Gene
cxcl8a
- ID
- ZDB-GENE-081104-317
- Name
- chemokine (C-X-C motif) ligand 8a
- Symbol
- cxcl8a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables chemokine activity. Acts upstream of or within several processes, including blood vessel morphogenesis; endothelial to hematopoietic transition; and hematopoietic stem cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including eye; heart; liver; pleuroperitoneal region; and ventral wall of dorsal aorta. Used to study vitamin D-dependent rickets. Human ortholog(s) of this gene implicated in several diseases, including acute pyelonephritis; autoimmune uveitis; gastritis (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human CXCL8 (C-X-C motif chemokine ligand 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 90 figures from 65 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| vitamin D-dependent rickets | cxcl8auwm25/uwm25 | standard conditions | Cortes et al., 2016 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Chemokine beta/gamma/delta | Chemokine interleukin-8-like domain | Chemokine interleukin-8-like superfamily | CXC chemokine | CXC Chemokine domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0G2KYH9 | InterPro | ||||||
| UniProtKB:A0A8M3B7M3 | InterPro | 97 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cxcl8a-201
(1)
|
Ensembl | 716 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
- Deng, D., Zhao, B., Yang, H., Wang, S., Geng, Z., Zhou, J., Yang, G., Han, L. (2025) Investigating the Effect and Potential Mechanism of Rhamnetin 3-O-α-Rhamnoside on Acute Liver Injury In Vivo and In Vitro. Pharmaceuticals (Basel, Switzerland). 18:
- Deng, L., Feng, Z., Li, X., Fan, L., Wu, X., Tavakoli, S., Zhu, Y., Ye, H., Wu, K. (2025) Exploring the potential mechanism of B-phycoerythrin on DSS-induced colitis and colitis-associated bone loss based on network pharmacology, molecular docking, and experimental validation. Scientific Reports. 15:54555455
- Liu, L., Hu, W., Kerman, F.D., Spaink, H.P. (2025) Toll-like receptor adaptor protein TIRAP has specialized roles in signaling, metabolic control and leukocyte migration upon wounding in zebrafish larvae. International journal of biological sciences. 21:823841823-841
- Ye, J., Lu, L., Rui, X.H., Ren, M.D., Tu, F., Shang, Z.B., Liu, J. (2025) Zebrafish as a model for investigating Klebsiella pneumoniae-driven lung injury and therapeutic targets. Experimental Lung Research. 51:112211-22
- Arroyo, A.B., Tyrkalska, S.D., Bastida-Martínez, E., Monera-Girona, A.J., Cantón-Sandoval, J., Bernal-Carrión, M., García-Moreno, D., Elías-Arnanz, M., Mulero, V. (2024) Peds1 deficiency in zebrafish results in myeloid cell apoptosis and exacerbated inflammation. Cell death discovery. 10:388388
- Brenet, A., Somkhit, J., Csaba, Z., Ciura, S., Kabashi, E., Yanicostas, C., Soussi-Yanicostas, N. (2024) Microglia Mitigate Neuronal Activation in a Zebrafish Model of Dravet Syndrome. Cells. 13(8):
- Brix, A., Belleri, L., Pezzotta, A., Pettinato, E., Mazzola, M., Zoccolillo, M., Marozzi, A., Monteiro, R., Del Bene, F., Mortellaro, A., Pistocchi, A. (2024) ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish. Communications biology. 7:615615
- Cao, Y., Xu, F., Xia, Q., Liu, K., Lin, H., Zhang, S., Zhang, Y. (2024) The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways. Marine drugs. 22(3):
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Leiba, J., Sipka, T., Begon-Pescia, C., Bernardello, M., Tairi, S., Bossi, L., Gonzalez, A.A., Mialhe, X., Gualda, E., Loza-Alvarez, P., Blanc-Potard, A., Lutfalla, G., Nguyen-Chi, M.E. (2024) Dynamics of macrophage polarization support Salmonella persistence in a whole living organism. eLIFE. 13:
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