Gene
akt1
- ID
- ZDB-GENE-130730-1
- Name
- v-akt murine thymoma viral oncogene homolog 1
- Symbol
- akt1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within negative regulation of neuron differentiation and regulation of blood vessel endothelial cell differentiation. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; hindbrain neural rod; pharyngeal arch; solid lens vesicle; and somite. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 6; breast cancer (multiple); gastrointestinal system cancer (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Cheng et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| breast cancer | Alliance | Breast cancer, somatic | 114480 |
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| Cowden syndrome 6 | Alliance | Cowden syndrome 6 | 615109 |
| ovarian cancer | Alliance | Ovarian cancer, somatic | 167000 |
| Proteus syndrome | Alliance | Proteus syndrome, somatic mosaic | 176920 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR017892 | Protein kinase, C-terminal |
| Domain | IPR039026 | Protein Kinase B, pleckstrin homology domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase, ATP binding site | Protein Kinase B, pleckstrin homology domain | Protein kinase, C-terminal | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:M4MD44 | InterPro PDB | 474 |
- Genome Browsers
Interactions and Pathways
Plasmids
No data available