Gene
casp8
- ID
- ZDB-GENE-000713-1
- Name
- caspase 8, apoptosis-related cysteine peptidase
- Symbol
- casp8 Nomenclature History
- Previous Names
-
- caspase-8a (1)
- zgc:92075
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type endopeptidase activity. Acts upstream of or within positive regulation of apoptotic process and symbiont-mediated activation of host apoptosis. Predicted to be located in nucleus and plasma membrane. Predicted to be part of CD95 death-inducing signaling complex. Predicted to be active in cytoplasm. Is expressed in several structures, including axis; germ ring; intestine; male organism; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune lymphoproliferative syndrome type 2B; breast cancer; endocrine gland cancer (multiple); esophagus adenocarcinoma; and lung cancer. Orthologous to human CASP8 (caspase 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 50 figures from 45 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autoimmune lymphoproliferative syndrome type 2B | Alliance | ?Caspase 8 lymphadenopathy syndrome | 607271 |
| breast cancer | Alliance | {Breast cancer, protection against} | 114480 |
| hepatocellular carcinoma | Alliance | Hepatocellular carcinoma, somatic | 114550 |
| lung cancer | Alliance | {Lung cancer, protection against} | 211980 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR033139 | Peptidase family C14A, cysteine active site |
| Domain | IPR001309 | Peptidase C14, p20 domain |
| Domain | IPR001875 | Death effector domain |
| Domain | IPR002138 | Peptidase C14, caspase non-catalytic subunit p10 |
| Domain | IPR011600 | Peptidase C14, caspase domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Caspase-like domain superfamily | Death effector domain | Death-like domain superfamily | Peptidase C14A, caspase catalytic domain | Peptidase C14, caspase domain | Peptidase C14, caspase non-catalytic subunit p10 | Peptidase C14, p20 domain | Peptidase family C14A, cysteine active site |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BD46 | InterPro | 477 | ||||||||
| UniProtKB:Q66I19 | InterPro | 476 | ||||||||
| UniProtKB:A0AB32TR51 | InterPro | 472 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(ca8:FMA-TagRFP-2A-casp8-ERT2) |
| 1 | (2) | ||
| Tg(ela3l:casp8,ela3l:Crimson) |
|
| 1 | (3) | |
| Tg(HSE:mCherry-Ath.Cry2_E490G-casp8,myl7:TagRFP) |
| 1 | (2) | ||
| Tg(ins:casp8,ins:Crimson) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-71C20 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92075 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131510 (1) | 2056 nt | ||
| Genomic | GenBank:CU639421 (2) | 105459 nt | ||
| Polypeptide | UniProtKB:A0A8M2BD46 (1) | 477 aa |
- Xia, X., Song, W., Zhang, F., Fan, Y., Zhang, B., Chen, X. (2025) ctdsp2 Knockout Induces Zebrafish Craniofacial Dysplasia via p53 Signaling Activation. International Journal of Molecular Sciences. 26:
- Zhou, X., Cao, J., Xie, J., Tong, W., Jia, B., Fu, J. (2025) Effect of Dync1h1 on Phototransduction Protein Transport and the Development and Maintenance of Photoreceptor Cells in Zebrafish. Investigative ophthalmology & visual science. 66:3838
- Jing, Y., Luo, Y., Li, L., Liu, M., Liu, J.X. (2024) Deficiency of copper responsive gene stmn4 induces retinal developmental defects. Cell biology and toxicology. 40:22
- Méjécase, C., Nair, N., Sarkar, H., Soro-Barrio, P., Toms, M., Halliday, S., Linkens, K., Jaroszynska, N., Maurer, C., Owen, N., Moosajee, M. (2024) Oxidative Stress, Inflammation and Altered Glucose Metabolism Contribute to the Retinal Phenotype in the Choroideremia Zebrafish. Antioxidants (Basel, Switzerland). 13(12):
- Ren, M., Chen, X., Dai, L., Tu, J., Hu, H., Sun, X., Luo, J., Li, P., Fu, Y., Zhu, Y., Sun, W., Tang, Z., Liu, M., Ren, X., Lu, Q. (2024) Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish. Biomedicines. 13:
- Wang, Z., Wang, C., Zhai, Y., Bai, Y., Wang, H., Rong, X. (2024) Loss of Brcc3 in Zebrafish Embryos Increases Their Susceptibility to DNA Damage Stress. International Journal of Molecular Sciences. 25(22):
- Accogli, A., Lin, S.J., Severino, M., Kim, S.H., Huang, K., Rocca, C., Landsverk, M., Zaki, M., Al-Maawali, A., Srinivasan, V.M., Al-Thihli, K., Schaefer, G.B., Davis, M., Tonduti, D., Doneda, C., Marten, L.M., Mühlhausen, C., Gomez, M., Lamantea, E., Mena, R., Nizon, M., Procaccio, V., Begtrup, A., Telegrafi, A., Cui, H., Schulz, H.L., Mohr, J., Biskup, S., Loos, M.A., Aráoz, H.V., Salpietro, V., Keppen, L.D., Chitre, M., Petree, C., Raymond, L., Vogt, J., Swayer, L.B., Basinger, A.A., Pedersen, S.V., Pearson, T.S., Grange, D.K., Lingapp, L., McDunnah, P., Horvath, R., Cogne, B., Isidor, B., Hahn, A., Gripp, K., Jafarnejad, S.M., Ostergaard, E., Prada, C.E., Ghezzi, D., Gowda, V.K., Taylor, R.W., Sonenberg, N., Houlden, H., Sissler, M., Varshney, G.K., Maroofian, R. (2023) Clinical, neuroradiological and molecular characterization of mitochondrial threonyl-tRNA-synthetase (TARS2)-related disorder. Genetics in medicine : official journal of the American College of Medical Genetics. 25(11):100938
- Azbazdar, Y., Poyraz, Y.K., Ozalp, O., Nazli, D., Ipekgil, D., Cucun, G., Ozhan, G. (2023) High-fat diet feeding triggers a regenerative response in the adult zebrafish brain. Molecular neurobiology. 60(5):2486-2506
- Da'as, S.I., Ahmed, I., Hasan, W.H., Abdelrahman, D.A., Aliyev, E., Nisar, S., Bhat, A.A., Joglekar, M.V., Hardikar, A.A., Fakhro, K.A., Akil, A.S.A. (2023) The link between glycemic control measures and eye microvascular complications in a clinical cohort of type 2 diabetes with microRNA-223-3p signature. Journal of translational medicine. 21:171171
- Karagöz, A., Beler, M., Altun, B.D., Ünal, İ., Cansız, D., Gündüz, H., Alturfan, A.A., Emekli-Alturfan, E., Erçalık-Yalçınkaya, Ş. (2023) Panoramic Dental X-ray Exposure Leads to Oxidative stress, Inflammation and Apoptosis-mediated Developmental Defects in Zebrafish Embryos. Journal of stomatology, oral and maxillofacial surgery. 124(6S):101661
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