Gene

hsp70l

ID
ZDB-GENE-050321-1
Name
heat shock cognate 70-kd protein, like
Symbol
hsp70l Nomenclature History
Previous Names
  • hsp70-4 (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Acts upstream of or within several processes, including definitive hemopoiesis; response to cadmium ion; and response to heat. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in lens. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Orthologous to several human genes including HSPA1L (heat shock protein family A (Hsp70) member 1 like); HSPA1A (heat shock protein family A (Hsp70) member 1A); and HSPA1B (heat shock protein family A (Hsp70) member 1B).
Genome Resources
Note
The promoter region of this gene is used in most "hsp70" transgenic lines.
Comparative Information
Expression
All Expression Data
25 figures from 22 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
No data available
Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-hsp70l
    Putri et al., 2018
    CRISPR2-hsp70l
      Ye et al., 2019
      MO1-hsp70lN/A (3)
      1 - 3 of 3
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      Human Disease
      Associated With hsp70l Human Ortholog
      No data available
      Associated With hsp70l Via Experimental Models
      No data available
      Gene Ontology
      Protein Domains
      Domain, Family, and Site Summary
      Type InterPro ID Name
      Conserved_site IPR018181 Heat shock protein 70, conserved site
      Family IPR013126 Heat shock protein 70 family
      Homologous_superfamily IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
      Homologous_superfamily IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
      Homologous_superfamily IPR043129 ATPase, nucleotide binding domain
      1 - 5 of 5
      Domain Details Per Protein
      Protein Additional Resources Length ATPase, nucleotide binding domain Heat shock protein 70, conserved site Heat shock protein 70 family Heat shock protein 70kD, C-terminal domain superfamily Heat shock protein 70kD, peptide-binding domain superfamily
      UniProtKB:A8WFS0 InterPro 643
      1 - 1 of 1
      Transcripts
      Genome Browsers
      Genome Build: GRCz11Chromosome: 8
      Type Name Annotation Method Has Havana Data Length (nt) Analysis
      mRNA hsp70l-201 (1) Ensembl 2,302 nt
      1 - 1 of 1
      Interactions and Pathways
      No data available
      Antibodies
      No data available
      Plasmids
      Constructs
      Construct Regulatory Region Coding Sequence Species Tg Lines Citations
      Et(-1.5hsp70l:GAL4-VP16)
      • hsp70l
      • Danio rerio
      23 (40)
      Et(hsp70l:GFP-GAL4FF)
      • hsp70l
      • Danio rerio
      32 (15)
      Tg(-1.5hsp70l:GAL4)
      • hsp70l
      • Danio rerio
      1 (141)
      Tg(-1.5hsp70l:LOXP-mCherry-LOXP-Hsa.HIST1H2BJ-GFP,cryaa:Cerulean)
      • Danio rerio
      • Homo sapiens
      1 (10)
      Tg1(hsp70l:fgf8a)
      • hsp70l
      • Danio rerio
      1 (21)
      Tg(hsp70l:bmp2b)
      • hsp70l
      • Danio rerio
      1 (51)
      Tg(hsp70l:dkk1b-GFP)
      • hsp70l
      • Danio rerio
      1 (114)
      Tg(hsp70l:dnfgfr1a-EGFP)
      • hsp70l
      • Danio rerio
      1 (114)
      Tg(hsp70l:dntbx5a,cryaa:GFP)
      • Danio rerio
      1 (2)
      Tg(hsp70l:dnXla.Bmpr1a-GFP)
      • hsp70l
      • Danio rerio
      1 (54)
      1 - 10 of 764
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      Marker Relationships
      Relationship Marker Type Marker Accession Numbers Citations
      Contained inBACCH73-267A10ZFIN Curated Data
      EncodescDNAMGC:171403ZFIN Curated Data
      EncodescDNAMGC:198181ZFIN Curated Data
      EncodescDNAMGC:198207ZFIN Curated Data
      1 - 4 of 4
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      Sequences
      Orthology
      Comparative Orthology
      Alliance
      Gene Tree
      Ensembl
      No data available
      Citations
      1 - 10 of 650
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