Gene

stat1a

ID
ZDB-GENE-980526-499
Name
signal transducer and activator of transcription 1a
Symbol
stat1a Nomenclature History
Previous Names
  • stat1
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; regulation of transcription by RNA polymerase II; and response to peptide hormone. Predicted to act upstream of or within regulation of DNA-templated transcription and signal transduction. Predicted to be located in nucleoplasm. Predicted to be part of ISGF3 complex. Predicted to be active in cytoplasm and nucleus. Is expressed in blood; kidney; retina; spleen; and telencephalon. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); breast cancer (multiple); immunodeficiency 31A; immunodeficiency 31B; and immunodeficiency 31C. Orthologous to human STAT1 (signal transducer and activator of transcription 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
No data available
Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-stat1a
    Zhou et al., 2018
    CRISPR2-stat1a
      (2)
      MO1-stat1aN/A (2)
      MO2-stat1aN/A (3)
      1 - 4 of 4
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      Human Disease
      Associated With stat1a Human Ortholog
      Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
      chronic mucocutaneous candidiasis Alliance Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant 614162
      immunodeficiency 31A Alliance Immunodeficiency 31A, mycobacteriosis, autosomal dominant 614892
      immunodeficiency 31B Alliance Immunodeficiency 31B, mycobacterial and viral infections, autosomal recessive 613796
      immunodeficiency 31C Alliance Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant 614162
      1 - 4 of 4
      Associated With stat1a Via Experimental Models
      No data available
      Gene Ontology
      Protein Domains
      Domain, Family, and Site Summary
      Type InterPro ID Name
      Domain IPR000980 SH2 domain
      Domain IPR013799 STAT transcription factor, protein interaction
      Domain IPR013800 STAT transcription factor, all-alpha domain
      Domain IPR013801 STAT transcription factor, DNA-binding
      Domain IPR022752 Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal
      1 - 5 of 14 Show all
      Domain Details Per Protein
      Protein Additional Resources Length p53-like transcription factor, DNA-binding domain superfamily SH2 domain SH2 domain superfamily Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal Signal transducer and activator of transcription, linker domain STAT1, C-terminal domain superfamily STAT1, SH2 domain STAT transcription factor, all-alpha domain STAT transcription factor, coiled coil STAT transcription factor, DNA-binding STAT transcription factor, DNA-binding, N-terminal STAT transcription factor, N-terminal domain superfamily STAT transcription factor, protein interaction Transcription factor STAT
      UniProtKB:O93598 InterPro 749
      1 - 1 of 1
      Transcripts
      Genome Browsers
      Genome Build: GRCz11Chromosome: 22
      Type Name Annotation Method Has Havana Data Length (nt) Analysis
      mRNA stat1a-201 (1) Ensembl 4,430 nt
      1 - 1 of 1
      Interactions and Pathways
      No data available
      Antibodies
      No data available
      Plasmids
      No data available
      Constructs
      No data available
      Marker Relationships
      Relationship Marker Type Marker Accession Numbers Citations
      Contained inBACDKEYP-84A8ZFIN Curated Data
      EncodescDNAMGC:73305ZFIN Curated Data
      1 - 2 of 2
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      Sequences
      Orthology
      Comparative Orthology
      Alliance
      Gene Tree
      Ensembl
      Species Symbol Chromosome Accession # Evidence
      HumanSTAT12
      Amino acid sequence comparison (6)
      Conserved genome location (synteny) (2)
      Functional complementation (1)
      MouseStat11
      Amino acid sequence comparison (3)
      Conserved genome location (synteny) (1)
      Citations
      1 - 10 of 50
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