Gene
lyz
- ID
- ZDB-GENE-020515-2
- Name
- lysozyme
- Symbol
- lyz Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable lysozyme activity. Involved in cell maturation. Is expressed in several structures, including cardiovascular system; hematopoietic cell; hematopoietic system; mesoderm; and pleuroperitoneal region. Orthologous to several human genes including LYZ (lysozyme); LYZL1 (lysozyme like 1); and LYZL2 (lysozyme like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 150 figures from 102 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Amyloidosis, hereditary systemic 5 | 620658 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glycoside hydrolase, family 22 | Glycoside hydrolase family 22 domain | Glycoside hydrolase, family 22, lysozyme | Lysozyme-like domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q90YS5 | InterPro | 151 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(lyz:DsRed2) |
|
| 1 | (244) | |
| Tg(lyz:EGFP) |
|
| 1 | (122) | |
| Tg(-2.4lyz:EGFP) |
|
| 4 | (8) | |
| Tg2(lyz:EGFP) |
|
| 1 | Gao et al., 2018 | |
| Tg(-4.1lyz:EGFP) |
|
| 1 | (21) | |
| Tg(lyz:akt2-EGFP) |
|
| 1 | (5) | |
| Tg(lyz:BFP) |
|
| 1 | (10) | |
| Tg(lyz:Cas9-CRISPR1-mfn2-CRISPR2-mfn2-CRISPR3-mfn2-CRISPR4-mfn2) |
|
| 1 | (2) | |
| Tg(lyz:Cas9-CRISPR1-opa1-CRISPR2-opa1) |
|
| 1 | (2) | |
| Tg(lyz:Cas9-CRISPR2-mfn2) |
|
| 1 | (2) |
1 - 10 of 76
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-80N22 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136734 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194008 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_139180 (1) | 596 nt | ||
| Genomic | GenBank:CT574587 (1) | 160942 nt | ||
| Polypeptide | UniProtKB:Q90YS5 (1) | 151 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | LYZ | 12 | Amino acid sequence comparison (2) |
- Xu, S., Hong, J., Dongye, M., Lin, J., Xue, R., Huang, Z., Xu, J., Zhang, Y., Leung, A.Y., Shen, J., Zhang, W., Liu, W. (2025) The synergistic effect of c-Myb hyperactivation and Pu.1 deficiency induces Pelger-Huët anomaly and promotes sAML. Proceedings of the National Academy of Sciences of the United States of America. 122:e2416121122e2416121122
- Ye, Y., Zhao, Z., Mo, W., Liu, W., Wu, L., Li, J., Zhang, W., Huang, Z., Wang, S. (2025) Zebrafish modeling of atypical PML-RARA isoform from acute promyelocytic leukemia patient and its implications for clinical treatment. Annals of Hematology. :
- Belt, A.J., Grant, S., Tombes, R.M., Rothschild, S.C. (2024) Myeloid Targeted Human MLL-ENL and MLL-AF9 Induces cdk9 and bcl2 Expression in Zebrafish Embryos. PLoS Genetics. 20:e1011308e1011308
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Doll, L., Welte, K., Skokowa, J., Bajoghli, B. (2024) A JAGN1-associated severe congenital neutropenia zebrafish model revealed an altered G-CSFR signaling and UPR activation. Blood advances. 8(15):4050-4065
- Gimenez, G., Kalev-Zylinska, M.L., Morison, I., Bohlander, S.K., Horsfield, J.A., Antony, J. (2024) Cohesin rad21 mutation dysregulates erythropoiesis and granulopoiesis output within the whole kidney marrow of adult zebrafish. American journal of physiology. Cell physiology. 328(1):C9-C19
- Han, Y., Sun, K., Yu, S., Qin, Y., Zhang, Z., Luo, J., Hu, H., Dai, L., Cui, M., Jiang, C., Liu, F., Huang, Y., Gao, P., Chen, X., Xin, T., Ren, X., Wu, X., Song, J., Wang, Q., Tang, Z., Chen, J., Zhang, H., Zhang, X., Liu, M., Luo, D. (2024) A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells. The EMBO journal. 43(10):1990-2014
- Huang, W., Yue, Y., Hao, W., Zhang, Z., Cai, P., Yang, D. (2024) mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish. Stem Cell Reports. 19(9):1277-1288
- Isiaku, A.I., Zhang, Z., Pazhakh, V., Lieschke, G.J. (2024) A nox2/cybb zebrafish mutant with defective myeloid cell reactive oxygen species production displays normal initial neutrophil recruitment to sterile tail injuries. G3 (Bethesda). 14(6):
- Jia-Xin, H., Song'en, X., Wen-Qing, Z., Wei, L. (2024) The interaction of Pu.1 and cMyb in zebrafish neutrophil development. Yi chuan = Hereditas. 46:319332319-332
1 - 10 of 305
Show