FIGURE

Fig. 5

ID

ZDB-FIG-190717-5

Publication

Zhang et al., 2019 - Establishment of a zebrafish hematological disease model induced by 1,4-benzoquinone

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Fig. 5

BQ-induced neutrophil expansion was blocked in c-myb-deficient mutants. (A–I) Expression of the neutrophil markers lyz (A,B) (sibling control group n=65, BQ group n=38; mutant control group n=25, BQ group n=35) and mpx (C,D) (sibling control group n=83, BQ group n=47; mutant control group n=31, BQ group n=16) was analyzed using WISH, and SB staining (E,F) (sibling control group n=54, BQ group n=18; mutant control group n=25, BQ group n=22) was detected, in c-myb^hkz3/+ intercrossed progenies in BQ-treated groups (right column) and untreated controls (left column). Signals increased following BQ exposure at 3 dpf in siblings (A,C,E) but were unaltered in c-myb^hkz3/hkz3 mutants (B,D,F). The red boxed regions show magnified views of the CHT. (G–I) Quantification of WISH and SB staining for panels A–F (Student's t-test, mean±s.d., **P<0.01, ****P<0.0001; ns, non-significant).

Expression Data

Genes:	lyz mpx
Fish:	WT myb^hkz3/hkz3
Condition:	chemical treatment by environment: 1,4-benzoquinone
Anatomical Terms:	caudal hematopoietic tissue neutrophil
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT myb^hkz3/hkz3
Condition:	chemical treatment by environment: 1,4-benzoquinone
Observed In:	caudal hematopoietic tissue neutrophil
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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