Gene

actb1

ID
ZDB-GENE-000329-1
Name
actin, beta 1
Symbol
actb1 Nomenclature History
Previous Names
  • bact
  • actine (1)
  • B-ACTZF
  • bactin1 (1)
  • wu:fd18f05 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Predicted to be located in several cellular components, including cytoskeleton; dense body; and focal adhesion. Predicted to be active in actin filament. Is expressed in several structures, including eye; hematopoietic cell; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; autosomal dominant nonsyndromic deafness 20; and thrombocytopenia. Orthologous to several human genes including ACTB (actin beta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
36 figures from 33 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la013756TgTransgenic insertionUnknownUnknownDNA
la013757TgTransgenic insertionUnknownUnknownDNA
la013758TgTransgenic insertionUnknownUnknownDNA
la028200TgTransgenic insertionUnknownUnknownDNA
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Sequence Targeting Reagents
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Human Disease
Associated With actb1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Baraitser-Winter syndrome 1 Alliance Baraitser-Winter syndrome 1 243310
Becker nevus, syndromic or isolated, somatic mosaic 604919
Congenital smooth muscle hamartoma with or without hemihypertrophy, somatic mosaic 620470
Dystonia-deafness syndrome 1 607371
Thrombocytopenia 8, with dysmorphic features and developmental delay 620475
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Associated With actb1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR004001 Actin, conserved site
Conserved_site IPR020902 Actin/actin-like conserved site
Family IPR004000 Actin family
Homologous_superfamily IPR043129 ATPase, nucleotide binding domain
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Domain Details Per Protein
Protein Additional Resources Length Actin/actin-like conserved site Actin, conserved site Actin family ATPase, nucleotide binding domain
UniProtKB:Q7ZVI7 InterPro 375
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 1
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA actb1-201 (1) Ensembl 1,788 nt
mRNA actb1-202 (1) Ensembl 1,019 nt
mRNA actb1-204 (1) Ensembl 796 nt
mRNA actb1-205 (1) Ensembl 924 nt
mRNA actb1-207 (1) Ensembl 1,215 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-actb1 polyclonal Rabbit
  • IHC
  • WB
AnaSpec
3
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Plasmids
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(actb1:EGFP)
  • actb1
  • Danio rerio
1 (4)
Tg(-2.2actb1:gh1,-2.2actb1:GFP)
  • actb1
  • Danio rerio
1 (3)
Tg(-2.2actb1:smtla,-2.2actb1:GFP)
  • actb1
  • Danio rerio
1 (3)
Tg(-2.2actb1:smtlb,-2.2actb1:GFP)
  • actb1
  • Danio rerio
1 (3)
Tg(-2.5actb1:RTTA-2A-ZsGreen,TETRE:mxd3-2A-mCherry)
  • Danio rerio
3Tsai et al., 2021
Tg(-2.5actb1:TETA-atf4a-2A-mCherry)
  • actb1
  • Danio rerio
2Yeh et al., 2017
Tg(-2.7actb1:EGFP)
  • actb1
  • Danio rerio
1 (4)
Tg(actb1:Bta.Ltf-GFP)
  • actb1
  • Bos taurus
  • Danio rerio
6 (5)
Tg(actb1:Cas9-2A-GFP)
  • actb1
  • Danio rerio
1Lai et al., 2022
Tg(actb1:EGFP-Hsa.HRAS)
  • actb1
  • Danio rerio
  • Homo sapiens
1 (3)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-160D14ZFIN Curated Data
EncodesESTfd18f05ZFIN Curated Data
EncodescDNAMGC:55989ZFIN Curated Data
EncodescDNAMGC:77623ZFIN Curated Data
EncodescDNAMGC:192419ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanACTB7
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseActb5
Conserved genome location (synteny) (1)
Citations
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