Gene
stat3
- ID
- ZDB-GENE-980526-68
- Name
- signal transducer and activator of transcription 3 (acute-phase response factor)
- Symbol
- stat3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic morphogenesis; liver development; and neuron development. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including blastomere; bone tissue; epidermal superficial stratum; head; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 63 figures from 39 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55197 (9 images)
- eu734 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ia23 | Allele with one delins | Unknown | Premature Stop | CRISPR | |
ihb211 | Allele with one delins | Unknown | Unknown | CRISPR | |
ihb212 | Allele with one deletion | Unknown | Unknown | CRISPR | |
mdu35 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
mdu36 | Allele with one deletion | Exon 20 | Unknown | CRISPR | |
sa938 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa10162 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa12185 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa15744 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa16856 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
hyper IgE recurrent infection syndrome 1 | Alliance | Hyper-IgE syndrome 1, autosomal dominant, with recurrent infections | 147060 |
Autoimmune disease, multisystem, infantile-onset, 1 | 615952 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | p53-like transcription factor, DNA-binding domain superfamily | SH2 domain | SH2 domain superfamily | Signal transducer and activator of transcription, linker domain | STAT3, SH2 domain | STAT transcription factor, all-alpha domain | STAT transcription factor, coiled coil | STAT transcription factor, DNA-binding | STAT transcription factor, DNA-binding, N-terminal | STAT transcription factor, N-terminal domain superfamily | STAT transcription factor, protein interaction | Transcription factor STAT |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2BB24 | InterPro | 821 | ||||||||||||
UniProtKB:A0A8M2BAX1 | InterPro | 801 | ||||||||||||
UniProtKB:A0A8M2BBA1 | InterPro | 753 | ||||||||||||
UniProtKB:O93599 | InterPro | 806 | ||||||||||||
UniProtKB:A0A0R4IGF2 | InterPro | 738 |
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Interactions and Pathways
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(7xstat3-HSV.Ul23:EGFP) |
|
| Zebrafish Nomenclature Committee | ||
Tg(actb2:LOXP-DsRed-STOP-LOXP-dnstat3-GFP) |
| 1 | (5) | ||
Tg(gfap:stat3-EGFP) |
|
| 1 | (7) | |
Tg(hsp70l:ca-stat3) |
|
| 1 | Palsamy et al., 2023 | |
Tg(ubb:LOXP-DsRed-LOXP-HA-dnstat3) |
| 1 | (2) | ||
Tg(ubb:LOXP-DsRed-LOXP-HA-stat3) |
| 1 | (2) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-209D14 | ZFIN Curated Data | |
Encodes | EST | eu734 | Thisse et al., 2005 | |
Encodes | EST | fc15d02 | ZFIN Curated Data | |
Encodes | EST | fl59g06 | ZFIN Curated Data | |
Encodes | cDNA | MGC:55197 | ZFIN Curated Data | |
Encodes | cDNA | MGC:85598 | ZFIN Curated Data | |
Encodes | cDNA | MGC:193054 | ZFIN Curated Data |
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- Tesoriere, A., Ghirardo, R., Terrin, F., Sernesi, F., Meneghetti, G., Dalla Valle, L., Dinarello, A., Argenton, F. (2025) Tail Fin Regeneration in Zebrafish: The Role of Non-canonical Crosstalk Between STAT3 and Vitamin D Pathway. International journal of biological sciences. 21:271284271-284
- Dong, Y., Yang, Y., Wang, H., Feng, D., Nist, E., Yapundich, N., Spurlock, B., Craft, M., Qian, L., Liu, J. (2024) Single-cell chromatin profiling reveals genetic programs activating proregenerative states in nonmyocyte cells. Science advances. 10:eadk4694
- Jędrychowska, J., Vardanyan, V., Wieczor, M., Marciniak, A., Czub, J., Amini, R., Jain, R., Shen, H., Choi, H., Kuznicki, J., Korzh, V. (2024) Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development. Developmental Biology. 513:50-62
- Shin, K., Rodriguez-Parks, A., Kim, C., Silaban, I.M., Xia, Y., Sun, J., Dong, C., Keles, S., Wang, J., Cao, J., Kang, J. (2024) Harnessing the regenerative potential of interleukin11 to enhance heart repair. Nature communications. 15:96669666
- Sobah, M.L., Liongue, C., Ward, A.C. (2024) Stat3 regulates developmental hematopoiesis and impacts myeloid cell function via canonical and non-canonical modalities. Journal of Innate Immunity. 16(1):262-282
- Ulhaq, Z.S., Tse, W.K.F. (2024) PFHxS Exposure and the Risk of Non-Alcoholic Fatty Liver Disease. Genes. 15(1):
- Xu, H., Cao, L., Chen, Y., Zhou, C., Xu, J., Zhang, Z., Li, X., Liu, L., Lu, J. (2024) Single-cell RNA sequencing reveals the heterogeneity and interactions of immune cells and Müller glia during zebrafish retina regeneration. Neural regeneration research. :
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Emmerich, K., Walker, S.L., Wang, G., White, D.T., Ceisel, A., Wang, F., Teng, Y., Chunawala, Z., Graziano, G., Nimmagadda, S., Saxena, M.T., Qian, J., Mumm, J.S. (2023) Transcriptomic comparison of two selective retinal cell ablation paradigms in zebrafish reveals shared and cell-specific regenerative responses. PLoS Genetics. 19:e1010905e1010905
- Fontana, C.M., Terrin, F., Facchinello, N., Meneghetti, G., Dinarello, A., Gambarotto, L., Zuccarotto, A., Caichiolo, M., Brocca, G., Verin, R., Nazio, F., Carnevali, O., Cecconi, F., Bonaldo, P., Dalla Valle, L. (2023) Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction. Biological research. 56:1919
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