Gene
gata4
- ID
- ZDB-GENE-980526-476
- Name
- GATA binding protein 4
- Symbol
- gata4 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cardiac muscle tissue regeneration; heart morphogenesis; and swim bladder formation. Predicted to be active in nucleus. Is expressed in several structures, including endocrine system; gut; liver and biliary system; mesoderm; and pericardial region. Human ortholog(s) of this gene implicated in congenital heart disease (multiple). Orthologous to human GATA4 (GATA binding protein 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 91 figures from 72 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
fh320 | Allele with one point mutation | Unknown | Unknown | ENU | |
fh321 | Allele with one point mutation | Unknown | Unknown | ENU | |
gata4_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU | |
sa44950 | Allele with one point mutation | Unknown | Unknown | ENU | |
sa45720 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
wcm5 | Allele with one deletion | Unknown | Unknown | TALEN | |
wcm6 | Allele with one delins | Unknown | Unknown | TALEN |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-gata4 | (2) | |
CRISPR2-gata4 | Shi et al., 2025 | |
MO1-gata4 | N/A | (11) |
MO2-gata4 | N/A | (3) |
MO3-gata4 | N/A | Peterkin et al., 2007 |
MO4-gata4 | N/A | Lin et al., 2009 |
MO5-gata4 | N/A | Park et al., 2009 |
TALEN1-gata4 | (2) |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
atrial heart septal defect 2 | Alliance | Atrial septal defect 2 | 607941 |
atrioventricular septal defect | Alliance | Atrioventricular septal defect 4 | 614430 |
tetralogy of Fallot | Alliance | Tetralogy of Fallot | 187500 |
ventricular septal defect | Alliance | Ventricular septal defect 1 | 614429 |
?Testicular anomalies with or without congenital heart disease | 615542 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | GATA-type transcription activator, N-terminal | Transcription factor GATA | Transcription factor GATA-4/5/6 | Zinc finger, GATA-type | Zinc finger, NHR/GATA-type |
---|---|---|---|---|---|---|---|
UniProtKB:Q09JY7 | InterPro | 352 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(-7.8gata4:GFP) |
|
| 1 | (5) | |
Tg(-11gata4:GFP) |
|
| 1 | (3) | |
Tg(-14.8gata4:ERT2-Cre-ERT2) |
|
| 1 | (5) | |
Tg(-14.8gata4:GFP) |
|
| 2 | (30) | |
Tg(actb2:LOXP-TagBFP-LOXP-mCherry,dngata4) |
| 1 | (4) | ||
Tg(actb2:LOXP-TagBFP-LOXP-STOP-LOXP-gata4) |
| 1 | (4) | ||
Tg(gata4:DsRed2) |
|
| 1 | (4) | |
Tg(hsp70l:Mmu.Mxi1-gata4,myl7:EGFP) |
|
| 1 | (3) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-107C13 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131236 (1) | 1142 nt | ||
Genomic | GenBank:CU207296 (2) | 98771 nt | ||
Polypeptide | UniProtKB:Q09JY7 (1) | 352 aa |
- Deebani, A., Mary, J., Dhinoja, S., Al Qaryoute, A., Fallatah, W., Jagadeeswaran, P. (2025) Knockdown of zebrafish tmem242 enhances the production of ROS that signals to increase f9a expression resulting in DIC-like condition. Scientific Reports. 15:30583058
- Prill, K., Windsor Reid, P., Pilgrim, D. (2025) Heart Morphogenesis Requires Smyd1b for Proper Incorporation of the Second Heart Field in Zebrafish. Genes. 16:
- Shi, W., Yi, X., Ruan, H., Wang, D., Wu, D., Jiang, P., Luo, L., Ma, X., Jiang, F., Li, C., Wu, W., Luo, L., Li, L., Wang, G., Qiu, J., Huang, H. (2025) An animal model recapitulates human hepatic diseases associated with GATA6 mutations. Proceedings of the National Academy of Sciences of the United States of America. 122:e2317801121e2317801121
- Guo, J., Lin, K., Wang, S., He, X., Huang, Z., Zheng, M. (2024) Effects and mechanisms of Porphyromonas gingivalis outer membrane vesicles induced cardiovascular injury. BMC oral health. 24:112112
- Wang, A., Wan, X., Zhu, F., Liu, H., Song, X., Huang, Y., Zhu, L., Ao, Y., Zeng, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Li, H., Zhuang, P., Jiao, J., Zhang, Y. (2024) Habitual Daily Intake of Fried Foods Raises Transgenerational Inheritance Risk of Heart Failure Through NOTCH1-Triggered Apoptosis. Research (Washington, D.C.). 7:04010401
- Yu, C., Li, X., Ma, J., Liang, S., Zhao, Y., Li, Q., Zhang, R. (2024) Spatiotemporal modulation of nitric oxide and Notch signaling by hemodynamic-responsive Trpv4 is essential for ventricle regeneration. Cellular and molecular life sciences : CMLS. 81:6060
- Zhao, Y., Lv, H., Yu, C., Liang, J., Yu, H., Du, Z., Zhang, R. (2024) Systemic inhibition of mitochondrial fatty acid β-oxidation impedes zebrafish ventricle regeneration. Biochimica et biophysica acta. Molecular basis of disease. 1870(7):167442
- Friedman, C.E., Cheetham, S.W., Negi, S., Mills, R.J., Ogawa, M., Redd, M.A., Chiu, H.S., Shen, S., Sun, Y., Mizikovsky, D., Bouveret, R., Chen, X., Voges, H.K., Paterson, S., De Angelis, J.E., Andersen, S.B., Cao, Y., Wu, Y., Jafrani, Y.M.A., Yoon, S., Faulkner, G.J., Smith, K.A., Porrello, E., Harvey, R.P., Hogan, B.M., Nguyen, Q., Zeng, J., Kikuchi, K., Hudson, J.E., Palpant, N.J. (2023) HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function. Developmental Cell. 59(1):91-107.e6
- Huang, L., Han, F., Huang, Y., Liu, J., Liao, X., Cao, Z., Li, W. (2023) Sphk1 deficiency induces apoptosis and developmental defects and premature death in zebrafish. Fish physiology and biochemistry. 49(4):737-750
- Jin, Q., Hu, Y., Gao, Y., Zheng, J., Chen, J., Gao, C., Peng, J. (2023) Hhex and Prox1a synergistically dictate the hepatoblast to hepatocyte differentiation in zebrafish. Biochemical and Biophysical Research Communications. 686:149182149182
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