Gene
mylpfa
- ID
- ZDB-GENE-990712-15
- Name
- myosin light chain, phosphorylatable, fast skeletal muscle a
- Symbol
- mylpfa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Involved in actin-myosin filament sliding and muscle tissue morphogenesis. Acts upstream of or within skeletal muscle tissue development. Predicted to be part of myosin complex. Predicted to be active in cytoplasm. Is expressed in caudal fin; esophagus; musculature system; segmental plate; and somite. Used to study distal arthrogryposis type 1A. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C. Orthologous to human MYL11 (myosin light chain 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 47 figures from 36 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb46 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Chong et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-mylpfa | Chong et al., 2020 | |
CRISPR2-mylpfa | Chong et al., 2020 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
distal arthrogryposis type 1C | Alliance | Arthrogryposis, distal, type 1C | 619110 |
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Human Disease | Fish | Conditions | Citations |
---|---|---|---|
distal arthrogryposis type 1A | mylpfaoz43/oz43 (AB) | standard conditions | Chong et al., 2020 |
distal arthrogryposis type 1A | mylpfaoz30/oz30 (AB) | standard conditions | Chong et al., 2020 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Myosin regulatory light chain |
---|---|---|---|---|---|---|
UniProtKB:O93409 | InterPro | 169 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
mylpfa-201
(1)
|
Ensembl | 1,471 nt | ||
mRNA |
mylpfa-202
(1)
|
Ensembl | 1,304 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(-1.9mylpfa:fsta,krt8:EGFP) |
|
| 1 | (2) | |
Tg(-1.9mylpfa:Cre-ERT2,cryaa:mCherry) |
|
| 1 | Mukherjee et al., 2018 | |
Tg(-1.9mylpfa:EGFP) |
|
| 1 | (4) | |
Tg(-2.2 mylpfa:GFP) |
|
| 1 | (14) | |
Tg(-2.5mylpfa:DsRed) |
|
| 1 | (4) | |
Tg(-2.5mylpfa:Eco.Epinecidin1-DsRed) |
|
| 1 | (4) | |
Tg2(mylpfa:EGFP) |
|
| 1 | Rezaei et al., 2019 | |
Tg2(mylpfa:GFP) |
|
| 1 | (3) | |
Tg2(mylpfa:mCherry) |
|
| 1 | (2) | |
Tg2(mylpfa:RFP) |
|
| 1 | (2) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-16L2 | ZFIN Curated Data | |
Encodes | EST | cb46 | (2) | |
Encodes | cDNA | MGC:56726 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191131 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131188 (1) | 1499 nt | ||
Genomic | GenBank:BX571714 (1) | 240105 nt | ||
Polypeptide | UniProtKB:O93409 (1) | 169 aa |
- Jia, H., Wu, R., Yang, H., Luo, K.Q. (2025) FRET-Based Sensor Zebrafish Reveal Muscle Cells Do Not Undergo Apoptosis in Starvation or Natural Aging-Induced Muscle Atrophy. Advanced science (Weinheim, Baden-Wurttemberg, Germany). :e2416811e2416811
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Pan, S.W., Wang, H.D., Hsiao, H.Y., Hsu, P.J., Tseng, Y.C., Liang, W.C., Jong, Y.J., Yuh, C.H. (2024) Creatine and L-carnitine attenuate muscular laminopathy in the LMNA mutation transgenic zebrafish. Scientific Reports. 14:1282612826
- Seda, M., Crespo, B., Corcelli, M., Osborn, D.P., Jenkins, D. (2023) A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis. Scientific Reports. 13:67836783
- Hsu, P.J., Wang, H.D., Tseng, Y.C., Pan, S.W., Sampurna, B.P., Jong, Y.J., Yuh, C.H. (2021) L-Carnitine ameliorates congenital myopathy in a tropomyosin 3 de novo mutation transgenic zebrafish. Journal of Biomedical Science. 28:8
- Hunter, M.V., Moncada, R., Weiss, J.M., Yanai, I., White, R.M. (2021) Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface. Nature communications. 12:6278
- Jin, X., Liu, W., Miao, J., Tai, Z., Li, L., Guan, P., Liu, J.X. (2021) Copper ions impair zebrafish skeletal myofibrillogenesis via epigenetic regulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35:e21686
- Lu, S., Lyu, Z., Wang, Z., Kou, Y., Liu, C., Li, S., Hu, M., Zhu, H., Wang, W., Zhang, C., Kuan, Y.S., Liu, Y.W., Chen, J., Tian, J. (2021) Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish. Theranostics. 11:2788-2805
- Spreafico, M., Cafora, M., Bragato, C., Capitanio, D., Marasca, F., Bodega, B., De Palma, C., Mora, M., Gelfi, C., Marozzi, A., Pistocchi, A. (2021) Targeting HDAC8 to ameliorate skeletal muscle differentiation in Duchenne muscular dystrophy. Pharmacological research. 170:105750
- Chong, J.X., Talbot, J.C., Teets, E.M., Previs, S., Martin, B.L., Shively, K.M., Marvin, C.T., Aylsworth, A.S., Saadeh-Haddad, R., Schatz, U.A., Inzana, F., Ben-Omran, T., Almusafri, F., Al-Mulla, M., Buckingham, K.J., Harel, T., Mor-Shaked, H., Radhakrishnan, P., Girisha, K.M., Nayak, S.S., Shukla, A., Dieterich, K., Faure, J., Rendu, J., Capri, Y., Latypova, X., Nickerson, D.A., Warshaw, D.M., Janssen, P.M.L., University of Washington Center for Mendelian Genomics., Amacher, S.L., Bamshad, M.J. (2020) Mutations in MYLPF Cause a Novel Segmental Amyoplasia that Manifests as Distal Arthrogryposis. American journal of human genetics. 107(2):293-310
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