Gene
fgfr1a
- ID
- ZDB-GENE-980526-255
- Name
- fibroblast growth factor receptor 1a
- Symbol
- fgfr1a Nomenclature History
- Previous Names
-
- fgfr1
- cb231 (1)
- sb:cb231
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables fibroblast growth factor receptor activity. Acts upstream of or within several processes, including fin regeneration; negative regulation of endodermal cell fate specification; and nervous system development. Predicted to be located in several cellular components, including cytoplasmic vesicle; cytosol; and nucleus. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including embryonic structure; head; intestine; nervous system; and trunk vasculature. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; bone disease (multiple); carcinoma (multiple); hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to human FGFR1 (fibroblast growth factor receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 79 figures from 55 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb231 (14 images)
- eu444 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
hu3264 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
la026639Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la029507Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa1689 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa6106 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa12393 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
sa16812 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa21393 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa21394 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa21395 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-fgfr1a | Leerberg et al., 2019 | |
CRISPR2-fgfr1a | Chen et al., 2020 | |
CRISPR3-fgfr1a | Chen et al., 2020 | |
CRISPR4-fgfr1a | Lin et al., 2025 | |
CRISPR5-fgfr1a | Lin et al., 2025 | |
CRISPR6-fgfr1a | Lin et al., 2025 | |
MO1-fgfr1a | N/A | (17) |
MO2-fgfr1a | N/A | (4) |
MO3-fgfr1a | N/A | (3) |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
hypogonadotropic hypogonadism 2 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 2 with or without anosmia | 147950 |
Jackson-Weiss syndrome | Alliance | Jackson-Weiss syndrome | 123150 |
osteoglophonic dysplasia | Alliance | Osteoglophonic dysplasia | 166250 |
Pfeiffer syndrome | Alliance | Pfeiffer syndrome | 101600 |
Encephalocraniocutaneous lipomatosis, somatic mosaic | 613001 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008266 | Tyrosine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
Domain | IPR003598 | Immunoglobulin subtype 2 |
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Domain Details Per Protein
Protein | Additional Resources | Length | Fibroblast growth factor receptor 1, catalytic domain | Fibroblast growth factor receptor family | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A891XJQ6 | InterPro | ||||||||||||||||
UniProtKB:A0A891XJP9 | InterPro | ||||||||||||||||
UniProtKB:A0A891XJS9 | InterPro | ||||||||||||||||
UniProtKB:Q90Z00 | InterPro | 810 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
aberrant processed transcript |
fgfr1a-202
(1)
|
Ensembl | 2,381 nt | ||
mRNA |
fgfr1a-201
(1)
|
Ensembl | 2,430 nt | ||
mRNA |
fgfr1a-203
(1)
|
Ensembl | 2,190 nt | ||
mRNA |
fgfr1a-204
(1)
|
Ensembl | 7,050 nt | ||
mRNA |
fgfr1a-206
(1)
|
Ensembl | 2,808 nt |
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Interactions and Pathways
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
AB1-fgfr1a | monoclonal | Mouse |
|
1 |
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Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(hsp70l:dnfgfr1a-EGFP) |
|
| 1 | (114) | |
Tg(-1.5hsp70l:LOXP-STOP-LOXP-dnfgfr1a-Cerulean-CAAX,cryaa:YFP) |
| 1 | Kirchgeorg et al., 2018 | ||
Tg(en.len-lepb:dnfgfr1a-EGFP,eef1a1l1:NLS-mCherry) |
| 1 | Kang et al., 2016 | ||
Tg(fabp10a:dnfgfr1-EGFP) |
|
| 1 | (3) | |
Tg(hsp70l:LOXP-3xSTOP-LOXP-dnfgfr1a-EGFP,cryaa:DsRed) |
| 1 | Zhao et al., 2021 | ||
Tg(lepb:dnfgfr1a-EGFP,eef1a1l1:NLS-mCherry) |
| 2 | Kang et al., 2016 | ||
Tg(UAS:dnfgfr1a,myl7:EGFP) |
|
| 1 | (4) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-198O12 | ZFIN Curated Data | |
Contained in | BAC | DKEY-111H22 | ZFIN Curated Data | |
Encodes | EST | cb231 | Thisse et al., 2001 | |
Encodes | EST | eu444 | Thisse et al., 2005 | |
Encodes | cDNA | cssl:d107 | Bushell et al., 2007 | |
Encodes | cDNA | MGC:193969 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_152962 (1) | 3150 nt | ||
Genomic | GenBank:CR376860 (2) | 195545 nt | ||
Polypeptide | UniProtKB:Q90Z00 (1) | 810 aa |
- Ali, M., Kutlowski, J.W., Holland, J.N., Riley, B.B. (2025) Foxm1 promotes differentiation of neural progenitors in the zebrafish inner ear. Developmental Biology. 520:213021-30
- Lin, S.J., Huang, K., Petree, C., Qin, W., Varshney, P., Varshney, G.K. (2025) Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function. Nucleic acids research. 53:
- Chen, F., Pu, S., Tian, L., Zhang, H., Zhou, H., Yan, Y., Hu, X., Wu, Q., Chen, X., Cheng, S.H., Xu, S. (2024) Radix Rehmanniae Praeparata promoted zebrafish fin regeneration through aryl hydrocarbon receptor-dependent autophagy. Journal of ethnopharmacology. 331:118272
- Jin, S., Choe, C.P. (2024) A Potential Role of fgf4, fgf24, and fgf17 in Pharyngeal Pouch Formation in Zebrafish. Development & reproduction. 28:556555-65
- Tuttle, A.M., Miller, L.N., Royer, L.J., Wen, H., Kelly, J.J., Calistri, N.L., Heiser, L.M., Nechiporuk, A.V. (2024) Single-cell analysis of Rohon-Beard neurons implicates Fgf signaling in axon maintenance and cell survival. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(16):
- Cudak, N., López-Delgado, A.C., Keil, S., Knopf, F. (2023) Fibroblast growth factor pathway component expression in the regenerating zebrafish fin. Gene expression patterns : GEP. 48:119307
- Drepanos, L., Gans, I.M., Grendler, J., Guitar, S., Fuqua, J.H., Maki, N.J., Tilden, A.R., Graber, J.H., Coffman, J.A. (2023) Loss of Krüppel-like factor 9 deregulates both physiological gene expression and development. Scientific Reports. 13:1223912239
- Niu, X., Zhang, F., Ping, L., Wang, Y., Zhang, B., Wang, J., Chen, X. (2023) vwa1 Knockout in Zebrafish Causes Abnormal Craniofacial Chondrogenesis by Regulating FGF Pathway. Genes. 14(4):
- Shi, T., Beaulieu, M.O., Saunders, L.M., Fabian, P., Trapnell, C., Segil, N., Crump, J.G., Raible, D.W. (2023) Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes. eLIFE. 12:
- Zhou, C., Chen, J., Liu, K., Maharajan, K., Zhang, Y., Hou, L., Li, J., Mi, M., Xia, Q. (2023) Isoalantolactone protects against ethanol-induced gastric ulcer via alleviating inflammation through regulation of PI3K-Akt signaling pathway and Th17 cell differentiation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 160:114315114315
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