Gene
fsta
- ID
- ZDB-GENE-990714-11
- Name
- follistatin a
- Symbol
- fsta Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable activin binding activity. Acts upstream of or within determination of dorsal identity; embryonic organ morphogenesis; and midbrain development. Predicted to be active in extracellular space. Is expressed in several structures, including immature eye; mesoderm; nervous system; neural rod; and neural tube. Human ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to human FST (follistatin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 51 figures from 35 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb446 (47 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fsta | Askary et al., 2017 | |
| CRISPR2-fsta | Zebrafish Nomenclature Committee | |
| CRISPR3-fsta | Zebrafish Nomenclature Committee | |
| MO1-fsta | N/A | (2) |
| MO2-fsta | N/A | Dal-Pra et al., 2006 |
| MO3-fsta | N/A | Tsukada et al., 2010 |
| MO4-fsta | N/A | Tsukada et al., 2010 |
| MO5-fsta | N/A | (2) |
| MO6-fsta | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Follistatin-like, N-terminal | Follistatin/Osteonectin EGF domain | Kazal domain | Kazal domain superfamily | TB domain | TGF-beta binding (TB) domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AZS1 | InterPro | 327 | ||||||
| UniProtKB:Q9YHV4 | InterPro | 322 | ||||||
| UniProtKB:A0A8M2BCI8 | InterPro | 349 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-111K10 | ZFIN Curated Data | |
| Encodes | EST | cb446 | Thisse et al., 2001 | |
| Encodes | EST | fd07h10 | ||
| Encodes | cDNA | MGC:100822 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173526 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131037 (1) | 3529 nt | ||
| Genomic | GenBank:BX537294 (1) | 204048 nt | ||
| Polypeptide | UniProtKB:A0A8M2BCI8 (1) | 349 aa |
- Bulk, J., Kyrychenko, V., Rensinghoff, P.M., Ghaderi Ardekani, Z., Heermann, S. (2023) Holoprosencephaly with a Special Form of Anophthalmia Result from Experimental Induction of bmp4, Oversaturating BMP Antagonists in Zebrafish. International Journal of Molecular Sciences. 24(9):
- Lau, E.S., Zhu, B., Sun, M.A., Ngai, S.M., Ge, W. (2023) Proteomic analysis of zebrafish Folliculogenesis identifies YB-1 (Ybx1/ybx1) as a potential gatekeeping molecule controlling early ovarian Folliculogenesis. Biology of reproduction. 109(4):482-497
- Zhai, Y., Zhang, X., Zhao, C., Geng, R., Wu, K., Yuan, M., Ai, N., Ge, W. (2023) Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis. PLoS Genetics. 19:e1010954e1010954
- Chang, N.C., Rovira, Q., Wells, J.N., Feschotte, C., Vaquerizas, J.M. (2022) Zebrafish transposable elements show extensive diversification in age, genomic distribution, and developmental expression. Genome research. 32(7):1408-1423
- Li, R.F., Wang, Y.S., Lu, F.I., Huang, Y.S., Chiu, C.C., Tai, M.H., Wu, C.Y. (2022) Identification of Novel Vascular Genes Downstream of Islet2 and Nr2f1b Transcription Factors. Biomedicines. 10(6)
- Zhao, C., Zhai, Y., Geng, R., Wu, K., Song, W., Ai, N., Ge, W. (2022) Genetic analysis of activin/inhibin β subunits in zebrafish development and reproduction. PLoS Genetics. 18:e1010523e1010523
- Knickmeyer, M.D., Mateo, J.L., Heermann, S. (2021) BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish. International Journal of Molecular Sciences. 22(9):
- Demirci, Y., Cucun, G., Poyraz, Y.K., Mohammed, S., Heger, G., Papatheodorou, I., Ozhan, G. (2020) Comparative Transcriptome Analysis of the Regenerating Zebrafish Telencephalon Unravels a Resource With Key Pathways During Two Early Stages and Activation of Wnt/β-Catenin Signaling at the Early Wound Healing Stage. Frontiers in cell and developmental biology. 8:584604
- He, B.L., Yang, N., Man, C.H., Ng, N.K., Cher, C.Y., Leung, H.C., Kan, L.L., Cheng, B.Y., Lam, S.S., Wang, M.L., Zhang, C.X., Kwok, H., Cheng, G., Sharma, R., Ma, A.C., So, C.E., Kwong, Y.L., Leung, A.Y. (2020) Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia. EMBO Molecular Medicine. 12(4):e10895
- Lu, H., Zhao, C., Zhu, B., Zhang, Z., Ge, W. (2020) Loss of Inhibin Advances Follicle Activation and Female Puberty Onset but Blocks Oocyte Maturation in Zebrafish. Endocrinology. 161(12):
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