FIGURE

Fig. 8

ID

ZDB-FIG-241119-17

Publication

Hoshino et al., 2024 - Pharmacological Inhibition of the Spliceosome SF3b Complex by Pladienolide-B Elicits Craniofacial Developmental Defects in Mouse and Zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 8

CNCCs migration in PB (200 nM)-treated sox10:EGFP embryos at 13 ss. (a–b) Overall defects were analyzed at 13 ss. (c–d′) Live DIC (differential interference contrast, (c), (d)) and fluorescence imaging (c′, d′) of CNCC migration in control and PB-treated embryos. The yellow arrowheads in (c) and (d) indicate the position of the midbrain-hindbrain boundary (MHB) at which CNCCs start migration. The white arrowhead in (c′) and (d′) indicates the frontier of migratory CNCCs via the frontonasal pathway. Dashed line indicates the eye (e). Scale bars: 100 μm. n = 30 for each experiment. All experiments were performed in three biological replicates.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Birth Defects Res