ZFIN Morpholino: MO1-wnt8a

Target Location

Genome Build: GRCz11Chromosome: 14

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-wnt8a

No data available

Phenotype

Phenotype resulting from MO1-wnt8a

Phenotype	Fish	Figures
embryonic heart tube left/right pattern formation disrupted, abnormal	TL + MO1-wnt8a	Fig. 1 , Fig. 3 from Lin et al., 2009
heart looping disrupted, abnormal	TL + MO1-wnt8a	Fig. 1 from Lin et al., 2009
Kupffer's vesicle cilium decreased length, abnormal	TL + MO1-wnt8a	Fig. 2 from Lin et al., 2009
neural crest cell morphology, abnormal	WT + MO1-wnt8a	Fig. 3 from Dutta et al., 2010
neural crest cell differentiation disrupted, abnormal	WT + MO1-wnt8a	Fig. 3 from Dutta et al., 2010

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Phenotype of all Fish created by or utilizing MO1-wnt8a

Phenotype	Fish	Conditions	Figures
whole organism decreased length, abnormal	AB + MO1-wnt8a + MO2-wnt8a	standard conditions	Fig. 1 from Thorpe et al., 2005
tail bud decreased length, abnormal	AB + MO1-wnt8a + MO2-wnt8a	standard conditions	Fig. 1 from Thorpe et al., 2005
tail bud morphology, abnormal	AB + MO1-wnt8a + MO2-wnt8a	standard conditions	Fig. 4 from Thorpe et al., 2005
post-vent region decreased length, abnormal	AB + MO1-wnt8a + MO2-wnt8a	standard conditions	Fig. 1 from Thorpe et al., 2005
post-anal tail morphogenesis disrupted, abnormal	AB + MO1-wnt8a + MO2-wnt8a	standard conditions	Fig. 1 from Thorpe et al., 2005

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Citations

Include unpublished citations

He, M., Zhang, R., Jiao, S., Zhang, F., Ye, D., Wang, H., Sun, Y. (2020) Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors. PLoS Biology. 18:e3000561
He, X., Zhang, W., Yan, C., Nie, F., Li, C., Liu, X., Fei, C., Li, S., Song, X., Jia, Y., Zeng, R., Wu, D., Pan, W., Hao, X., Li, L. (2017) Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity. Cell discovery. 3:17003
Hübner, K., Grassme, K.S., Rao, J., Wenke, N.K., Zimmer, C.L., Korte, L., Mu Ller, K., Sumanas, S., Greber, B., Herzog, W. (2017) Wnt Signaling Positively Regulates Endothelial Cell Fate Specification in the Fli1a-Positive Progenitor Population via Lef1. Developmental Biology. 430(1):142-155
Mandal, A., Holowiecki, A., Song, Y.C., Waxman, J.S. (2017) Wnt signaling balances specification of the cardiac and pharyngeal muscle fields. Mechanisms of Development. 143:32-41
Naylor, R.W., Han, H.I., Hukriede, N.A., Davidson, A.J. (2017) Wnt8a expands the pool of embryonic kidney progenitors in zebrafish. Developmental Biology. 425(2):130-141
Dutta, S., Sriskanda, S., Boobalan, E., Alur, R.P., Elkahloun, A., Brooks, B.P. (2015) nlz1 Is required for cilia formation in zebrafish embryogenesis. Developmental Biology. 406(2):203-11
Stanganello, E., Hagemann, A.I., Mattes, B., Sinner, C., Meyen, D., Weber, S., Schug, A., Raz, E., Scholpp, S. (2015) Filopodia-based Wnt transport during vertebrate tissue patterning. Nature communications. 6:5846
Lu, F.I., Sun, Y.H., Wei, C.Y., Thisse, C., Thisse, B. (2014) Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/β-catenin pathway. Nature communications. 5:5368
Wylie, A.D., Fleming, J.A., Whitener, A.E., and Lekven, A.C. (2014) Post-transcriptional regulation of wnt8a is essential to zebrafish axis development. Developmental Biology. 386(1):53-63
Guan, R., Ei-Rass, S., Spillane, D., Lam, S., Wang, Y., Wu, J., Chen, Z., Wang, A., Jia, Z., Keating, A., Hu, J., and Wen, X.Y. (2013) rbm 47, a novel RNA binding protein, regulates zebrafish head development. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(12):1395-404

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