Gene
hsp70l
- ID
- ZDB-GENE-050321-1
- Name
- heat shock cognate 70-kd protein, like
- Symbol
- hsp70l Nomenclature History
- Previous Names
-
- hsp70-4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Acts upstream of or within several processes, including definitive hemopoiesis; response to cadmium ion; and response to heat. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in lens. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Orthologous to several human genes including HSPA1L (heat shock protein family A (Hsp70) member 1 like); HSPA1A (heat shock protein family A (Hsp70) member 1A); and HSPA1B (heat shock protein family A (Hsp70) member 1B).
- Genome Resources
- Note
-
The promoter region of this gene is used in most "hsp70" transgenic lines.
- Comparative Information
-
- All Expression Data
- 25 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hsp70l | Putri et al., 2018 | |
| CRISPR2-hsp70l | Ye et al., 2019 | |
| MO1-hsp70l | N/A | (3) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018181 | Heat shock protein 70, conserved site |
| Family | IPR013126 | Heat shock protein 70 family |
| Homologous_superfamily | IPR029047 | Heat shock protein 70kD, peptide-binding domain superfamily |
| Homologous_superfamily | IPR029048 | Heat shock protein 70kD, C-terminal domain superfamily |
| Homologous_superfamily | IPR043129 | ATPase, nucleotide binding domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ATPase, nucleotide binding domain | Heat shock protein 70, conserved site | Heat shock protein 70 family | Heat shock protein 70kD, C-terminal domain superfamily | Heat shock protein 70kD, peptide-binding domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A8WFS0 | InterPro | 643 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hsp70l-201
(1)
|
Ensembl | 2,302 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Et(-1.5hsp70l:GAL4-VP16) |
|
| 23 | (40) | |
| Et(hsp70l:GFP-GAL4FF) |
|
| 32 | (15) | |
| Tg(-1.5hsp70l:GAL4) |
|
| 1 | (141) | |
| Tg(-1.5hsp70l:LOXP-mCherry-LOXP-Hsa.HIST1H2BJ-GFP,cryaa:Cerulean) |
|
| 1 | (10) | |
| Tg1(hsp70l:fgf8a) |
|
| 1 | (21) | |
| Tg(hsp70l:bmp2b) |
|
| 1 | (51) | |
| Tg(hsp70l:dkk1b-GFP) |
|
| 1 | (116) | |
| Tg(hsp70l:dnfgfr1a-EGFP) |
|
| 1 | (114) | |
| Tg(hsp70l:dntbx5a,cryaa:GFP) |
|
| 1 | (2) | |
| Tg(hsp70l:dnXla.Bmpr1a-GFP) |
|
| 1 | (54) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-267A10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171403 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198181 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198207 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113589 (1) | 2316 nt | ||
| Genomic | GenBank:BX323451 (1) | 211489 nt | ||
| Polypeptide | UniProtKB:A8WFS0 (1) | 643 aa |
No data available
- Hu, M., Veldman, M.B. (2025) Srebf2 mediates successful optic nerve axon regeneration via the mevalonate synthesis pathway. Molecular neurodegeneration. 20:2828
- Huang, D., Kapadia, E.H., Liang, Y., Shriver, L.P., Dai, S., Patti, G.J., Humbel, B.M., Laudet, V., Parichy, D.M. (2025) Agouti and BMP signaling drive a naturally occurring fate conversion of melanophores to leucophores in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 122:e2424180122e2424180122
- Jeon, H., Jin, S., Kim, J., Joo, S., Choe, C.P. (2025) Pax1a-EphrinB2a pathway in the first pharyngeal pouch controls hyomandibular plate formation by promoting chondrocyte formation in zebrafish. Frontiers in cell and developmental biology. 13:14829061482906
- Kanai, S.M., Garcia, C.R., Augustus, M.R., Sharafeldeen, S.A., Brooks, E.P., Sucharov, J., Lencer, E.S., Nichols, J.T., Clouthier, D.E. (2025) The Gq/11 family of Gα subunits is necessary and sufficient for lower jaw development. Development (Cambridge, England). :
- Liu, M., Li, Y., Deng, Z., Zhang, K., Huang, S., Xia, J., Feng, Y., Liang, Y., Sun, C., Liu, X., Li, S., Su, B., Dong, Y., Huang, S. (2025) Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage. Cell Death & Disease. 16:8484
- Ma, J., Chen, Y., Song, J., Ruan, Q., Li, L., Luo, L. (2025) Establishment and application of a zebrafish model of Werner syndrome identifies sapanisertib as a potential antiaging drug. Proceedings of the National Academy of Sciences of the United States of America. 122:e2413719122e2413719122
- Sarich, S.C., Sreevidya, V.S., Udvadia, A.J., Svoboda, K.R., Gutzman, J.H. (2025) The transcription factor Jun is necessary for optic nerve regeneration in larval zebrafish. PLoS One. 20:e0313534e0313534
- Schloss, S.S., Marshall, Z.Q., Santistevan, N.J., Gjorcheska, S., Stenzel, A., Barske, L., Nelson, J.C. (2025) Cadherin-16 regulates acoustic sensory gating in zebrafish through endocrine signaling. PLoS Biology. 23:e3003164e3003164
- Xiao, H., Li, M., Zhong, Y., Patel, A., Xu, R., Zhang, C., Athey, T.W., Fang, S., Xu, T., Du, S. (2025) Hsf1 is essential for proteotoxic stress response in smyd1b-deficient embryos and fish survival under heat shock. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 39:e70283e70283
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
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