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ZDB-FIG-241219-67

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Ranasinghe et al., 2024 - Rotenone exposure causes features of Parkinson`s disease pathology linked with muscle atrophy in developing zebrafish embryo

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Fig. 1

Rotenone exposure induces toxicity in developing zebrafish embryo. Wild-type embryos aged 7–8 h post fertilization (hpf) were exposed with the indicated concentrations of rotenone. (A) Representative developmental images at 12, 36, and 48 hpf. The arrows denote yolk sac edema at 48 hpf, Scale bar: 200 µm. N = 18. (B) Mortality at 48 hpf. N = 54. Physical sizes were measured at 72 hpf according to (C), Scale bar: 1 mm. (D) Representative image of the phenotype at 72 hpf. The red arrows denote cardiac edema, and the blue arrows denote yolk sac edema. Scale bar: 1 mm. Size of body length (E), (F) yolk sac area, and (G) cardiac area were measured and quantified, N = 18. Data represented as the mean ± SD. SD: standard deviation. * * p < 0.01. ns: not significant.

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Reprinted from Journal of hazardous materials, 480, Ranasinghe, T., Seo, Y., Park, H.C., Choe, S.K., Cha, S.H., Rotenone exposure causes features of Parkinson`s disease pathology linked with muscle atrophy in developing zebrafish embryo, 136215136215, Copyright (2024) with permission from Elsevier. Full text @ J. Hazard. Mater.