Gene
rarab
- ID
- ZDB-GENE-980526-72
- Name
- retinoic acid receptor, alpha b
- Symbol
- rarab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and pectoral fin development. Acts upstream of or within liver development; midbrain-hindbrain boundary development; and secondary heart field specification. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including endoderm; hindbrain neural keel; mesoderm; nervous system; and neural plate. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia; lung carcinoma (multiple); and syndromic microphthalmia 12. Orthologous to several human genes including RARA (retinoic acid receptor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 40 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu883 (15 images)
- eu941 (15 images)
- l03399 (37 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la015178Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la015179Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024132Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024134Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028902Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa20057 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20058 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 7 of 7
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-rarab | N/A | (7) |
| MO2-rarab | N/A | D'Aniello et al., 2013 |
| MO3-rarab | N/A | Samarut et al., 2014 |
| MO4-rarab | N/A | Samarut et al., 2014 |
1 - 4 of 4
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute promyelocytic leukemia | Alliance | Leukemia, acute promyelocytic | 612376 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR047158 | Retinoic acid receptor, ligand-binding domain |
| Domain | IPR047159 | Retinoic acid receptor, DNA-binding domain |
| Family | IPR001723 | Nuclear hormone receptor |
1 - 5 of 8 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Retinoic acid receptor | Retinoic acid receptor, DNA-binding domain | Retinoic acid receptor, ligand-binding domain | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZTI3 | InterPro | 458 | ||||||||
| UniProtKB:E7EZ95 | InterPro | 460 |
1 - 2 of 2
Interactions and Pathways
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-196P24 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-242N9 | ZFIN Curated Data | |
| Encodes | EST | eu883 | Thisse et al., 2005 | |
| Encodes | EST | eu941 | Thisse et al., 2005 | |
| Encodes | EST | fj66e06 | ||
| Encodes | EST | l03399 | (2) | |
| Encodes | cDNA | MGC:55278 | ZFIN Curated Data |
1 - 7 of 7
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131399 (1) | 2795 nt | ||
| Genomic | GenBank:CR392003 (2) | 182043 nt | ||
| Polypeptide | UniProtKB:E7EZ95 (1) | 460 aa |
- Gray, R., Lovely, C.B. (2024) Redefining retinoic acid receptor expression in zebrafish embryos using Hybridization Chain Reaction. Differentiation; research in biological diversity. 140:100822
- Zeng, T., Lv, J., Liang, J., Xie, B., Liu, L., Tan, Y., Zhu, J., Jiang, J., Xie, H. (2024) Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway. Frontiers in cell and developmental biology. 12:13813621381362
- Prendergast, A.E., Jim, K.K., Marnas, H., Desban, L., Quan, F.B., Djenoune, L., Laghi, V., Hocquemiller, A., Lunsford, E.T., Roussel, J., Keiser, L., Lejeune, F.X., Dhanasekar, M., Bardet, P.L., Levraud, J.P., van de Beek, D., Vandenbroucke-Grauls, C.M.J.E., Wyart, C. (2023) CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Current biology : CB. 33(5):940-956.e10
- Paulissen, E., Palmisano, N.J., Waxman, J., Martin, B.L. (2022) Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis. eLIFE. 11:
- Rodrigues, P., Cunha, V., Ferreira, M., Armanda Reis-Henriques, M., Oliva-Teles, L., Guimarães, L., Paulo Carvalho, A. (2022) Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine. Water. 14(3):417
- Zhang, W., Scerbo, P., Delagrange, M., Candat, V., Mayr, V., Vriz, S., Distel, M., Ducos, B., Bensimon, D. (2022) Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis. Communications biology. 5:113
- Rodrigues, P., Cunha, V., Oliva-Teles, L., Ferreira, M., Guimarães, L. (2020) Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment. Journal of hazardous materials. 400:123171
- Dohn, T.E., Ravisankar, P., Tirera, F.T., Martin, K.E., Gafranek, J.T., Duong, T.B., VanDyke, T.L., Touvron, M., Barske, L.A., Crump, J.G., Waxman, J.S. (2019) Nr2f-dependent allocation of ventricular cardiomyocyte and pharyngeal muscle progenitors. PLoS Genetics. 15:e1007962
- Kalaskar, V.K., Alur, R.P., Li, L.K., Thomas, J.W., Sergeev, Y.V., Blain, D., Hufnagel, R.B., Cogliati, T., Brooks, B.P. (2019) High-throughput custom capture sequencing identifies novel mutations in coloboma-associated genes: Mutation in DNA-binding domain of retinoic acid receptor beta affects nuclear localization causing ocular coloboma. Human Mutation. 41(3):678-695
- Song, Y.C., Dohn, T.E., Rydeen, A.B., Nechiporuk, A.V., Waxman, J.S. (2019) HDAC1-mediated repression of the retinoic acid-responsive gene ripply3 promotes second heart field development. PLoS Genetics. 15:e1008165
1 - 10 of 55
Show