Gene
bmi1a
- ID
- ZDB-GENE-030131-224
- Name
- bmi1 polycomb ring finger oncogene 1a
- Symbol
- bmi1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable promoter-specific chromatin binding activity. Acts upstream of or within cerebellum development; hematopoietic stem cell migration; and primitive hemopoiesis. Predicted to be located in nucleus. Predicted to be part of PRC1 complex. Is expressed in eye; gonad; and midbrain hindbrain boundary. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; hepatocellular carcinoma; and renal Wilms' tumor. Orthologous to several human genes including BMI1 (BMI1 proto-oncogene, polycomb ring finger).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56403 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-bmi1a | N/A | Zhou et al., 2011 |
| MO2-bmi1a | N/A | (2) |
| TALEN1-bmi1a | Moore et al., 2012 |
1 - 3 of 3
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | RAWUL domain | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site |
|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4I9F7 | InterPro | 322 | ||||
| UniProtKB:Q8JIR0 | InterPro | 320 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-14G13 | ZFIN Curated Data | |
| Encodes | EST | fb17g03 | ||
| Encodes | EST | fd18f06 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56403 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_194366 (1) | 2215 nt | ||
| Genomic | GenBank:CR376737 (2) | 158366 nt | ||
| Polypeptide | UniProtKB:A0A0R4I9F7 (1) | 322 aa |
- Fang, X., Xu, S., Zhang, Y., Xu, J., Huang, Z., Liu, W., Wang, S., Yen, K., Zhang, W. (2021) Asxl1 C-terminal mutation perturbs neutrophil differentiation in zebrafish. Leukemia. 35(8):2299-2310
- Raby, L., Völkel, P., Hasanpour, S., Cicero, J., Toillon, R.A., Adriaenssens, E., Van Seuningen, I., Le Bourhis, X., Angrand, P.O. (2021) Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish. Cells. 10(11):
- Chrispijn, N.D., Andralojc, K.M., Castenmiller, C., Kamminga, L.M. (2018) Gene expression profile of a selection of Polycomb Group genes during zebrafish embryonic and germ line development. PLoS One. 13:e0200316
- England, S.J., Campbell, P.C., Banerjee, S., Swanson, A.J., Lewis, K.E. (2017) Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes.. Frontiers in cell and developmental biology. 5:5
- Lobbardi, R., Pinder, J., Martinez-Pastor, B., Theodorou, M., Blackburn, J.S., Abraham, B.J., Namiki, Y., Mansour, M., Abdelfattah, N.S., Molodtsov, A., Alexe, G., Toiber, D., de Waard, M., Jain, E., Boukhali, M., Lion, M., Bhere, D., Shah, K., Gutierrez, A., Stegmaier, K., Silverman, L.B., Sadreyev, R.I., Asara, J.M., Oettinger, M.A., Haas, W., Look, A.T., Young, R.A., Mostoslavsky, R., Dellaire, G., Langenau, D.M. (2017) TOX regulates growth, DNA repair, and genomic instability in T-cell Acute Lymphoblastic Leukemia. Cancer discovery. 7(11):1336-1353
- Dupret, B., Völkel, P., Le Bourhis, X., Angrand, P.O. (2016) The Polycomb Group Protein Pcgf1 Is Dispensable in Zebrafish but Involved in Early Growth and Aging. PLoS One. 11:e0158700
- Moore, F.E., Garcia, E.G., Lobbardi, R., Jain, E., Tang, Q., Moore, J.C., Cortes, M., Molodtsov, A., Kasheta, M., Luo, C.C., Garcia, A.J., Mylvaganam, R., Yoder, J.A., Blackburn, J.S., Sadreyev, R.I., Ceol, C.J., North, T.E., Langenau, D.M. (2016) Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish. The Journal of experimental medicine. 213(6):979-92
- Ray, M.K., Wiskow, O., King, M.J., Ismail, N., Ergun, A., Wang, Y., Plys, A.J., Davis, C.P., Kathrein, K., Sadreyev, R., Borowsky, M.L., Eggan, K., Zon, L., Galloway, J.L., Kingston, R.E. (2016) CAT7 and cat7l long non-coding RNAs Tune Polycomb Repressive Complex 1 Function During Human and Zebrafish Development. The Journal of biological chemistry. 291(37):19558-72
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Mochida, G.H., Ganesh, V.S., de Michelena, M.I., Dias, H., Atabay, K.D., Kathrein, K.L., Huang, H.T., Hill, R.S., Felie, J.M., Rakiec, D., Gleason, D., Hill, A.D., Malik, A.N., Barry, B.J., Partlow, J.N., Tan, W.H., Glader, L.J., Barkovich, A.J., Dobyns, W.B., Zon, L.I., and Walsh, C.A. (2012) CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development. Nature Genetics. 44(11):1260-1264
1 - 10 of 18
Show