Gene
opn1sw1
- ID
- ZDB-GENE-991109-25
- Name
- opsin 1 (cone pigments), short-wave-sensitive 1
- Symbol
- opn1sw1 Nomenclature History
- Previous Names
-
- SWS1 (1)
- uvops
- zfuv
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled photoreceptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to light stimulus; and detection of light stimulus. Predicted to act upstream of or within signal transduction and visual perception. Predicted to be located in membrane. Predicted to be active in photoreceptor outer segment and plasma membrane. Is expressed in several structures, including digestive system; endocrine system; heart; photoreceptor cell; and visual system. Human ortholog(s) of this gene implicated in blue color blindness. Orthologous to human OPN1SW (opsin 1, short wave sensitive).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 92 figures from 63 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73050 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Yoshimatsu et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-opn1sw1 | Lu et al., 2023 | |
| CRISPR2-opn1sw1 | Lu et al., 2023 | |
| MO1-opn1sw1 | N/A | Yoshimatsu et al., 2014 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| blue color blindness | Alliance | Colorblindness, tritan | 190900 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G-protein coupled receptor opsins | G protein-coupled receptor, rhodopsin-like | Opsin | Opsin, blue sensitive | Visual pigments (opsins) retinal binding site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9W6A9 | InterPro | 336 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
opn1sw1-201
(1)
|
Ensembl | 1,777 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-opn1sw1 |
|
ABclonal
|
1 | ||||
| Ab1-opn1sw1 | polyclonal | Rabbit |
|
43 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-5.5opn1sw1:EGFP) |
|
| 1 | (51) | |
| Tg(-5.5opn1sw1:Eos) |
|
| 1 | Nunley et al., 2020 | |
| Tg(opn1sw1:FLAG-Mmu.Nrl) |
|
| 1 | Oel et al., 2020 | |
| Tg(opn1sw1:GAL4-VP16) |
|
| 1 | (4) | |
| Tg(opn1sw1:h2az2a-YFP) |
|
| 1 | (4) | |
| Tg(opn1sw1:KALTA4) |
|
| 1 | (3) | |
| Tg(opn1sw1:mCherry) |
|
| 1 | Campbell et al., 2017 | |
| Tg(opn1sw1:nrl) |
|
| 1 | Oel et al., 2020 | |
| Tg(opn1sw1:NTR-CFP) |
|
| 1 | Yoshimatsu et al., 2016 | |
| Tg(opn1sw1:NTR-mCherry) |
|
| 1 | (8) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-266A5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73050 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85903 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173963 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:103666 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131319 (1) | 1760 nt | ||
| Genomic | GenBank:BX465210 (1) | 171708 nt | ||
| Polypeptide | UniProtKB:Q9W6A9 (1) | 336 aa |
- Cao, M., Xu, T., Song, Y., Wei, S., Wang, H., Guo, X., Yin, D. (2024) Brominated Flame Retardant HBCD and Artificial Light at Night Synergically Caused Visual Disorder and Sleep Difficulty in Zebrafish Larvae. Environmental science & technology. 58(39):17247-17258
- Hu, H., Qin, Y., Qu, Z., Huang, Y., Ren, X., Liu, M., Liu, F., Gao, P. (2024) The Zpr-3 Antibody Recognizes the 320-354 Region of Rho and Labels Both Rods and Green Cones in Zebrafish. Zebrafish. 21(6):394-400
- Neil, G.J., Kluttig, K.H., Allison, W.T. (2024) Determining Photoreceptor Cell Identity: Rod Versus Cone Fate Governed by tbx2b Opposing nrl. Investigative ophthalmology & visual science. 65:3939
- Shipman, A., Gao, Y., Liu, D., Sun, S., Zang, J., Sun, P., Syed, Z., Bhagavathi, A., Smith, E., Erickson, T., Hill, M., Neuhauss, S., Sui, S.F., Nicolson, T. (2024) Defects in exosome biogenesis are associated with sensorimotor defects in zebrafish vps4a mutants. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(50):
- Volkov, L.I., Ogawa, Y., Somjee, R., Vedder, H.E., Powell, H.E., Poria, D., Meiselman, S., Kefalov, V.J., Corbo, J.C. (2024) Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proceedings of the National Academy of Sciences of the United States of America. 121:e2402121121e2402121121
- Yang, H.Z., Zhuo, D., Huang, Z., Luo, G., Liang, S., Fan, Y., Zhao, Y., Lv, X., Qiu, C., Zhang, L., Liu, Y., Sun, T., Chen, X., Li, S.S., Jin, X. (2024) Deficiency of Acetyltransferase nat10 in Zebrafish Causes Developmental Defects in the Visual Function. Investigative ophthalmology & visual science. 65:3131
- Angueyra, J.M., Kunze, V.P., Patak, L.K., Kim, H., Kindt, K., Li, W. (2023) Transcription factors underlying photoreceptor diversity. eLIFE. 12:
- Brown-Panton, C.A., Sabour, S., Zoidl, G.S.O., Zoidl, C., Tabatabaei, N., Zoidl, G.R. (2023) Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish. Frontiers in cell and developmental biology. 11:11502731150273
- Kramer, A.C., Carthage, J., Berry, Y., Gurdziel, K., Cook, T.A., Thummel, R. (2023) A comparative analysis of gene and protein expression in chronic and acute models of photoreceptor degeneration in adult zebrafish. Frontiers in cell and developmental biology. 11:12332691233269
- Lu, K., Liang, X.F., Tang, S.L., Wu, J., Zhang, L., Wang, Y., Chai, F. (2023) Role of short-wave-sensitive 1 (sws1) in cone development and first feeding in larval zebrafish. Fish physiology and biochemistry. 49(5):801-813
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