Gene

gata4

ID
ZDB-GENE-980526-476
Name
GATA binding protein 4
Symbol
gata4 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cardiac muscle tissue regeneration; heart morphogenesis; and swim bladder formation. Predicted to be active in nucleus. Is expressed in several structures, including endocrine system; gut; liver and biliary system; mesoderm; and pericardial region. Human ortholog(s) of this gene implicated in congenital heart disease (multiple). Orthologous to human GATA4 (GATA binding protein 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
91 figures from 72 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
fh320Allele with one point mutationUnknownUnknownENU
fh321Allele with one point mutationUnknownUnknownENU
gata4_unrecoveredAllele with one point mutationUnknownUnknownENU
sa44950Allele with one point mutationUnknownUnknownENU
sa45720Allele with one point mutationUnknownPremature StopENU
wcm5Allele with one deletionUnknownUnknownTALEN
wcm6Allele with one delinsUnknownUnknownTALEN
1 - 7 of 7
Show
Sequence Targeting Reagents
1 - 8 of 8
Show
Human Disease
Associated With gata4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
atrial heart septal defect 2 Alliance Atrial septal defect 2 607941
atrioventricular septal defect Alliance Atrioventricular septal defect 4 614430
tetralogy of Fallot Alliance Tetralogy of Fallot 187500
ventricular septal defect Alliance Ventricular septal defect 1 614429
?Testicular anomalies with or without congenital heart disease 615542
1 - 5 of 5
Associated With gata4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000679 Zinc finger, GATA-type
Domain IPR008013 GATA-type transcription activator, N-terminal
Family IPR016375 Transcription factor GATA-4/5/6
Family IPR039355 Transcription factor GATA
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
1 - 5 of 5
Domain Details Per Protein
Protein Additional Resources Length GATA-type transcription activator, N-terminal Transcription factor GATA Transcription factor GATA-4/5/6 Zinc finger, GATA-type Zinc finger, NHR/GATA-type
UniProtKB:Q09JY7 InterPro 352
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 20
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA gata4-201 (1) Ensembl 1,214 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(-7.8gata4:GFP)
  • gata4
  • Danio rerio
1 (5)
Tg(-11gata4:GFP)
  • gata4
  • Danio rerio
1 (3)
Tg(-14.8gata4:ERT2-Cre-ERT2)
  • gata4
  • Danio rerio
1 (5)
Tg(-14.8gata4:GFP)
  • gata4
  • Danio rerio
2 (30)
Tg(actb2:LOXP-TagBFP-LOXP-mCherry,dngata4)
  • Danio rerio
1 (4)
Tg(actb2:LOXP-TagBFP-LOXP-STOP-LOXP-gata4)
  • Danio rerio
1 (4)
Tg(gata4:DsRed2)
  • gata4
  • Danio rerio
1 (4)
Tg(hsp70l:Mmu.Mxi1-gata4,myl7:EGFP)
  • Danio rerio
  • Mus musculus
1 (3)
1 - 8 of 8
Show
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-107C13ZFIN Curated Data
1 - 1 of 1
Show
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanGATA48
Amino acid sequence comparison (5)
Phylogenetic tree (1)
Conserved genome location (synteny) (2)
MouseGata414
Phylogenetic tree (1)
Amino acid sequence comparison (5)
Conserved genome location (synteny) (1)
Citations
1 - 10 of 187
Show