Gene
tcf21
- ID
- ZDB-GENE-051113-88
- Name
- transcription factor 21
- Symbol
- tcf21 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and protein dimerization activity. Acts upstream of or within artery development and branchiomeric skeletal muscle development. Located in nucleus. Is expressed in cardiovascular system; head muscle; mesenchymal cell; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in coronary artery disease and ventricular septal defect. Orthologous to human TCF21 (transcription factor 21).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns427 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sk1 | Allele with one deletion | Exon 1 | Frameshift | TALEN | |
| tpl118Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| tpl119 | unknown | Unknown | Unknown | CRISPR | |
| tpl120 | unknown | Unknown | Unknown | CRISPR | |
| tpl144Tg | Transgenic insertion | 5' UTR | Unknown | DNA and CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | E-box Binding Transcriptional Regulators | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|---|
| UniProtKB:Q32PV5 | InterPro | 176 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(cryaa:EGFP,tcf21:Cre-ERT2) |
|
| 1 | (20) | |
| TgBAC(tcf21:DsRed2) |
|
| 1 | (34) | |
| TgBAC(tcf21:LOXP-BFP-LOXP-mCherry-NTR) |
|
| 1 | Xia et al., 2022 | |
| TgBAC(tcf21:mCherry-NTR) |
|
| 1 | (17) | |
| TgBAC(tcf21:MYR-EGFP) |
|
| 1 | Weinberger et al., 2020 | |
| TgBAC(tcf21:MYR-tdTomato) |
|
| 1 | Weinberger et al., 2020 | |
| TgBAC(tcf21:NLS-EGFP) |
|
| 1 | (36) | |
| Tg(tcf21:Dendra2) |
|
| 1 | Weinberger et al., 2020 | |
| Tg(tcf21:GAL4-VP16-Bmo.Ecr,UAS:EGFP) |
|
| 1 | (3) | |
| Tg(tcf21:GFP) |
|
| 1 | Meng et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-79F12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:123313 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001037681 (1) | 1063 nt | ||
| Genomic | GenBank:CR759830 (1) | 196033 nt | ||
| Polypeptide | UniProtKB:Q32PV5 (1) | 176 aa |
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Dong, Y., Yang, Y., Wang, H., Feng, D., Nist, E., Yapundich, N., Spurlock, B., Craft, M., Qian, L., Liu, J. (2024) Single-cell chromatin profiling reveals genetic programs activating proregenerative states in nonmyocyte cells. Science advances. 10:eadk4694
- Xiao, C., Hou, J., Wang, F., Song, Y., Zheng, J., Luo, L., Wang, J., Ding, W., Zhu, X., Xiong, J.W. (2023) Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration. NPJ Regenerative medicine. 8:2121
- Boezio, G.L.M., Zhao, S., Gollin, J., Priya, R., Mansingh, S., Guenther, S., Fukuda, N., Gunawan, F., Stainier, D.Y.R. (2022) The developing epicardium regulates cardiac chamber morphogenesis by promoting cardiomyocyte growth. Disease models & mechanisms. 16(5):
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Marques, I.J., Ernst, A., Arora, P., Vianin, A., Hetke, T., Sanz-Morejón, A., Naumann, U., Odriozola, A., Langa, X., Andrés-Delgado, L., Zuber, B., Torroja, C., Osterwalder, M., Simões, F., Englert, C., Mercader, N. (2022) WT1 transcription factor impairs cardiomyocyte specification and drives a phenotypic switch from myocardium to epicardium. Development (Cambridge, England). 149(6):
- Sun, J., Peterson, E.A., Wang, A.Z., Ou, J., Smith, K.E., Poss, K.D., Wang, J. (2022) hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration. Circulation. 146(1):48-63
- Wasserman, A.H., Huang, A.R., Lewis-Israeli, Y.R., Dooley, M.D., Mitchell, A.L., Venkatesan, M., Aguirre, A. (2022) Oxytocin promotes epicardial cell activation and heart regeneration after cardiac injury. Frontiers in cell and developmental biology. 10:985298
- Xia, Y., Duca, S., Perder, B., Dündar, F., Zumbo, P., Qiu, M., Yao, J., Cao, Y., Harrison, M.R.M., Zangi, L., Betel, D., Cao, J. (2022) Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration. Nature communications. 13:77047704
- de Bakker, D.E.M., Bouwman, M., Dronkers, E., Simões, F.C., Riley, P.R., Goumans, M.J., Smits, A.M., Bakkers, J. (2021) Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration. Development (Cambridge, England). 148(19):
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