Gene
hsp70l
- ID
- ZDB-GENE-050321-1
- Name
- heat shock cognate 70-kd protein, like
- Symbol
- hsp70l Nomenclature History
- Previous Names
-
- hsp70-4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Acts upstream of or within several processes, including definitive hemopoiesis; response to cadmium ion; and response to heat. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in lens. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Orthologous to several human genes including HSPA1L (heat shock protein family A (Hsp70) member 1 like); HSPA1A (heat shock protein family A (Hsp70) member 1A); and HSPA1B (heat shock protein family A (Hsp70) member 1B).
- Genome Resources
- Note
-
The promoter region of this gene is used in most "hsp70" transgenic lines.
- Comparative Information
-
- All Expression Data
- 25 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-hsp70l | Putri et al., 2018 | |
CRISPR2-hsp70l | Ye et al., 2019 | |
MO1-hsp70l | N/A | (3) |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018181 | Heat shock protein 70, conserved site |
Family | IPR013126 | Heat shock protein 70 family |
Homologous_superfamily | IPR029047 | Heat shock protein 70kD, peptide-binding domain superfamily |
Homologous_superfamily | IPR029048 | Heat shock protein 70kD, C-terminal domain superfamily |
Homologous_superfamily | IPR043129 | ATPase, nucleotide binding domain |
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Domain Details Per Protein
Protein | Additional Resources | Length | ATPase, nucleotide binding domain | Heat shock protein 70, conserved site | Heat shock protein 70 family | Heat shock protein 70kD, C-terminal domain superfamily | Heat shock protein 70kD, peptide-binding domain superfamily |
---|---|---|---|---|---|---|---|
UniProtKB:A8WFS0 | InterPro | 643 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
hsp70l-201
(1)
|
Ensembl | 2,302 nt |
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Interactions and Pathways
No data available
Plasmids
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Et(-1.5hsp70l:GAL4-VP16) |
|
| 23 | (40) | |
Et(hsp70l:GFP-GAL4FF) |
|
| 32 | (15) | |
Tg(-1.5hsp70l:GAL4) |
|
| 1 | (141) | |
Tg(-1.5hsp70l:LOXP-mCherry-LOXP-Hsa.HIST1H2BJ-GFP,cryaa:Cerulean) |
|
| 1 | (10) | |
Tg1(hsp70l:fgf8a) |
|
| 1 | (21) | |
Tg(hsp70l:bmp2b) |
|
| 1 | (51) | |
Tg(hsp70l:dkk1b-GFP) |
|
| 1 | (114) | |
Tg(hsp70l:dnfgfr1a-EGFP) |
|
| 1 | (114) | |
Tg(hsp70l:dntbx5a,cryaa:GFP) |
|
| 1 | (2) | |
Tg(hsp70l:dnXla.Bmpr1a-GFP) |
|
| 1 | (54) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-267A10 | ZFIN Curated Data | |
Encodes | cDNA | MGC:171403 | ZFIN Curated Data | |
Encodes | cDNA | MGC:198181 | ZFIN Curated Data | |
Encodes | cDNA | MGC:198207 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001113589 (1) | 2316 nt | ||
Genomic | GenBank:BX323451 (1) | 211489 nt | ||
Polypeptide | UniProtKB:A8WFS0 (1) | 643 aa |
No data available
- Hu, M., Veldman, M.B. (2025) Srebf2 mediates successful optic nerve axon regeneration via the mevalonate synthesis pathway. Molecular neurodegeneration. 20:2828
- Jeon, H., Jin, S., Kim, J., Joo, S., Choe, C.P. (2025) Pax1a-EphrinB2a pathway in the first pharyngeal pouch controls hyomandibular plate formation by promoting chondrocyte formation in zebrafish. Frontiers in cell and developmental biology. 13:14829061482906
- Liu, M., Li, Y., Deng, Z., Zhang, K., Huang, S., Xia, J., Feng, Y., Liang, Y., Sun, C., Liu, X., Li, S., Su, B., Dong, Y., Huang, S. (2025) Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage. Cell Death & Disease. 16:8484
- Ma, J., Chen, Y., Song, J., Ruan, Q., Li, L., Luo, L. (2025) Establishment and application of a zebrafish model of Werner syndrome identifies sapanisertib as a potential antiaging drug. Proceedings of the National Academy of Sciences of the United States of America. 122:e2413719122e2413719122
- Sarich, S.C., Sreevidya, V.S., Udvadia, A.J., Svoboda, K.R., Gutzman, J.H. (2025) The transcription factor Jun is necessary for optic nerve regeneration in larval zebrafish. PLoS One. 20:e0313534e0313534
- Xiao, H., Li, M., Zhong, Y., Patel, A., Xu, R., Zhang, C., Athey, T.W., Fang, S., Xu, T., Du, S. (2025) Hsf1 is essential for proteotoxic stress response in smyd1b-deficient embryos and fish survival under heat shock. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 39:e70283e70283
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Ahuja, S., Adjekukor, C., Li, Q., Kocha, K.M., Rosin, N., Labit, E., Sinha, S., Narang, A., Long, Q., Biernaskie, J., Huang, P., Childs, S.J. (2024) The development of brain pericytes requires expression of the transcription factor nkx3.1 in intermediate precursors. PLoS Biology. 22:e3002590e3002590
- Bongiovanni, C., Bueno-Levy, H., Posadas Pena, D., Del Bono, I., Miano, C., Boriati, S., Da Pra, S., Sacchi, F., Redaelli, S., Bergen, M., Romaniello, D., Pontis, F., Tassinari, R., Kellerer, L., Petraroia, I., Mazzeschi, M., Lauriola, M., Ventura, C., Heermann, S., Weidinger, G., Tzahor, E., D'Uva, G. (2024) BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice. Cell Reports. 43:114162114162
- Burrows, D.J., McGown, A., Abduljabbar, O., Castelli, L.M., Shaw, P.J., Hautbergue, G.M., Ramesh, T.M. (2024) RAN Translation of C9orf72-Related Dipeptide Repeat Proteins in Zebrafish Recapitulates Hallmarks of Amyotrophic Lateral Sclerosis and Identifies Hypothermia as a Therapeutic Strategy. Annals of neurology. 96(6):1058-1069
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