Fig. 5
- ID
- ZDB-FIG-250327-63
- Publication
- Kondrychyn et al., 2025 - Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis
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Aquaporin-mediated water influx increases tip cell volume. (A–C) Representative maximum intensity projection confocal z-stacks of tip cell and its 3D-volume rendering of 25 hpf wildtype (A), aqp1a.1rk28/rk28;aqp8a.1rk29/rk29 (B) and wildtype embryos overexpressing Aqp1a.1 (C) labeled with cytosolic mEmerald or EGFP. Scale bar, 10 µm. (D) Quantification of tip cell volume in 25 hpf wildtype (n = 24 cells) and aqp1a.1rk28/rk28;aqp8a.1rk29/rk29 (n = 20 cells) and wildtype overexpressing Aqp1a.1 (n = 32 cells) embryos from three independent experiments. Statistical significance was determined by Brown–Forsythe and Welch ANOVA tests. *p<0.05, **p<0.01, and ****p<0.0001. |