FIGURE

Figure 7

ID

ZDB-FIG-250109-86

Publication

Wilson et al., 2024 - Zebrafish are resilient to the loss of major diacylglycerol acyltransferase enzymes

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Figure 7

Loss of triacylglycerol synthesis enzymes sometimes alters yolk sac morphology.A,B, representative images of mogat3b^c858;dgat2^sa13945 mutants (A) and mogat3b^c862;dgat2^sa13945 mutants (B) with short (top) or no (bottom) yolk extensions (YE) at 3 dpf. Arrows indicate where the yolk extension should be located. Scale = 200 μm. C, all mogat3b^c858;dgat2^sa13945 mutants initially have a YE, but the YE can be lost as the embryo develops (arrows). However, the gut develops normally (6 dpf), and sometimes large residual lipid droplets are noted (arrowheads). Scale = 200 μm. D, The percentage of embryos per clutch exhibiting abnormal yolk extension morphology (lack of YE, short YE, broken YE) on 3 dpf from in-crosses of the noted parental genotypes (N = 4–9 clutches per genotype (clutch size ranged from 20 to 300 embryos)).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dgat2^{sa13945/sa13945} dgat2^{sa13945/sa13945}; mogat3b^c858/c858 dgat2^{sa13945/sa13945}; mogat3b^c862/c862
Observed In:	extension
Stage Range:	Long-pec to Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Biol. Chem.