Gene
cdx4
- ID
- ZDB-GENE-980526-330
- Name
- caudal type homeobox 4
- Symbol
- cdx4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables DNA binding activity and chromatin binding activity. Acts upstream of or within several processes, including anterior/posterior pattern specification; embryonic foregut morphogenesis; and post-anal tail morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; endoderm; germ ring; mesoderm; and presumptive mesoderm. Orthologous to human CDX4 (caudal type homeobox 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 77 figures from 46 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb546 (24 images)
Wild Type Expression Summary
- All Phenotype Data
- 31 figures from 17 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ch107 | Allele with one delins | Exon 1 | Unknown | CRISPR | |
| hi2092Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| hi2188aTg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| hi2617Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| tl240a | Allele with one point mutation | Unknown | Missense | ENU | |
| tv205c | Allele with one deletion | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cdx4 | (2) | |
| CRISPR2-cdx4 | Saunders et al., 2023 | |
| CRISPR3-cdx4 | Saunders et al., 2023 | |
| CRISPR4-cdx4 | Saunders et al., 2023 | |
| MO1-cdx4 | N/A | (11) |
| MO2-cdx4 | N/A | Hart et al., 2007 |
| MO3-cdx4 | N/A | Hart et al., 2009 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Caudal homeobox | Caudal-like activation domain | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A8KBT9 | InterPro | 270 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(cdx4:EGFP) |
|
| 1 | (4) | |
| Tg(hsp70l:cdx4) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-231B5 | ZFIN Curated Data | |
| Contained in | BAC | CH211-276G21 | ZFIN Curated Data | |
| Encodes | BAC END | zk14a10.t7 | ||
| Encodes | EST | cb546 | Thisse et al., 2001 | |
| Encodes | EST | ibd1215 | ZFIN Curated Data | |
| Encodes | EST | ibd2812 | ||
| Encodes | EST | ibd5107 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:91785 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174156 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174157 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131109 (1) | 1653 nt | ||
| Genomic | GenBank:AL935131 (1) | 170938 nt | ||
| Polypeptide | UniProtKB:A8KBT9 (1) | 270 aa |
- Matsumoto, K., Akieda, Y., Haraoka, Y., Hirono, N., Sasaki, H., Ishitani, T. (2024) Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development. Nature communications. 15:1066210662
- Saunders, L.M., Srivatsan, S.R., Duran, M., Dorrity, M.W., Ewing, B., Linbo, T.H., Shendure, J., Raible, D.W., Moens, C.B., Kimelman, D., Trapnell, C. (2023) Embryo-scale reverse genetics at single-cell resolution. Nature. 623(7988):782-791
- Prummel, K.D., Crowell, H.L., Nieuwenhuize, S., Brombacher, E.C., Daetwyler, S., Soneson, C., Kresoja-Rakic, J., Kocere, A., Ronner, M., Ernst, A., Labbaf, Z., Clouthier, D.E., Firulli, A.B., Sánchez-Iranzo, H., Naganathan, S.R., O'Rourke, R., Raz, E., Mercader, N., Burger, A., Felley-Bosco, E., Huisken, J., Robinson, M.D., Mosimann, C. (2022) Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma. Nature communications. 13:1677
- Rocha, M., Kushkowski, E., Schnirman, R., Booth, C., Singh, N., Beadell, A., Prince, V.E. (2021) Zebrafish Cdx4 regulates neural crest cell specification and migratory behaviors in the posterior body. Developmental Biology. 480:25-38
- Wang, B., Rong, X., Zhou, Y., Liu, Y., Sun, J., Zhao, B., Deng, B., Lu, L., Lu, L., Li, Y., Zhou, J. (2021) Eukaryotic initiation factor 4A3 inhibits Wnt/β-catenin signaling and regulates axis formation in zebrafish embryos. Development (Cambridge, England). 148(9):
- Chestnut, B., Casie Chetty, S., Koenig, A.L., Sumanas, S. (2020) Single-cell transcriptomic analysis identifies the conversion of zebrafish Etv2-deficient vascular progenitors into skeletal muscle. Nature communications. 11:2796
- Lavergne, A., Tarifeño-Saldivia, E., Pirson, J., Reuter, A.S., Flasse, L., Manfroid, I., Voz, M.L., Peers, B. (2020) Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmes. BMC Biology. 18:109
- Quintanilla, C.A., Ho, R.K. (2020) The Cdx transcription factors and retinoic acid play parallel roles in antero-posterior position of the pectoral fin field during gastrulation. Mechanisms of Development. 164:103644
- Rogers, K.W., ElGamacy, M., Jordan, B.M., Müller, P. (2020) Optogenetic investigation of BMP target gene expression diversity. eLIFE. 9:
- Ye, Z., Kimelman, D. (2020) hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development. Development (Cambridge, England). 147(22):
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