):245-259.e8
- Cao, Y., Xia, Y., Balowski, J.J., Ou, J., Song, L., Safi, A., Curtis, T., Crawford, G.E., Poss, K.D., Cao, J. (2022) Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration. Development (Cambridge, England). 149(4)
- Hevia, C.F., Engel-Pizcueta, C., Udina, F., Pujades, C. (2022) The neurogenic fate of the hindbrain boundaries relies on Notch3-dependent asymmetric cell divisions. Cell Reports. 39:110915
- Sharma, B., Subramaniam, Y.J., Ayyappa Raja, D., Aggarwal, A., Sivasubbu, S., Natarajan, V.T. (2022) Reverse Genetic Approach to Identify Regulators of Pigmentation using Zebrafish. Journal of visualized experiments : JoVE. (181):
- Xia, Y., Duca, S., Perder, B., Dündar, F., Zumbo, P., Qiu, M., Yao, J., Cao, Y., Harrison, M.R.M., Zangi, L., Betel, D., Cao, J. (2022) Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration. Nature communications. 13:77047704
- Yamaguchi, N., Zhang, Z., Schneider, T., Wang, B., Panozzo, D., Knaut, H. (2022) Rear traction forces drive adherent tissue migration in vivo. Nature cell biology. 24:194-204
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