Gene
wt1a
- ID
- ZDB-GENE-980526-558
- Name
- WT1 transcription factor a
- Symbol
- wt1a Nomenclature History
- Previous Names
-
- wt1
- zwt1
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including kidney development; regulation of blood-brain barrier permeability; and visceral serous pericardium development. Predicted to be located in cytoplasm; nuclear speck; and nucleolus. Is expressed in several structures, including cardiovascular system; central nervous system; mesoderm; renal system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma (multiple); and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 111 figures from 69 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu357 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-wt1a | Hopfenmüller et al., 2022 | |
| CRISPR2-wt1a | Boezio et al., 2022 | |
| CRISPR3-wt1a | Boezio et al., 2022 | |
| CRISPR4-wt1a | Boezio et al., 2022 | |
| MO1-wt1a | N/A | (2) |
| MO2-wt1a | N/A | (7) |
| MO3-wt1a | N/A | (4) |
| MO4-wt1a | N/A | (2) |
| MO5-wt1a | N/A | Schnerwitzki et al., 2014 |
| MO6-wt1a,wt1b | N/A | Tomar et al., 2014 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Denys-Drash syndrome | Alliance | Denys-Drash syndrome | 194080 |
| Frasier syndrome | Alliance | Frasier syndrome | 136680 |
| malignant mesothelioma | Alliance | Mesothelioma, somatic | 156240 |
| nephroblastoma | Alliance | Wilms tumor, type 1 | 194070 |
| nephrotic syndrome type 4 | Alliance | Nephrotic syndrome, type 4 | 256370 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Wilm's tumour protein, N-terminal | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|
| UniProtKB:Q9PUT7 | InterPro | 419 | |||
| UniProtKB:A0AB32TC13 | InterPro | 416 | |||
| UniProtKB:A0AB32TC36 | InterPro | 418 | |||
| UniProtKB:A0AB32TEZ4 | InterPro | 415 | |||
| UniProtKB:A0AB32THJ0 | InterPro | 381 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1(-6.8wt1a:EGFP) |
|
| 3 | (7) | |
| Tg2(-6.8wt1a:EGFP) |
|
| 3 | (2) | |
| Tg(-6.8wt1a:Cre-ERT2) |
|
| 1 | (6) | |
| Tg(-35.1wt1a:EGFP) |
|
| 3 | (12) | |
| Tg(actb2:LOXP-DsRed2-LOXP-EGFP-2A-wt1a) |
| 1 | (2) | ||
| TgBAC(wt1a:GAL4FF) |
|
| 1 | Nishimura et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-152I22 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-114A13 | ZFIN Curated Data | |
| Encodes | EST | eu357 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:193986 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193994 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131046 (1) | 1932 nt | ||
| Genomic | GenBank:BX322616 (1) | 232304 nt | ||
| Polypeptide | UniProtKB:Q9PUT7 (1) | 419 aa |
- Carver, J.J., Amato, C.M., Yao, H., Zhu, Y. (2024) Adamts9 is required for the development of primary ovarian follicles and maintenance of female sex in zebrafish. Biology of reproduction. 111(5):1107-1128
- Miller, B.M., Goessling, W. (2024) The proteasome subunit psmb1 is essential for craniofacial cartilage maturation and morphogenesis. JCI insight. 9(16):
- Pollitt, E.J.G., Sánchez-Posada, J., Snashall, C.M., Derrick, C.J., Noël, E.S. (2024) Llgl1 mediates timely epicardial emergence and establishment of an apical laminin sheath around the trabeculating cardiac ventricle. Development (Cambridge, England). 151(13):
- Ahmed, I., Ziab, M., Da'as, S., Hasan, W., Jeya, S.P., Aliyev, E., Nisar, S., Bhat, A.A., Fakhro, K.A., Alshabeeb Akil, A.S. (2023) Network-based identification and prioritization of key transcriptional factors of diabetic kidney disease. Computational and structural biotechnology journal. 21:716730716-730
- Belcher, B., Vestal, J., Lane, S., Kell, M., Smith, L., Camarata, T. (2023) The zebrafish paralog six2b is required for early proximal pronephros morphogenesis. Scientific Reports. 13:1969919699
- Boezio, G.L.M., Zhao, S., Gollin, J., Priya, R., Mansingh, S., Guenther, S., Fukuda, N., Gunawan, F., Stainier, D.Y.R. (2022) The developing epicardium regulates cardiac chamber morphogenesis by promoting cardiomyocyte growth. Disease models & mechanisms. 16(5):
- Drummond, B.E., Chambers, B.E., Wesselman, H.M., Gibson, S., Arceri, L., Ulrich, M.N., Gerlach, G.F., Kroeger, P.T., Leshchiner, I., Goessling, W., Wingert, R.A. (2022) osr1 Maintains Renal Progenitors and Regulates Podocyte Development by Promoting wnt2ba via the Antagonism of hand2. Biomedicines. 10(11):
- Habicher, J., Manuel, R., Pedroni, A., Ferebee, C., Ampatzis, K., Boije, H. (2022) A new transgenic reporter line reveals expression of protocadherin 9 at a cellular level within the zebrafish central nervous system. Gene expression patterns : GEP. 44:119246
- Hopfenmüller, V.L., Perner, B., Reuter, H., Bates, T.J.D., Große, A., Englert, C. (2022) The Wilms Tumor Gene wt1a Contributes to Blood-Cerebrospinal Fluid Barrier Function in Zebrafish. Frontiers in cell and developmental biology. 9:809962
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
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