Gene
mpx
- ID
- ZDB-GENE-030131-9460
- Name
- myeloid-specific peroxidase
- Symbol
- mpx Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Enables peroxidase activity. Acts upstream of or within inflammatory response; regulation of hydrogen peroxide metabolic process; and response to bacterium. Located in cytoplasm. Is expressed in several structures, including hematopoietic cell; hematopoietic system; mesoderm; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; cystic fibrosis; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to several human genes including EPX (eosinophil peroxidase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 363 figures from 246 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1013 (3 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| gl8 | Allele with one point mutation | Unknown | Unknown | not specified | |
| ihb892Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| sa18566 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21652 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34835 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sm681 | Allele with one deletion | Exon 13 | Premature Stop | ENU | |
| t30963 | Allele with one point mutation | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mpx | Isles et al., 2021 | |
| CRISPR2-mpx | Wang et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001073 | C1q domain |
| Family | IPR019791 | Haem peroxidase, animal-type |
| Homologous_superfamily | IPR008983 | Tumour necrosis factor-like domain superfamily |
| Homologous_superfamily | IPR010255 | Haem peroxidase superfamily |
| Homologous_superfamily | IPR037120 | Haem peroxidase domain superfamily, animal type |
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Domain Details Per Protein
| Protein | Additional Resources | Length | C1q domain | Haem peroxidase, animal-type | Haem peroxidase domain superfamily, animal type | Haem peroxidase superfamily | Tumour necrosis factor-like domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q5S9 | InterPro | 892 | |||||
| UniProtKB:A0A8M1P4H4 | InterPro | 893 | |||||
| UniProtKB:Q90XS6 | InterPro | 762 | |||||
| UniProtKB:F1Q944 | InterPro | 762 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1(-8mpx:cxcr4b-EGFP) |
|
| 1 | (10) | |
| Tg(mpx:GFP) |
|
| 3 | (501) | |
| Tg2(mpx:EGFP) |
|
| 1 | Ear et al., 2015 | |
| Tg3(mpx:EGFP) |
|
| 1 | Ku et al., 2018 | |
| Tg4(mpx:EGFP) |
|
| 1 | Reinhardt et al., 2019 | |
| Tg5(mpx:EGFP) |
|
| 1 | Yuan et al., 2020 | |
| Tg6(mpx:EGFP) |
|
| 1 | Zhang et al., 2020 | |
| Tg(-8mpx:cxcr4b-EGFP) |
|
| 1 | (2) | |
| Tg(-8mpx:EGFP-CAAX) |
|
| 1 | (4) | |
| Tg(-8mpx:H2B-Cerulean-2A-mKOFP2-CAAX) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-340N8 | ZFIN Curated Data | |
| Encodes | EST | cb1013 | ||
| Encodes | EST | fj80f04 | ||
| Encodes | cDNA | MGC:65945 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85760 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212779 (1) | 3205 nt | ||
| Genomic | GenBank:CU681843 (2) | 72220 nt | ||
| Polypeptide | UniProtKB:A0A8M1P4H4 (1) | 893 aa |
No data available
- Oh, C.K., Kim, M.S., Shin, U., Kang, J.W., Kim, Y.H., Ko, H.S., Ra, J.S., Ahn, S., Choi, E.Y., Yu, S., Nam, U., Choi, T., Myung, K., Lee, Y. (2025) SMC2 and Condensin II Subunits Are Essential for the Development of Hematopoietic Stem and Progenitor Cells in Zebrafish. Journal of Cellular Physiology. 240:e70023e70023
- Ter Horst, S., Siekierska, A., De Meulemeester, A.S., Cuvry, A., Cools, L., Neyts, J., de Witte, P., Rocha-Pereira, J. (2025) The Dissemination of Rift Valley Fever Virus to the Eye and Sensory Neurons of Zebrafish Larvae Is Stat1-Dependent. Viruses. 17:
- Tesoriere, A., Ghirardo, R., Terrin, F., Sernesi, F., Meneghetti, G., Dalla Valle, L., Dinarello, A., Argenton, F. (2025) Tail Fin Regeneration in Zebrafish: The Role of Non-canonical Crosstalk Between STAT3 and Vitamin D Pathway. International journal of biological sciences. 21:271284271-284
- Xu, S., Hong, J., Dongye, M., Lin, J., Xue, R., Huang, Z., Xu, J., Zhang, Y., Leung, A.Y., Shen, J., Zhang, W., Liu, W. (2025) The synergistic effect of c-Myb hyperactivation and Pu.1 deficiency induces Pelger-Huët anomaly and promotes sAML. Proceedings of the National Academy of Sciences of the United States of America. 122:e2416121122e2416121122
- Belt, A.J., Grant, S., Tombes, R.M., Rothschild, S.C. (2024) Myeloid Targeted Human MLL-ENL and MLL-AF9 Induces cdk9 and bcl2 Expression in Zebrafish Embryos. PLoS Genetics. 20:e1011308e1011308
- Campbell, C.A., Calderon, R., Pavani, G., Cheng, X., Barakat, R., Snella, E., Liu, F., Peng, X., Essner, J.J., Dorman, K.S., McGrail, M., Gadue, P., French, D.L., Espin-Palazon, R. (2024) p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation. Nature communications. 15:77877787
- Doll, L., Welte, K., Skokowa, J., Bajoghli, B. (2024) A JAGN1-associated severe congenital neutropenia zebrafish model revealed an altered G-CSFR signaling and UPR activation. Blood advances. 8(15):4050-4065
- Han, Y., Sun, K., Yu, S., Qin, Y., Zhang, Z., Luo, J., Hu, H., Dai, L., Cui, M., Jiang, C., Liu, F., Huang, Y., Gao, P., Chen, X., Xin, T., Ren, X., Wu, X., Song, J., Wang, Q., Tang, Z., Chen, J., Zhang, H., Zhang, X., Liu, M., Luo, D. (2024) A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells. The EMBO journal. 43(10):1990-2014
- Isiaku, A.I., Zhang, Z., Pazhakh, V., Lieschke, G.J. (2024) A nox2/cybb zebrafish mutant with defective myeloid cell reactive oxygen species production displays normal initial neutrophil recruitment to sterile tail injuries. G3 (Bethesda). 14(6):
- Ketharnathan, S., Pokharel, S., Prykhozhij, S.V., Cordeiro-Santanach, A., Ban, K., Dogan, S., Hoang, H.D., Liebman, M.F., Leung, E., Alain, T., Alecu, I., Bennett, S.A.L., Čuperlović-Culf, M., Dror, Y., Berman, J.N. (2024) Loss of Dnajc21 leads to cytopenia and altered nucleotide metabolism in zebrafish. Leukemia. 38(10):2115-2126
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