Gene
actb1
- ID
- ZDB-GENE-000329-1
- Name
- actin, beta 1
- Symbol
- actb1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Predicted to be located in several cellular components, including cytoskeleton; dense body; and focal adhesion. Predicted to be active in actin filament. Is expressed in several structures, including eye; hematopoietic cell; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; autosomal dominant nonsyndromic deafness 20; and thrombocytopenia. Orthologous to several human genes including ACTB (actin beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 36 figures from 33 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55989 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013756Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la013757Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la013758Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028200Tg | Transgenic insertion | Unknown | Unknown | DNA |
1 - 4 of 4
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-actb1 | Parvez et al., 2021 | |
| CRISPR2-actb1 | Parvez et al., 2021 | |
| CRISPR3-actb1 | Sun et al., 2019 | |
| CRISPR4-actb1 | Sun et al., 2019 | |
| CRISPR5-actb1 | Sun et al., 2019 |
1 - 5 of 5
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Baraitser-Winter syndrome 1 | Alliance | Baraitser-Winter syndrome 1 | 243310 |
| Becker nevus, syndromic or isolated, somatic mosaic | 604919 | ||
| Congenital smooth muscle hamartoma with or without hemihypertrophy, somatic mosaic | 620470 | ||
| Dystonia-deafness syndrome 1 | 607371 | ||
| Thrombocytopenia 8, with dysmorphic features and developmental delay | 620475 |
1 - 5 of 5
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Actin/actin-like conserved site | Actin, conserved site | Actin family | ATPase, nucleotide binding domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q7ZVI7 | InterPro | 375 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(actb1:EGFP) |
|
| 1 | (4) | |
| Tg(-2.2actb1:gh1,-2.2actb1:GFP) |
|
| 1 | (3) | |
| Tg(-2.2actb1:smtla,-2.2actb1:GFP) |
|
| 1 | (3) | |
| Tg(-2.2actb1:smtlb,-2.2actb1:GFP) |
|
| 1 | (3) | |
| Tg(-2.5actb1:RTTA-2A-ZsGreen,TETRE:mxd3-2A-mCherry) |
|
| 3 | Tsai et al., 2021 | |
| Tg(-2.5actb1:TETA-atf4a-2A-mCherry) |
|
| 2 | Yeh et al., 2017 | |
| Tg(-2.7actb1:EGFP) |
|
| 1 | (4) | |
| Tg(actb1:Bta.Ltf-GFP) |
|
| 6 | (5) | |
| Tg(actb1:Cas9-2A-GFP) |
|
| 1 | Lai et al., 2022 | |
| Tg(actb1:EGFP-Hsa.HRAS) |
|
| 1 | (3) |
1 - 10 of 39
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-160D14 | ZFIN Curated Data | |
| Encodes | EST | fd18f05 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55989 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77623 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192419 | ZFIN Curated Data |
1 - 5 of 5
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131031 (1) | 1730 nt | ||
| Genomic | GenBank:BX649405 (1) | 231915 nt | ||
| Polypeptide | UniProtKB:Q7ZVI7 (1) | 375 aa |
- Sebo, D.J., Ali, I., Fetsko, A.R., Trimbach, A.A., Taylor, M.R. (2025) Activation of Wnt/β-catenin in neural progenitor cells regulates blood-brain barrier development and promotes neuroinflammation. Scientific Reports. 15:34963496
- She, P., Gao, B., Li, D., Wu, C., Zhu, X., He, Y., Mo, F., Qi, Y., Jin, D., Chen, Y., Zhao, X., Lin, J., Hu, H., Li, J., Zhang, B., Xie, P., Lin, C., Christoffels, V.M., Wu, Y., Zhu, P., Zhong, T.P. (2025) The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis. Nature communications. 16:232232
- Shi, W., Yi, X., Ruan, H., Wang, D., Wu, D., Jiang, P., Luo, L., Ma, X., Jiang, F., Li, C., Wu, W., Luo, L., Li, L., Wang, G., Qiu, J., Huang, H. (2025) An animal model recapitulates human hepatic diseases associated with GATA6 mutations. Proceedings of the National Academy of Sciences of the United States of America. 122:e2317801121e2317801121
- Valderrama, B., Daly, I., Gunnigle, E., O'Riordan, K.J., Chichlowski, M., Banerjee, S., Skowronski, A.A., Pandey, N., Cryan, J.F., Clarke, G., Nagpal, J. (2025) From in silico screening to in vivo validation in zebrafish - a framework for reeling in the right psychobiotics. Food & function. :
- Vaz-Rodrigues, R., Mazuecos, L., Contreras, M., González-García, A., Rafael, M., Villar, M., de la Fuente, J. (2025) Tick salivary proteins metalloprotease and allergen-like p23 are associated with response to glycan α-Gal and mycobacterium infection. Scientific Reports. 15:88498849
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Zhang, H.Y., Li, K.Y., Wang, Y.L., Wei, C.J., Gao, Y.X., Ren-Zhou, ., Zhong, Y.B., Yin, Z.J., Ren, D.L. (2025) ROS regulates circadian rhythms by modulating Ezh2 interactions with clock proteins. Redox Biology. 81:103526103526
- Angom, R.S., Joshi, A., Patowary, A., Sivadas, A., Ramasamy, S., K V, S., Kaushik, K., Sabharwal, A., Lalwani, M.K., K, S., Singh, N., Scaria, V., Sivasubbu, S. (2024) Forward genetic screen using a gene-breaking trap approach identifies a novel role of grin2bb-associated RNA transcript (grin2bbART) in zebrafish heart function. Frontiers in cell and developmental biology. 12:13392921339292
- Dasgupta, A., Reagor, C.C., Paik, S.P., Snow, L.M., Jacobo, A., Hudspeth, A.J. (2024) Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish. eLIFE. 12:
- Han, X., He, W., Liang, D., Liu, X., Zhou, J., de Thé, H., Zhu, J., Yuan, H. (2024) Creg1 Regulates Erythroid Development via TGF-β/Smad2-Klf1 Axis in Zebrafish. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 11(33):e2402804
1 - 10 of 401
Show