FIGURE

Figure 2

ID

ZDB-FIG-221018-81

Publication

Kahsay et al., 2022 - Pax3 loss of function delays tumour progression in kRAS-induced zebrafish rhabdomyosarcoma models

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Figure 2

Expression of RAS/MAPK signalling pathway linked genes in wildtype (wt) and pax3a^−/−;pax3b^−/− mutant zebrafish embryos: (A) Plots of down-regulated genes: akt1, pak1, mapk10, rps6ka1, cdc42l2, mapk8a, rac3b, akt3b, BX324164, rgl1, stat1a and gsk3ba.(B) Plots of up-regulated genes: raf1a, rps6ka3a, pak2a, FQ976913, ralbb, rac2, CR450833, pdpk1a, stat3, BX005210, BX649388, mapk12b, rhoca, cdc42l and rac1l. The normalized counts of each gene in wild type and pax3a^−/−;pax3b^−/− mutant is displayed.

Expression Data

Genes:	akt1 akt3b cdc42l2 gsk3ba mapk8a mapk10 mapk12b pak1 pak2a pdpk1a rac1l rac2 rac3b ralbb rgl1 rhoca rps6ka1 rps6ka3a stat1a stat3 (all 20)
Fish:	pax3b^umu6/umu6; pax3a^umu5/umu5
Anatomical Term:	whole organism
Stage:	High-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pax3b^umu6/umu6; pax3a^umu5/umu5
Observed In:	whole organism
Stage:	High-pec

Phenotype Detail

Acknowledgments

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