Gene
cryaa
- ID
- ZDB-GENE-020508-1
- Name
- crystallin, alpha A
- Symbol
- cryaa Nomenclature History
- Previous Names
-
- [a]A-crystallin (1)
- hspb4
- wu:fc06h04
- zgc:92036
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables unfolded protein binding activity. Acts upstream of or within lens development in camera-type eye. Predicted to be active in cytoplasm and nucleus. Is expressed in eye; lens; lens epithelium; lens fiber cell; and solid lens vesicle. Used to study cataract. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Orthologous to human CRYAA (crystallin alpha A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 40 figures from 24 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92036 (4 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| asu1 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| asu4 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| la021104Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| vu532 | Allele with one deletion | Exon 1 | Premature Stop | TALEN |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cataract 9 multiple types | Alliance | Cataract 9, multiple types | 604219 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| cataract | cryaavu532/vu532 | standard conditions | Zou et al., 2015 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002068 | Alpha crystallin/Hsp20 domain |
| Domain | IPR003090 | Alpha-crystallin, N-terminal |
| Family | IPR001436 | Alpha crystallin/Small heat shock protein, animal type |
| Family | IPR055269 | Alpha crystallin/Heat shock protein Hsp-16.1/Hsp-16.2 |
| Homologous_superfamily | IPR008978 | HSP20-like chaperone |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha crystallin/Heat shock protein Hsp-16.1/Hsp-16.2 | Alpha crystallin/Hsp20 domain | Alpha-crystallin, N-terminal | Alpha crystallin/Small heat shock protein, animal type | HSP20-like chaperone |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q8UUZ6 | InterPro PDB | 173 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-1.5hsp70l:LOXP-mCherry-LOXP-Hsa.HIST1H2BJ-GFP,cryaa:Cerulean) |
|
| 1 | (10) | |
| TgBAC(cryaa:EGFP,tcf21:Cre-ERT2) |
|
| 1 | (20) | |
| Tg(cryaa:DsRed,-5.1myl7:Cre-ERT2) |
|
| 3 | (51) | |
| Tg(hsp70l:dntbx5a,cryaa:GFP) |
|
| 1 | (2) | |
| Gt(FRT-cryaa:EGFP-FRT,LOXP-LOX5171-2A-LOXP-LOX5171) |
|
| 1 | (3) | |
| Gt(FRT-cryaa:EGFP-FRT,LOXP-LOX5171-2A-TagRFP-LOXP-LOX5171) |
|
| 1 | (2) | |
| Gt(STOP,cryaa:Venus) |
|
| 2 | Zebrafish Nomenclature Committee | |
| Tg(-0.2unc45b:EGFP,cryaa:mCherry) |
|
| 1 | (2) | |
| Tg(-0.4unc45b:EGFP,cryaa:mCherry) |
|
| 1 | (2) | |
| Tg(-0.5unc45b:Hsa.ACTA1-EGFP,cryaa:mCherry) |
|
| 1 | Berger et al., 2018 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-237A6 | ZFIN Curated Data | |
| Encodes | EST | fc06h04 | ||
| Encodes | cDNA | MGC:92036 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192061 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_152950 (1) | 1430 nt | ||
| Genomic | GenBank:BX950201 (1) | 167099 nt | ||
| Polypeptide | UniProtKB:Q8UUZ6 (1) | 173 aa |
- Akhtar, M.N., Hnatiuk, A., Delgadillo-Silva, L., Geravandi, S., Sameith, K., Reinhardt, S., Bernhardt, K., Singh, S.P., Maedler, K., Brusch, L., Ninov, N. (2025) Developmental beta-cell death orchestrates the islet's inflammatory milieu by regulating immune system crosstalk. The EMBO journal. :
- Jeon, H., Jin, S., Kim, J., Joo, S., Choe, C.P. (2025) Pax1a-EphrinB2a pathway in the first pharyngeal pouch controls hyomandibular plate formation by promoting chondrocyte formation in zebrafish. Frontiers in cell and developmental biology. 13:14829061482906
- Liu, M., Li, Y., Deng, Z., Zhang, K., Huang, S., Xia, J., Feng, Y., Liang, Y., Sun, C., Liu, X., Li, S., Su, B., Dong, Y., Huang, S. (2025) Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage. Cell Death & Disease. 16:8484
- Sarich, S.C., Sreevidya, V.S., Udvadia, A.J., Svoboda, K.R., Gutzman, J.H. (2025) The transcription factor Jun is necessary for optic nerve regeneration in larval zebrafish. PLoS One. 20:e0313534e0313534
- Sebo, D.J., Ali, I., Fetsko, A.R., Trimbach, A.A., Taylor, M.R. (2025) Activation of Wnt/β-catenin in neural progenitor cells regulates blood-brain barrier development and promotes neuroinflammation. Scientific Reports. 15:34963496
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Ahuja, S., Adjekukor, C., Li, Q., Kocha, K.M., Rosin, N., Labit, E., Sinha, S., Narang, A., Long, Q., Biernaskie, J., Huang, P., Childs, S.J. (2024) The development of brain pericytes requires expression of the transcription factor nkx3.1 in intermediate precursors. PLoS Biology. 22:e3002590e3002590
- Freeburg, S.H., Shwartz, A., Kemény, L.V., Smith, C.J., Weeks, O., Miller, B.M., PenkoffLidbeck, N., Fisher, D.E., Evason, K.J., Goessling, W. (2024) Hepatocyte vitamin D receptor functions as a nutrient sensor that regulates energy storage and tissue growth in zebrafish. Cell Reports. 43:114393114393
- Herbert, M., Goosmann, C., Brinkmann, V., Dimmler, C., Cronan, M.R. (2024) Identification of a Specific Granular Marker of Zebrafish Eosinophils Enables Development of New Tools for Their Study. Journal of immunology (Baltimore, Md. : 1950). 213(12):1893-1901
- Kang, Q., Jia, J., Dean, E.D., Yuan, H., Dai, C., Li, Z., Jiang, F., Zhang, X.K., Powers, A.C., Chen, W., Li, M. (2024) ErbB3 is required for hyperaminoacidemia-induced pancreatic α cell hyperplasia. The Journal of biological chemistry. 300(8):107499
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