Gene
lmo2
- ID
- ZDB-GENE-980526-419
- Name
- LIM domain only 2 (rhombotin-like 1)
- Symbol
- lmo2 Nomenclature History
- Previous Names
-
- ttg2 (1)
- wu:fc83a08
- zgc:111930
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor binding activity and transcription coactivator activity. Predicted to contribute to DNA binding activity. Involved in hemopoiesis. Acts upstream of or within several processes, including fin regeneration; hemopoiesis; and retinal blood vessel morphogenesis. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including hematopoietic cell; hematopoietic system; mesoderm; renal system; and vasculature. Orthologous to human LMO2 (LIM domain only 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 121 figures from 91 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns499 | Allele with one delins | Exon 3 | Unknown | CRISPR | |
| bns500 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| pku684ld | Allele with one deletion | Enhancer | Unknown | not specified | |
| vu270 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf3558 | Allele with one insertion | Exon 2 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-lmo2 | Matrone et al., 2021 | |
| CRISPR2-lmo2 | Winter et al., 2022 | |
| CRISPR3-lmo2 | Winter et al., 2022 | |
| CRISPR4-lmo2 | Winter et al., 2022 | |
| CRISPR5-lmo2 | Mattonet et al., 2022 | |
| MO1-lmo2 | N/A | (2) |
| MO2-lmo2 | N/A | (4) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Leukemia, acute T-cell | 180385 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | LMO/RBTN Transcription Factors | Zinc finger, LIM-type |
|---|---|---|---|---|
| UniProtKB:Q9PTJ3 | InterPro | 159 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg2(lmo2:LOXP-DsRed-LOXP-EGFP) |
|
| 1 | Shu et al., 2015 | |
| Tg(lmo2:Cre) |
|
| 1 | (6) | |
| Tg(lmo2:DsRed) |
|
| 1 | (21) | |
| Tg(lmo2:EGFP) |
|
| 2 | (14) | |
| Tg(lmo2:LOXP-DsRed-LOXP-bmi1-EGFP) |
|
| 1 | (3) | |
| Tg(lmo2:LOXP-DsRed-LOXP-EGFP) |
|
| 1 | (10) | |
| Tg(lmo2:LOXP-DsRed-LOXP-EGFP-dncebpa) |
|
| 1 | (3) | |
| Tg(lmo2:LOXP-DsRed-LOXP-hoxb4a-EGFP) |
|
| 1 | Shu et al., 2015 | |
| Tg(lmo2:mir30e-actb1-DsRed) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-110E4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-10O6 | ZFIN Curated Data | |
| Encodes | EST | fc83a08 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:111930 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131111 (1) | 1805 nt | ||
| Genomic | GenBank:CT025900 (1) | 126992 nt | ||
| Polypeptide | UniProtKB:Q9PTJ3 (1) | 159 aa |
- Liu, M., Li, Y., Deng, Z., Zhang, K., Huang, S., Xia, J., Feng, Y., Liang, Y., Sun, C., Liu, X., Li, S., Su, B., Dong, Y., Huang, S. (2025) Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage. Cell Death & Disease. 16:8484
- Martínez-López, M.F., de Almeida, C.R., Fontes, M., Mendes, R.V., Kaufmann, S.H.E., Fior, R. (2024) Macrophages directly kill bladder cancer cells through TNF signaling as an early response to BCG therapy. Disease models & mechanisms. 17(8):
- Edwards, H.E., Edgington, M.J., Souder, J.P., Gorelick, D.A. (2023) Hemato-vascular specification requires arnt1 and arnt2 genes in zebrafish embryos. Development (Cambridge, England). 150(9)
- Gafranek, J.T., D'Aniello, E., Ravisankar, P., Thakkar, K., Vagnozzi, R.J., Lim, H.W., Salomonis, N., Waxman, J.S. (2023) Sinus venosus adaptation models prolonged cardiovascular disease and reveals insights into evolutionary transitions of the vertebrate heart. Nature communications. 14:55095509
- Liang, F., Lu, X., Wu, B., Yang, Y., Qin, W. (2023) Nucleolar Protein 56 Deficiency in Zebrafish Leads to Developmental Abnormalities and Anemia via p53 and JAK2-STAT3 Signaling. Biology. 12(4):
- Liu, W., Lin, S., Li, L., Tai, Z., Liu, J.X. (2023) Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance. Cell regeneration (London, England). 12:1010
- Suzuki, H., Ogawa, T., Fujita, S., Sone, R., Kawahara, A. (2023) Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis. Scientific Reports. 13:1227912279
- Tamaoki, J., Maeda, H., Kobayashi, I., Takeuchi, M., Ohashi, K., Gore, A., Bonkhofer, F., Patient, R., Weinstein, B.M., Kobayashi, M. (2023) LSD1 promotes the egress of hematopoietic stem and progenitor cells into the bloodstream during the endothelial-to-hematopoietic transition. Developmental Biology. 501:92-103
- Wu, J., Li, J., Chen, K., Liu, G., Zhou, Y., Chen, W., Zhu, X., Ni, T.T., Zhang, B., Jin, D., Li, D., Kang, L., Wu, Y., Zhu, P., Xie, P., Zhong, T.P. (2023) Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation. Proceedings of the National Academy of Sciences of the United States of America. 120:e2209062120e2209062120
- Basheer, F., Lee, E., Liongue, C., Ward, A.C. (2022) Zebrafish Model of Severe Combined Immunodeficiency (SCID) Due to JAK3 Mutation. Biomolecules. 12(10):
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