Gene
stat1a
- ID
- ZDB-GENE-980526-499
- Name
- signal transducer and activator of transcription 1a
- Symbol
- stat1a Nomenclature History
- Previous Names
-
- stat1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; regulation of transcription by RNA polymerase II; and response to peptide hormone. Predicted to be located in nucleoplasm. Predicted to be part of ISGF3 complex. Predicted to be active in cytoplasm and nucleus. Is expressed in blood; kidney; retina; spleen; and telencephalon. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); breast cancer (multiple); immunodeficiency 31A; immunodeficiency 31B; and immunodeficiency 31C. Orthologous to human STAT1 (signal transducer and activator of transcription 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| lv50 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-stat1a | Zhou et al., 2018 | |
| CRISPR2-stat1a | (2) | |
| MO1-stat1a | N/A | (2) |
| MO2-stat1a | N/A | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| chronic mucocutaneous candidiasis | Alliance | Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant | 614162 |
| immunodeficiency 31A | Alliance | Immunodeficiency 31A, mycobacteriosis, autosomal dominant | 614892 |
| immunodeficiency 31B | Alliance | Immunodeficiency 31B, mycobacterial and viral infections, autosomal recessive | 613796 |
| immunodeficiency 31C | Alliance | Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant | 614162 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000980 | SH2 domain |
| Domain | IPR013799 | STAT transcription factor, protein interaction |
| Domain | IPR013800 | STAT transcription factor, all-alpha domain |
| Domain | IPR013801 | STAT transcription factor, DNA-binding |
| Domain | IPR022752 | Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | p53-like transcription factor, DNA-binding domain superfamily | SH2 domain | SH2 domain superfamily | Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal | Signal transducer and activator of transcription, linker domain | STAT1, C-terminal domain superfamily | STAT1, SH2 domain | STAT transcription factor, all-alpha domain | STAT transcription factor, coiled coil | STAT transcription factor, DNA-binding | STAT transcription factor, DNA-binding, N-terminal | STAT transcription factor, N-terminal domain superfamily | STAT transcription factor, protein interaction | Transcription factor STAT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:O93598 | InterPro | 749 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
stat1a-201
(1)
|
Ensembl | 4,430 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-84A8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73305 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131480 (1) | 2520 nt | ||
| Genomic | GenBank:BX548072 (1) | 188936 nt | ||
| Polypeptide | UniProtKB:O93598 (1) | 749 aa |
- Liu, M., Li, Y., Deng, Z., Zhang, K., Huang, S., Xia, J., Feng, Y., Liang, Y., Sun, C., Liu, X., Li, S., Su, B., Dong, Y., Huang, S. (2025) Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage. Cell Death & Disease. 16:8484
- McLaurin, D.M., Tucker, S.K., Siddique, S.J., Challagundla, L., Gibert, Y., Hebert, M.D. (2025) A Novel Role for Coilin in Vertebrate Innate Immunity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 39:e70580e70580
- Ter Horst, S., Siekierska, A., De Meulemeester, A.S., Cuvry, A., Cools, L., Neyts, J., de Witte, P., Rocha-Pereira, J. (2025) The Dissemination of Rift Valley Fever Virus to the Eye and Sensory Neurons of Zebrafish Larvae Is Stat1-Dependent. Viruses. 17:
- Weiss, A., D'Amata, C., Pearson, B.J., Hayes, M.N. (2024) A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCAH1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo. eLIFE. 13:
- Grabinski, S.E., Parsana, D., Perkins, B.D. (2023) Comparative analysis of transcriptional changes in zebrafish cep290 and bbs2 mutants by RNA-seq reveals upregulation of inflammatory and stress-related pathways. Frontiers in molecular neuroscience. 16:11488401148840
- Park, K.H., Makki, H.M.M., Kim, S.H., Chung, H.J., Jung, J. (2023) Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 166:115350115350
- Wu, J., Li, J., Chen, K., Liu, G., Zhou, Y., Chen, W., Zhu, X., Ni, T.T., Zhang, B., Jin, D., Li, D., Kang, L., Wu, Y., Zhu, P., Xie, P., Zhong, T.P. (2023) Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation. Proceedings of the National Academy of Sciences of the United States of America. 120:e2209062120e2209062120
- Ding, Y., Lang, D., Yan, J., Bu, H., Li, H., Jiao, K., Yang, J., Ni, H., Morotti, S., Le, T., Clark, K.J., Port, J., Ekker, S.C., Cao, H., Zhang, Y., Wang, J., Grandi, E., Li, Z., Shi, Y., Li, Y., Glukhov, A.V., Xu, X. (2022) A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. eLIFE. 11:
- Hason, M., Mikulasova, T., Machonova, O., Pombinho, A.R., van Ham, T.J., Irion, U., Nüsslein-Volhard, C., Bartunek, P., Svoboda, O. (2022) M-CSFR/CSF1R signaling regulates myeloid fates in zebrafish via distinct action of its receptors and ligands. Blood advances. 6(5):1474-1488
- Kahsay, A., Rodriguez-Marquez, E., López-Pérez, A., Hörnblad, A., von Hofsten, J. (2022) Pax3 loss of function delays tumour progression in kRAS-induced zebrafish rhabdomyosarcoma models. Scientific Reports. 12:17149
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