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ZDB-FIG-241219-68

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Ranasinghe et al., 2024 - Rotenone exposure causes features of Parkinson`s disease pathology linked with muscle atrophy in developing zebrafish embryo

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Fig. 2

Rotenone exposure prompts cascades of proinflammatory cytokines and oxidative stress in developing zebrafish embryos. Wild-type embryos aged 7–8 h post fertilization (hpf) were exposed to 30 nM rotenone until 72 hpf. The mRNA expressions of proinflammatory cytokines, (A) tnf-α (tumor necrosis factor-alpha), (B) il-1β (interleukin-1β), and (C) il-6 (interleukin-6), were measured. N = 24–30. (D) Representative image of reactive oxygen species (ROS) and (E) quantification of ROS intensity using ImageJ software. Scale bar: 1 mm. The mRNA expressions of antioxidant enzymes (F) nrf2 (nuclear factor erythroid 2-related factor 2), (G) cat (catalase), and (H) sod2 (superoxide dismutase 2), N = 24–30. Data presented as the mean ± SD. SD: standard deviation. * p < 0.05, * * p < 0.01, * ** p < 0.001, ns: not significant.

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Reprinted from Journal of hazardous materials, 480, Ranasinghe, T., Seo, Y., Park, H.C., Choe, S.K., Cha, S.H., Rotenone exposure causes features of Parkinson`s disease pathology linked with muscle atrophy in developing zebrafish embryo, 136215136215, Copyright (2024) with permission from Elsevier. Full text @ J. Hazard. Mater.