Gene
actb2
- ID
- ZDB-GENE-000329-3
- Name
- actin, beta 2
- Symbol
- actb2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Predicted to be located in several cellular components, including cytoskeleton; dense body; and focal adhesion. Predicted to be active in actin filament. Is expressed in several structures, including brain; eye; integument; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; autosomal dominant nonsyndromic deafness 20; and thrombocytopenia. Orthologous to several human genes including ACTB (actin beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56040 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-actb2 | Parvez et al., 2021 | |
| CRISPR2-actb2 | Parvez et al., 2021 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Baraitser-Winter syndrome 1 | Alliance | Baraitser-Winter syndrome 1 | 243310 |
| Becker nevus, syndromic or isolated, somatic mosaic | 604919 | ||
| Congenital smooth muscle hamartoma with or without hemihypertrophy, somatic mosaic | 620470 | ||
| Dystonia-deafness syndrome 1 | 607371 | ||
| Thrombocytopenia 8, with dysmorphic features and developmental delay | 620475 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Actin/actin-like conserved site | Actin, conserved site | Actin family | ATPase, nucleotide binding domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q7ZVF9 | InterPro | 375 | ||||
| UniProtKB:A8WG05 | InterPro | 375 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-5actb2:cetn4-GFP) |
|
| 1 | (15) | |
| Tg(-9.8actb2:LOXP-DsRed-LOXP-EGFP) |
|
| 1 | (31) | |
| Tg(actb2:EGFP) |
|
| 1 | (23) | |
| Tg(actb2:LOXP-STOP-LOXP-DsRedEx) |
|
| 1 | (28) | |
| Tg(actb2:mCherry,myl7:EGFP) |
|
| 1 | (7) | |
| Tg(actb2:Mmu.Arl13b-GFP) |
|
| 1 | (59) | |
| Tg(actb2:pxn-EGFP) |
|
| 1 | (9) | |
| Tg(Xla.Eef1a1-actb2:LOXP-LOX5171-FRT-F3-EGFP,mCherry) |
|
| 3 | (14) | |
| Tg2(actb2:EGFP-CAAX) |
|
| 1 | (7) | |
| Tg2(actb2:h2az2a-mCherry) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-255L18 | ZFIN Curated Data | |
| Encodes | EST | fa56g06 | ZFIN Curated Data | |
| Encodes | EST | fb38a10 | ZFIN Curated Data | |
| Encodes | EST | fj16d08 | ||
| Encodes | cDNA | MGC:56040 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85665 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:172104 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192911 | ZFIN Curated Data | |
| Has Artifact | EST | fb12f11 | ||
| Is Hybridized by | EST | fj81g03 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_181601 (1) | 1786 nt | ||
| Genomic | GenBank:AL929031 (2) | 187548 nt | ||
| Polypeptide | UniProtKB:A8WG05 (1) | 375 aa |
- Ge, S., Liu, Y., Huang, H., Yu, J., Li, X., Lin, Q., Huang, P., Mei, J. (2025) Chr23-miR-200s and Dmrt1 Control Sexually Dimorphic Trade-Off Between Reproduction and Growth in Zebrafish. International Journal of Molecular Sciences. 26:
- He, X., Wang, Z., Cheng, L., Wang, H., Sun, Y. (2025) An antagonistic role of clock genes and lima1 in kidney regeneration. Communications biology. 8:2929
- Liu, B., Wang, P., Lv, X. (2025) Phytol-mixed micelles alleviate dexamethasone-induced osteoporosis in zebrafish: Activation of the MMP3-OPN-MAPK pathway-mediating bone remodeling. Open life sciences. 20:2022101520221015
- Du, Q., Shao, R., Wang, W., Zhang, H., Liao, X., Wang, Z., Yin, Z., Ai, Q., Mai, K., Tang, X., Wan, M. (2024) Vitamin D3 Regulates Energy Homeostasis under Short-Term Fasting Condition in Zebrafish (Danio Rerio). Nutrients. 16(9):
- Morikawa, M., Yamaguchi, H., Kikkawa, M. (2024) Calaxin is a key factor for calcium-dependent waveform control in zebrafish sperm. Life science alliance. 7(9):
- Revenu, C., Lebreton, C., Cannata Serio, M., Rosello, M., Duclaux-Loras, R., Duroure, K., Nicolle, O., Eggeler, F., Prospéri, M.T., Stoufflet, J., Vougny, J., Lépine, P., Michaux, G., Cerf-Bensussan, N., Coudrier, E., Perez, F., Parlato, M., Del Bene, F. (2024) Myosin 1b regulates intestinal epithelial morphogenesis via interaction with UNC45A. Cell Reports. 43:114941114941
- Shin, K., Rodriguez-Parks, A., Kim, C., Silaban, I.M., Xia, Y., Sun, J., Dong, C., Keles, S., Wang, J., Cao, J., Kang, J. (2024) Harnessing the regenerative potential of interleukin11 to enhance heart repair. Nature communications. 15:96669666
- Silva, M.G.F.R., Luchiari, A.C., Medeiros, I., de Souza, A.M., Serquiz, A.C., Martins, F.F., Moura, S.A.B., Camillo, C.S., Medeiros, S.R.B., Pais, T.D.S., Passos, T.S., Galeno, D.M.L., Morais, A.H.A. (2024) Evaluation of the Effects of Diet-Induced Obesity in Zebrafish (Danio rerio): A Comparative Study. Nutrients. 16(19):
- Sun, Y., Chen, Z., Jin, M., Xie, H., Zhao, C. (2024) Ciliary length regulation by intraflagellar transport in zebrafish. eLIFE. 13:
- Wang, M., Zhao, S., Shi, C., Guyot, M.C., Liao, M., Tauer, J.T., Willie, B.M., Cobetto, N., Aubin, C.É., Küster-Schöck, E., Drapeau, P., Zhang, J., Wu, N., Kibar, Z. (2024) Planar cell polarity zebrafish models of congenital scoliosis reveal novel underlying defects in notochord morphogenesis. Development (Cambridge, England). 151(21):
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