Gene
mylpfa
- ID
- ZDB-GENE-990712-15
- Name
- myosin light chain, phosphorylatable, fast skeletal muscle a
- Symbol
- mylpfa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Involved in actin-myosin filament sliding and muscle tissue morphogenesis. Acts upstream of or within skeletal muscle tissue development. Predicted to be active in cytoplasm. Is expressed in caudal fin; esophagus; musculature system; segmental plate; and somite. Used to study distal arthrogryposis type 1A. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C. Orthologous to human MYL11 (myosin light chain 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 47 figures from 36 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb46 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Chong et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mylpfa | Chong et al., 2020 | |
| CRISPR2-mylpfa | Chong et al., 2020 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| distal arthrogryposis type 1C | Alliance | Arthrogryposis, distal, type 1C | 619110 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| distal arthrogryposis type 1A | mylpfaoz43/oz43 (AB) | standard conditions | Chong et al., 2020 |
| distal arthrogryposis type 1A | mylpfaoz30/oz30 (AB) | standard conditions | Chong et al., 2020 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Myosin regulatory light chain |
|---|---|---|---|---|---|---|
| UniProtKB:O93409 | InterPro | 169 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mylpfa-201
(1)
|
Ensembl | 1,471 nt | ||
| mRNA |
mylpfa-202
(1)
|
Ensembl | 1,304 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-1.9mylpfa:fsta,krt8:EGFP) |
|
| 1 | (2) | |
| Tg(-1.9mylpfa:Cre-ERT2,cryaa:mCherry) |
|
| 1 | Mukherjee et al., 2018 | |
| Tg(-1.9mylpfa:EGFP) |
|
| 1 | (4) | |
| Tg(-2.2 mylpfa:GFP) |
|
| 1 | (14) | |
| Tg(-2.5mylpfa:DsRed) |
|
| 1 | (4) | |
| Tg(-2.5mylpfa:Eco.Epinecidin1-DsRed) |
|
| 1 | (4) | |
| Tg2(mylpfa:EGFP) |
|
| 1 | Rezaei et al., 2019 | |
| Tg2(mylpfa:GFP) |
|
| 1 | (3) | |
| Tg2(mylpfa:mCherry) |
|
| 1 | (2) | |
| Tg2(mylpfa:RFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-16L2 | ZFIN Curated Data | |
| Encodes | EST | cb46 | (2) | |
| Encodes | cDNA | MGC:56726 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191131 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131188 (1) | 1499 nt | ||
| Genomic | GenBank:BX571714 (1) | 240105 nt | ||
| Polypeptide | UniProtKB:O93409 (1) | 169 aa |
- Akiyama, C., Sakata, S., Ono, F. (2025) Normal locomotion in zebrafish lacking the sodium channel NaV1.4 suggests that the need for muscle action potentials is not universal. PLoS Biology. 23:e3003137e3003137
- Jia, H., Wu, R., Yang, H., Luo, K.Q. (2025) FRET-Based Sensor Zebrafish Reveal Muscle Cells Do Not Undergo Apoptosis in Starvation or Natural Aging-Induced Muscle Atrophy. Advanced science (Weinheim, Baden-Wurttemberg, Germany). :e2416811e2416811
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Pan, S.W., Wang, H.D., Hsiao, H.Y., Hsu, P.J., Tseng, Y.C., Liang, W.C., Jong, Y.J., Yuh, C.H. (2024) Creatine and L-carnitine attenuate muscular laminopathy in the LMNA mutation transgenic zebrafish. Scientific Reports. 14:1282612826
- Seda, M., Crespo, B., Corcelli, M., Osborn, D.P., Jenkins, D. (2023) A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis. Scientific Reports. 13:67836783
- Hsu, P.J., Wang, H.D., Tseng, Y.C., Pan, S.W., Sampurna, B.P., Jong, Y.J., Yuh, C.H. (2021) L-Carnitine ameliorates congenital myopathy in a tropomyosin 3 de novo mutation transgenic zebrafish. Journal of Biomedical Science. 28:8
- Hunter, M.V., Moncada, R., Weiss, J.M., Yanai, I., White, R.M. (2021) Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface. Nature communications. 12:6278
- Jin, X., Liu, W., Miao, J., Tai, Z., Li, L., Guan, P., Liu, J.X. (2021) Copper ions impair zebrafish skeletal myofibrillogenesis via epigenetic regulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35:e21686
- Lu, S., Lyu, Z., Wang, Z., Kou, Y., Liu, C., Li, S., Hu, M., Zhu, H., Wang, W., Zhang, C., Kuan, Y.S., Liu, Y.W., Chen, J., Tian, J. (2021) Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish. Theranostics. 11:2788-2805
- Spreafico, M., Cafora, M., Bragato, C., Capitanio, D., Marasca, F., Bodega, B., De Palma, C., Mora, M., Gelfi, C., Marozzi, A., Pistocchi, A. (2021) Targeting HDAC8 to ameliorate skeletal muscle differentiation in Duchenne muscular dystrophy. Pharmacological research. 170:105750
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