Gene

fkbp5

ID
ZDB-GENE-030616-630
Name
FKBP prolyl isomerase 5
Symbol
fkbp5 Nomenclature History
Previous Names
  • si:zc263a23.8
  • wu:fc31g11
  • wu:fl87b03
  • zgc:64082
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Is expressed in gut; head; liver; and regenerating fin. Human ortholog(s) of this gene implicated in alcohol dependence; heroin dependence; and major depressive disorder. Orthologous to human FKBP5 (FKBP prolyl isomerase 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
25 figures from 18 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ihbwyy7Allele with one deletionExon 3UnknownCRISPR
sa12885Allele with one point mutationUnknownSplice SiteENU
sa15952Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
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Human Disease
Associated With fkbp5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
melancholic depression Alliance {Major depressive disorder and accelerated response to antidepressant drug treatment} 608516
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Associated With fkbp5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
Family IPR050754 Peptidyl-prolyl cis-trans isomerase FKBP4/5/8-like
Homologous_superfamily IPR011990 Tetratricopeptide-like helical domain superfamily
Homologous_superfamily IPR046357 Peptidyl-prolyl cis-trans isomerase domain superfamily
Repeat IPR019734 Tetratricopeptide repeat
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Domain Details Per Protein
Protein Additional Resources Length FKBP-type peptidyl-prolyl cis-trans isomerase domain Peptidyl-prolyl cis-trans isomerase domain superfamily Peptidyl-prolyl cis-trans isomerase FKBP4/5/8-like Tetratricopeptide-like helical domain superfamily Tetratricopeptide repeat
UniProtKB:A0A8M3ATH6 InterPro 326
UniProtKB:Q801U5 InterPro 453
UniProtKB:A0A8M2BDK0 InterPro 477
UniProtKB:A0A8M9QF85 InterPro 457
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 6
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA fkbp5-201 (1) Ensembl 2,613 nt
mRNA fkbp5-203 (1) Ensembl 3,634 nt
ncRNA fkbp5-002 (1) Ensembl 917 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-263A23ZFIN Curated Data
EncodesESTfc31g11ZFIN Curated Data
EncodesESTfl87b03ZFIN Curated Data
EncodescDNAMGC:64082ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanFKBP56
Amino acid sequence comparison (1)
Citations
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