Gene
fgfr1a
- ID
- ZDB-GENE-980526-255
- Name
- fibroblast growth factor receptor 1a
- Symbol
- fgfr1a Nomenclature History
- Previous Names
-
- fgfr1
- cb231 (1)
- sb:cb231
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables fibroblast growth factor receptor activity. Acts upstream of or within several processes, including fin regeneration; negative regulation of endodermal cell fate specification; and nervous system development. Predicted to be located in cytosol and nucleus. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including embryonic structure; head; intestine; nervous system; and trunk vasculature. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; bone disease (multiple); carcinoma (multiple); hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to human FGFR1 (fibroblast growth factor receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 79 figures from 55 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb231 (14 images)
- eu444 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu3264 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| la026639Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la029507Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa1689 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa6106 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12393 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
| sa16812 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21393 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21394 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21395 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fgfr1a | Leerberg et al., 2019 | |
| CRISPR2-fgfr1a | Chen et al., 2020 | |
| CRISPR3-fgfr1a | Chen et al., 2020 | |
| CRISPR4-fgfr1a | Lin et al., 2025 | |
| CRISPR5-fgfr1a | Lin et al., 2025 | |
| CRISPR6-fgfr1a | Lin et al., 2025 | |
| MO1-fgfr1a | N/A | (17) |
| MO2-fgfr1a | N/A | (4) |
| MO3-fgfr1a | N/A | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 2 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 2 with or without anosmia | 147950 |
| Jackson-Weiss syndrome | Alliance | Jackson-Weiss syndrome | 123150 |
| osteoglophonic dysplasia | Alliance | Osteoglophonic dysplasia | 166250 |
| Pfeiffer syndrome | Alliance | Pfeiffer syndrome | 101600 |
| Encephalocraniocutaneous lipomatosis, somatic mosaic | 613001 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fibroblast growth factor receptor 1, catalytic domain | Fibroblast growth factor receptor family | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A891XJQ6 | InterPro | ||||||||||||||||
| UniProtKB:A0A891XJP9 | InterPro | ||||||||||||||||
| UniProtKB:A0A891XJS9 | InterPro | ||||||||||||||||
| UniProtKB:Q90Z00 | InterPro | 810 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
fgfr1a-202
(1)
|
Ensembl | 2,381 nt | ||
| mRNA |
fgfr1a-201
(1)
|
Ensembl | 2,430 nt | ||
| mRNA |
fgfr1a-203
(1)
|
Ensembl | 2,190 nt | ||
| mRNA |
fgfr1a-204
(1)
|
Ensembl | 7,050 nt | ||
| mRNA |
fgfr1a-206
(1)
|
Ensembl | 2,808 nt |
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Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| AB1-fgfr1a | monoclonal | Mouse |
|
1 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:dnfgfr1a-EGFP) |
|
| 1 | (114) | |
| Tg(-1.5hsp70l:LOXP-STOP-LOXP-dnfgfr1a-Cerulean-CAAX,cryaa:YFP) |
| 1 | Kirchgeorg et al., 2018 | ||
| Tg(en.len-lepb:dnfgfr1a-EGFP,eef1a1l1:NLS-mCherry) |
| 1 | Kang et al., 2016 | ||
| Tg(fabp10a:dnfgfr1-EGFP) |
|
| 1 | (3) | |
| Tg(hsp70l:LOXP-3xSTOP-LOXP-dnfgfr1a-EGFP,cryaa:DsRed) |
| 1 | Zhao et al., 2021 | ||
| Tg(lepb:dnfgfr1a-EGFP,eef1a1l1:NLS-mCherry) |
| 2 | Kang et al., 2016 | ||
| Tg(UAS:dnfgfr1a,myl7:EGFP) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-198O12 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-111H22 | ZFIN Curated Data | |
| Encodes | EST | cb231 | Thisse et al., 2001 | |
| Encodes | EST | eu444 | Thisse et al., 2005 | |
| Encodes | cDNA | cssl:d107 | Bushell et al., 2007 | |
| Encodes | cDNA | MGC:193969 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_152962 (1) | 3150 nt | ||
| Genomic | GenBank:CR376860 (2) | 195545 nt | ||
| Polypeptide | UniProtKB:Q90Z00 (1) | 810 aa |
- Ali, M., Kutlowski, J.W., Holland, J.N., Riley, B.B. (2025) Foxm1 promotes differentiation of neural progenitors in the zebrafish inner ear. Developmental Biology. 520:213021-30
- Lin, S.J., Huang, K., Petree, C., Qin, W., Varshney, P., Varshney, G.K. (2025) Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function. Nucleic acids research. 53:
- Chen, F., Pu, S., Tian, L., Zhang, H., Zhou, H., Yan, Y., Hu, X., Wu, Q., Chen, X., Cheng, S.H., Xu, S. (2024) Radix Rehmanniae Praeparata promoted zebrafish fin regeneration through aryl hydrocarbon receptor-dependent autophagy. Journal of ethnopharmacology. 331:118272
- Jin, S., Choe, C.P. (2024) A Potential Role of fgf4, fgf24, and fgf17 in Pharyngeal Pouch Formation in Zebrafish. Development & reproduction. 28:556555-65
- Tuttle, A.M., Miller, L.N., Royer, L.J., Wen, H., Kelly, J.J., Calistri, N.L., Heiser, L.M., Nechiporuk, A.V. (2024) Single-cell analysis of Rohon-Beard neurons implicates Fgf signaling in axon maintenance and cell survival. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(16):
- Cudak, N., López-Delgado, A.C., Keil, S., Knopf, F. (2023) Fibroblast growth factor pathway component expression in the regenerating zebrafish fin. Gene expression patterns : GEP. 48:119307
- Drepanos, L., Gans, I.M., Grendler, J., Guitar, S., Fuqua, J.H., Maki, N.J., Tilden, A.R., Graber, J.H., Coffman, J.A. (2023) Loss of Krüppel-like factor 9 deregulates both physiological gene expression and development. Scientific Reports. 13:1223912239
- Niu, X., Zhang, F., Ping, L., Wang, Y., Zhang, B., Wang, J., Chen, X. (2023) vwa1 Knockout in Zebrafish Causes Abnormal Craniofacial Chondrogenesis by Regulating FGF Pathway. Genes. 14(4):
- Shi, T., Beaulieu, M.O., Saunders, L.M., Fabian, P., Trapnell, C., Segil, N., Crump, J.G., Raible, D.W. (2023) Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes. eLIFE. 12:
- Zhou, C., Chen, J., Liu, K., Maharajan, K., Zhang, Y., Hou, L., Li, J., Mi, M., Xia, Q. (2023) Isoalantolactone protects against ethanol-induced gastric ulcer via alleviating inflammation through regulation of PI3K-Akt signaling pathway and Th17 cell differentiation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 160:114315114315
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