Gene

pak1

ID
ZDB-GENE-030826-29
Name
p21 protein (Cdc42/Rac)-activated kinase 1
Symbol
pak1 Nomenclature History
Previous Names
  • cb761 (1)
  • wu:fj97h10
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Enables identical protein binding activity and protein kinase activity. Acts upstream of with a positive effect on canonical Wnt signaling pathway. Acts upstream of or within several processes, including bulbus arteriosus development; embryonic organ morphogenesis; and pro-T cell differentiation. Predicted to be active in cytoplasm. Is expressed in several structures, including axial mesoderm; cardiovascular system; nervous system; neural tube; and pectoral fin. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
20 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pak1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Intellectual developmental disorder with macrocephaly, seizures, and speech delay 618158
1 - 1 of 1
Associated With pak1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000095 CRIB domain
Domain IPR000719 Protein kinase domain
Domain IPR033923 p21 activated kinase binding domain
1 - 5 of 8 Show all
Domain Details Per Protein
Protein Additional Resources Length CRIB domain CRIB domain superfamily p21 activated kinase binding domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Serine/threonine-protein kinase PAK 3-like
UniProtKB:A0A8M9P9X9 InterPro 587
UniProtKB:Q803Z0 InterPro 577
UniProtKB:A0A8M9PFA6 InterPro 579
1 - 3 of 3
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA pak1-201 (1)
Ensembl
Ensembl 5,736 nt
ZFIN BLAST
mRNA pak1-202 (1)
Ensembl
Ensembl 1,740 nt
ZFIN BLAST
mRNA pak1-203 (1)
Ensembl
Ensembl 5,712 nt
ZFIN BLAST
mRNA pak1-204 (1)
Ensembl
Ensembl 5,736 nt
ZFIN BLAST
mRNA pak1-205 (1)
Ensembl
Ensembl 5,736 nt
ZFIN BLAST
1 - 5 of 5
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pak Rabbit
  • IHC
 2
1 - 1 of 1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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