Gene
ela3l
- ID
- ZDB-GENE-060710-2
- Name
- elastase 3 like
- Symbol
- ela3l Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in digestive system; exocrine pancreas; and pancreas. Orthologous to human CELA3A (chymotrypsin like elastase 3A) and CELA3B (chymotrypsin like elastase 3B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109943 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la024923Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa18102 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa20417 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa26473 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
Domain | IPR001254 | Serine proteases, trypsin domain |
Family | IPR001314 | Peptidase S1A, chymotrypsin family |
Family | IPR050850 | Peptidase S1 family, Elastase subfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Peptidase S1A, chymotrypsin family | Peptidase S1 family, Elastase subfamily | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site | Serine proteases, trypsin family, serine active site |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q504D4 | InterPro | 201 | |||||||
UniProtKB:A0A8M9QDY3 | InterPro | 270 | |||||||
UniProtKB:A2BGP5 | InterPro | 269 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg1(ela3l:Cre,cryaa:Venus) |
|
| 1 | Zebrafish Nomenclature Committee | |
Tg(ela3l:casp8,ela3l:Crimson) |
|
| 1 | (3) | |
Tg(ela3l:Cre,cryaa:Venus) |
|
| 1 | (4) | |
Tg(ela3l:Crimson) |
|
| 1 | (2) | |
Tg(ela3l:EGFP) |
|
| 2 | (137) | |
Tg(ela3l:H2B-EGFP) |
|
| 1 | (2) | |
Tg(ela3l:Hsa.HBEGF_I117V_L148V,ela3l:Crimson) |
|
| 1 | Schmitner et al., 2017 | |
Tg(ela3l:mCherry,myl7:EGFP) |
|
| 1 | Freudenblum et al., 2018 | |
Tg(ela3l:TagRFP-NTR) |
|
| 1 | (2) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-214J8 | ZFIN Curated Data | |
Encodes | EST | fd58f03 | ||
Encodes | cDNA | MGC:109943 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192180 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001024408 (1) | 921 nt | ||
Genomic | GenBank:BX510923 (1) | 165838 nt | ||
Polypeptide | UniProtKB:A0A8M9QDY3 (1) | 270 aa |
No data available
- Bordeira-Carriço, R., Teixeira, J., Duque, M., Galhardo, M., Ribeiro, D., Acemel, R.D., Firbas, P.N., Tena, J.J., Eufrásio, A., Marques, J., Ferreira, F.J., Freitas, T., Carneiro, F., Goméz-Skarmeta, J.L., Bessa, J. (2022) Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers. Nature communications. 13:1945
- Ma, J., Shao, X., Geng, F., Liang, S., Yu, C., Zhang, R. (2022) Ercc2/Xpd deficiency results in failure of digestive organ growth in zebrafish with elevated nucleolar stress. iScience. 25:104957
- Yoon, B., Yeung, P., Santistevan, N., Bluhm, L., Kawasaki, K., Kueper, J., Dubielzig, R., Vanoudenhove, J., Cotney, J., Liao, E.C., Grinblat, Y. (2022) Zebrafish models of Alx-linked frontonasal dysplasia reveal a role for Alx1 and Alx3 in the anterior segment and vasculature of the developing eye. Biology Open. 11(5):
- Korzh, S., Winata, C.L., Gong, Z., Korzh, V. (2021) The development of zebrafish pancreas affected by deficiency of Hedgehog signaling. Gene expression patterns : GEP. 41:119185
- Lee, H.C., Fu, C.Y., Lin, C.Y., Hu, J.R., Huang, T.Y., Lo, K.Y., Tsai, H.Y., Sheu, J.C., Tsai, H.J. (2021) Poly(U)-specific endoribonuclease ENDOU promotes translation of human CHOP mRNA by releasing uORF element-mediated inhibition. The EMBO journal. 40(11):e104123
- Peña, O.A., Lubin, A., Hockings, C., Rowell, J., Jung, Y., Hoade, Y., Dace, P.E.I., Valdivia, L.E., Tuschl, K., Boiers, C., Virgilio, M., Richardson, S.E., Payne, E.M. (2021) TLR7 ligation augments hematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signalling. Blood advances. 5(20):4112-4124
- Jiang, J., Chen, L., Wu, S., Lv, L., Liu, X., Wang, Q., Zhao, X. (2020) Effects of difenoconazole on hepatotoxicity, lipid metabolism and gut microbiota in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 265:114844
- Freudenblum, J., Iglesias, J.A., Hermann, M., Walsen, T., Wilfinger, A., Meyer, D., Kimmel, R.A. (2018) In vivo imaging of emerging endocrine cells reveals a requirement for PI3K-regulated motility in pancreatic islet morphogenesis.. Development (Cambridge, England). 145(3)
- DeBofsky, A.R., Klingler, R.H., Mora-Zamorano, F.X., Walz, M., Shepherd, B., Larson, J.K., Anderson, D., Yang, L., Goetz, F., Basu, N., Head, J., Tonellato, P., Armstrong, B.M., Murphy, C., Carvan, M.J. (2017) Female reproductive impacts of dietary methylmercury in yellow perch (Perca flavescens) and zebrafish (Danio rerio). Chemosphere. 195:301-311
- Schmitner, N., Kohno, K., Meyer, D. (2017) ptf1a+ , ela3l- cells are developmentally maintained progenitors for exocrine regeneration following extreme loss of acinar cells in zebrafish larvae.. Disease models & mechanisms. 10(3):307-321
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