FIGURE

Figure 4

ID

ZDB-FIG-250709-60

Publication

Galuh et al., 2025 - The glucocorticoid receptor is affected by its target ZBTB16 in a dissociated manner

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Figure 4

Modulation of GR-mediated transactivation and transrepression of genes by zbtb16ab in zebrafish larvae. Five dpf WT zebrafish larvae and zbtb16ab crispants (n = 10–30) were treated with vehicle or 5 μg/mL cortisol for 20 h. Cortisol-induced GR target genes are indicated in the first panels at the upper row: (A) fkbp5 (P = 0.0002), (B) gilz (P = 0.01), (C) pck1 (P = 0.001). (D) Total glucose levels (mean ± S.E.M) from whole-body lysates of either 5 dpf WT zebrafish larvae or zbtb16ab crispants, with increased levels in the cortisol-treated crispants (P = 0.0002). The lower row shows the relative gene expression of GR-repressive genes: (E) nr3c1, (F) il6, (G) pparg, (H) il8 (P = 0.02). The relative gene expression was normalized to actb as a housekeeping gene. Data are presented in geometric means ± geometric S.D. G: genotype, I: interaction, ns: not significant, T: treatment.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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